A cyano analogue of boswellic acid induces crosstalk between p53/PUMA/Bax and telomerase that stages the human papillomavirus type 18 positive HeLa cells to apoptotic death

The p53 tumor suppressor pathway is disrupted by human papillomavirus (HPV) in over 90% of cervical cancers. HPV E6 protein promotes the degradation of p53 thereby inhibiting its stabilization and activation. This study demonstrates that treatment with a novel cyano derivative of 11-keto-β-boswellic...

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Veröffentlicht in:	European journal of pharmacology 2011-06, Vol.660 (2-3), p.241-248
Hauptverfasser:	Khan, Sheema, Chib, Renu, Shah, Bhahwal A., Wani, Z.A., Dhar, Niha, Mondhe, Dilip M., Lattoo, Surrinder, Jain, S.K., Taneja, Subhash C., Singh, Jaswant
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Apoptosis Apoptosis - drug effects Apoptosis Regulatory Proteins - metabolism bcl-2-Associated X Protein - metabolism Biological and medical sciences Carcinoma, Ehrlich Tumor - drug therapy Caspases - metabolism Cell Proliferation - drug effects Cell Survival - drug effects Cytotoxicity DNA Fragmentation - drug effects DNA-Binding Proteins - genetics Enzyme Activation - drug effects Gene Expression Regulation - drug effects Gene Expression Regulation, Neoplastic - drug effects HeLa Cells Human papilloma virus Human papillomavirus Human papillomavirus 18 Human papillomavirus 18 - physiology Humans Medical sciences Membrane Potential, Mitochondrial - drug effects Mice Mitochondria - drug effects Mitochondria - metabolism Nitriles - chemistry Nitriles - pharmacology Nitriles - therapeutic use Oncogene Proteins, Viral - genetics p53 Pharmacology. Drug treatments Polycyclic Compounds - chemistry Polycyclic Compounds - pharmacology Polycyclic Compounds - therapeutic use Proto-Oncogene Proteins - metabolism Resting Phase, Cell Cycle - drug effects RNA, Messenger - genetics RNA, Messenger - metabolism Signal Transduction - drug effects Telomerase Telomerase - metabolism Triterpenes - chemistry Triterpenes - pharmacology Triterpenes - therapeutic use Tumor Suppressor Protein p53 - metabolism
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