Instantaneous room-temperature and highly enantioselective ArTi(O-i-Pr)3 additions to aldehydes

Instantaneous room-temperature and highly enantioselective ArTi(O-i-Pr)3 additions to aldehydes

Direct asymmetric additions of ArTi(O-i-Pr)(3) to aldehydes catalyzed by a titanium catalyst of (R)-H(8)-BINOL are reported. The reactions proceed instantaneously at room temperature, affording alcohols in ≥90% ee. Importantly, the ArTi(O-i-Pr)(3) reagent differentiates the ligand effectiveness in a...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Chemical communications (Cambridge, England) England), 2011-11, Vol.47 (42), p.11668-11670
Hauptverfasser: Wu, Kuo-Hui, Zhou, Shuangliu, Chen, Chien-An, Yang, Mao-Chi, Chiang, Ruei-Tang, Chen, Chi-Ren, Gau, Han-Mou
Format: Artikel
Sprache:eng
Schlagworte:
Alcohols
Aldehydes
Aldehydes - chemistry
Argon - chemistry
Asymmetry
Catalysts
Diols
Ligands
Stereoisomerism
Temperature
Titanium
Titanium - chemistry
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Direct asymmetric additions of ArTi(O-i-Pr)(3) to aldehydes catalyzed by a titanium catalyst of (R)-H(8)-BINOL are reported. The reactions proceed instantaneously at room temperature, affording alcohols in ≥90% ee. Importantly, the ArTi(O-i-Pr)(3) reagent differentiates the ligand effectiveness in an order of H(8)-BINOL > BINOL > TADDOL > diol 3 > disulfonamide 2.
ISSN:1359-7345
1364-548X
DOI:10.1039/c1cc15059f