Dynamic and specific interaction between synaptic NR2-NMDA receptor and PDZ proteins

The relative content of NR2 subunits in the NMDA receptor confers specific signaling properties and plasticity to synapses. However, the mechanisms that dynamically govern the retention of synaptic NMDARs, in particular 2A-NMDARs, remain poorly understood. Here, we investigate the dynamic interactio...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2010-11, Vol.107 (45), p.19561-19566
Hauptverfasser:	Bard, Lucie, Sainlos, Matthieu, Bouchet, Delphine, Cousins, Sarah, Mikasova, Lenka, Breillat, Christelle, Stephenson, F. Anne, Imperiali, Barbara, Choquet, Daniel, Groc, Laurent, Huganir, Richard L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Animals Biological Sciences Chemical bonds Data processing Drug interactions Glutamic acid receptors Glutamic acid receptors (ionotropic) Homology imaging Kinetics Ligands Mimicry Molecules N methyl D aspartate receptors N-Methyl-D-aspartic acid receptors Neuronal Plasticity Neurons Neuroscience Oligopeptides - pharmacology PDZ Domains Peptide Fragments - pharmacology Physiological regulation Postsynaptic density proteins Protein Binding Protein Subunits - metabolism Proteins Rats Rats, Sprague-Dawley Receptor mechanisms Receptors Receptors, N-Methyl-D-Aspartate - metabolism scaffolds Scientific imaging Signal transduction Synapses Synapses - chemistry Synaptic Transmission Trajectories Zonula occludens-1 protein
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