Cognitive functioning in chronic fatigue syndrome: a meta-analysis
Cognitive problems are commonly reported in persons with chronic fatigue syndrome (CFS) and are one of the most disabling symptoms of this condition. A number of cognitive deficits have been identified, although the findings are inconsistent and hindered by methodological differences. The current st...
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| Veröffentlicht in: | Psychological medicine 2010-08, Vol.40 (8), p.1253-1267 |
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| description | Cognitive problems are commonly reported in persons with chronic fatigue syndrome (CFS) and are one of the most disabling symptoms of this condition. A number of cognitive deficits have been identified, although the findings are inconsistent and hindered by methodological differences. The current study therefore conducted a meta-analysis of research examining cognitive functioning in persons with CFS in order to identify the pattern and magnitude of any deficits that are associated with this condition.
A comprehensive search of the PubMed and PsycINFO databases for studies that examined cognitive functioning in CFS between 1988 and 2008 identified 50 eligible studies. Weighted Cohen's d effect sizes, 95% confidence intervals and fail-safe Ns were calculated for each cognitive score.
Evidence of cognitive deficits in persons with CFS was found primarily in the domains of attention, memory and reaction time. Deficits were not apparent on tests of fine motor speed, vocabulary, reasoning and global functioning.
Persons with CFS demonstrate moderate to large impairments in simple and complex information processing speed and in tasks requiring working memory over a sustained period of time. |
| doi_str_mv | 10.1017/S0033291709992054 |
| format | Article |
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A comprehensive search of the PubMed and PsycINFO databases for studies that examined cognitive functioning in CFS between 1988 and 2008 identified 50 eligible studies. Weighted Cohen's d effect sizes, 95% confidence intervals and fail-safe Ns were calculated for each cognitive score.
Evidence of cognitive deficits in persons with CFS was found primarily in the domains of attention, memory and reaction time. Deficits were not apparent on tests of fine motor speed, vocabulary, reasoning and global functioning.
Persons with CFS demonstrate moderate to large impairments in simple and complex information processing speed and in tasks requiring working memory over a sustained period of time.</description><identifier>ISSN: 0033-2917</identifier><identifier>EISSN: 1469-8978</identifier><identifier>DOI: 10.1017/S0033291709992054</identifier><identifier>PMID: 20047703</identifier><identifier>CODEN: PSMDCO</identifier><language>eng</language><publisher>Cambridge, UK: Cambridge University Press</publisher><subject>Adolescent ; Adult ; Adult and adolescent clinical studies ; Aged ; Attention ; Biological and medical sciences ; Chronic fatigue syndrome ; Cognition & reasoning ; Cognition Disorders - diagnosis ; Cognition Disorders - psychology ; cognitive ; Cognitive deficits ; Cognitive functioning ; Comorbidity ; Confidence intervals ; Depressive Disorder - diagnosis ; Depressive Disorder - psychology ; Fatigue Syndrome, Chronic - diagnosis ; Fatigue Syndrome, Chronic - psychology ; Female ; Humans ; Magnitude ; Male ; Medical sciences ; Mental Recall ; Meta-analysis ; Middle Aged ; Miscellaneous ; Neuropsychological Tests ; Psychology. Psychoanalysis. Psychiatry ; Psychomotor Performance ; Psychopathology. Psychiatry ; Reaction Time ; review ; Systematic review ; Vocabulary ; Young Adult</subject><ispartof>Psychological medicine, 2010-08, Vol.40 (8), p.1253-1267</ispartof><rights>Copyright © Cambridge University Press 2010</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c569t-58105e7844e7f9315d4ef2e11065d1ff0ad9123d0a784de79452711bc0a8e9e03</citedby><cites>FETCH-LOGICAL-c569t-58105e7844e7f9315d4ef2e11065d1ff0ad9123d0a784de79452711bc0a8e9e03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.cambridge.org/core/product/identifier/S0033291709992054/type/journal_article$$EHTML$$P50$$Gcambridge$$H</linktohtml><link.rule.ids>164,314,780,784,12846,27924,27925,30999,31000,55628</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23000495$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20047703$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cockshell, S. J.</creatorcontrib><creatorcontrib>Mathias, J. L.</creatorcontrib><title>Cognitive functioning in chronic fatigue syndrome: a meta-analysis</title><title>Psychological medicine</title><addtitle>Psychol. Med</addtitle><description>Cognitive problems are commonly reported in persons with chronic fatigue syndrome (CFS) and are one of the most disabling symptoms of this condition. A number of cognitive deficits have been identified, although the findings are inconsistent and hindered by methodological differences. The current study therefore conducted a meta-analysis of research examining cognitive functioning in persons with CFS in order to identify the pattern and magnitude of any deficits that are associated with this condition.
