The role of CD4-dependent signaling in interleukin-16 induced c-Fos expression and facilitation of neurite outgrowth in cerebellar granule neurons

▶ CD4 is expressed in cerebellar granule neurons (CGCs) as evidenced using RT-PCR and immunoblotting. ▶ IL-16 induces c-Fos expression in wild-type CGCs, but not in CD4-deficient CGCs. ▶ IL-16 enhances neurite outgrowth for wild-type as well as CD4-deficient CGCs. Neuronal interleukin 16 (NIL-16) is...

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Veröffentlicht in:	Neuroscience letters 2010-11, Vol.485 (3), p.212-216
Hauptverfasser:	Fenster, Catherine P., Chisnell, Hope K., Fry, Carl R., Fenster, Steven D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences CD4 CD4 Antigens - genetics CD4 Antigens - physiology CD4-Positive T-Lymphocytes - physiology Cell Survival - drug effects Cerebellar granule neurons Cerebellum - cytology Cerebellum - drug effects Fundamental and applied biological sciences. Psychology Gene Expression - drug effects Gene Expression - genetics Genes, fos - genetics Interleukin-16 Interleukin-16 - pharmacology Lymphocyte Specific Protein Tyrosine Kinase p56(lck) - antagonists & inhibitors Lymphocyte Specific Protein Tyrosine Kinase p56(lck) - physiology Mice Mice, Inbred C57BL Mice, Knockout Neurite outgrowth Neurites - drug effects Neurites - physiology Neuronal interleukin-16 Neurons - drug effects Neurons - physiology RNA - biosynthesis RNA - genetics Signal Transduction - drug effects Vertebrates: nervous system and sense organs
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