Trilysinoyl oleylamide-based cationic liposomes for systemic co-delivery of siRNA and an anticancer drug

Oligolysine-based cationic lipid derivatives were synthesized for delivery of siRNA, and formulated into cationic liposomes. Among various oligolysine-based lipid derivatives differing in lysine residue number and lipid moiety, trilysinoyl oleylamide (TLO)-based liposomes (TLOL) showed the highest d...

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Veröffentlicht in:	Journal of controlled release 2011-10, Vol.155 (1), p.60-66
Hauptverfasser:	Shim, Gayong, Han, Su-Eun, Yu, Yong-Hee, Lee, Sangbin, Lee, Han Young, Kim, Kwangmeyung, Kwon, Ick Chan, Park, Tae Gwan, Kim, Young Bong, Choi, Yong Seok, Kim, Chan-Wha, Oh, Yu-Kyoung
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals anticarcinogenic activity antineoplastic agents Antineoplastic Agents - administration & dosage Antineoplastic Agents - therapeutic use Antitumor activity Cationic liposome Cations - chemistry Cell Line Co-delivery cytotoxicity Female fluorescence Gene Silencing genes green fluorescent protein Humans Hydroxamic Acids - administration & dosage Hydroxamic Acids - therapeutic use intravenous injection Liposomes - chemistry lysine Mice Mice, Nude Myeloid Cell Leukemia Sequence 1 Protein Neoplasms - drug therapy Neoplasms - genetics Neoplasms - pathology Oleic Acids - chemistry Proto-Oncogene Proteins c-bcl-2 - genetics RNA, Small Interfering - administration & dosage RNA, Small Interfering - genetics RNA, Small Interfering - therapeutic use siRNA small interfering RNA Suberoylanilide hydroxamic acid Trilysinoyl oleylamide
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