A comprehensive search of the PubMed and PsycINFO databases for studies that examined cognitive functioning in CFS between 1988 and 2008 identified 50 eligible studies. Weighted Cohen's d effect sizes, 95% confidence intervals and fail-safe Ns were calculated for each cognitive score.
Evidence of cognitive deficits in persons with CFS was found primarily in the domains of attention, memory and reaction time. Deficits were not apparent on tests of fine motor speed, vocabulary, reasoning and global functioning.
Persons with CFS demonstrate moderate to large impairments in simple and complex information processing speed and in tasks requiring working memory over a sustained period of time.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Adult and adolescent clinical studies</subject><subject>Aged</subject><subject>Attention</subject><subject>Biological and medical sciences</subject><subject>Chronic fatigue syndrome</subject><subject>Cognition & reasoning</subject><subject>Cognition Disorders - diagnosis</subject><subject>Cognition Disorders - psychology</subject><subject>cognitive</subject><subject>Cognitive deficits</subject><subject>Cognitive functioning</subject><subject>Comorbidity</subject><subject>Confidence intervals</subject><subject>Depressive Disorder - diagnosis</subject><subject>Depressive Disorder - psychology</subject><subject>Fatigue Syndrome, Chronic - diagnosis</subject><subject>Fatigue Syndrome, Chronic - psychology</subject><subject>Female</subject><subject>Humans</subject><subject>Magnitude</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mental Recall</subject><subject>Meta-analysis</subject><subject>Middle Aged</subject><subject>Miscellaneous</subject><subject>Neuropsychological Tests</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychomotor Performance</subject><subject>Psychopathology. Psychiatry</subject><subject>Reaction Time</subject><subject>review</subject><subject>Systematic review</subject><subject>Vocabulary</subject><subject>Young Adult</subject><issn>0033-2917</issn><issn>1469-8978</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>7QJ</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqN0Utv1DAQAGALgehS-AFcUISEegrM-Blzg1VpEZVQeZwtbzJZXBKn2Ali_z2JdmklEIKTLc034xkPY48RniOgefERQAhu0YC1loOSd9gKpbZlZU11l62WcLnEj9iDnK8AUKDk99kRB5DGgFix1-thG8MYvlPRTrEewxBD3BYhFvWXNN_rovVj2E5U5F1s0tDTy8IXPY2-9NF3uxzyQ3av9V2mR4fzmH1-c_ppfV5evD97u351UdZK27FUFYIiU0lJprUCVSOp5YQIWjXYtuAbi1w04GfTkLFScYO4qcFXZAnEMTvZ171Ow7eJ8uj6kGvqOh9pmLKrrEXBFVf_lEZJlKiq_5BCaD43u7z-9Dd5NUxp_oLslDGaG17pGeEe1WnIOVHrrlPofdo5BLeszP2xsjnnyaHwtOmpucn4taMZPDsAn2vftcnHOuRbJ2CWdpml3LuQR_pxE_fpq9NGGOX02aUT7z5IofWlO5-9ODTr-00KzZZuR_p7uz8BnSy5Jw</recordid><startdate>20100801</startdate><enddate>20100801</enddate><creator>Cockshell, S. 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L.</creator><general>Cambridge University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0-V</scope><scope>3V.</scope><scope>7QJ</scope><scope>7QP</scope><scope>7QR</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ALSLI</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HEHIP</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2S</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20100801</creationdate><title>Cognitive functioning in chronic fatigue syndrome: a meta-analysis</title><author>Cockshell, S. 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Psychoanalysis. Psychiatry</topic><topic>Psychomotor Performance</topic><topic>Psychopathology. Psychiatry</topic><topic>Reaction Time</topic><topic>review</topic><topic>Systematic review</topic><topic>Vocabulary</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cockshell, S. J.</creatorcontrib><creatorcontrib>Mathias, J. 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J.</au><au>Mathias, J. L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cognitive functioning in chronic fatigue syndrome: a meta-analysis</atitle><jtitle>Psychological medicine</jtitle><addtitle>Psychol. Med</addtitle><date>2010-08-01</date><risdate>2010</risdate><volume>40</volume><issue>8</issue><spage>1253</spage><epage>1267</epage><pages>1253-1267</pages><issn>0033-2917</issn><eissn>1469-8978</eissn><coden>PSMDCO</coden><abstract>Cognitive problems are commonly reported in persons with chronic fatigue syndrome (CFS) and are one of the most disabling symptoms of this condition. A number of cognitive deficits have been identified, although the findings are inconsistent and hindered by methodological differences. The current study therefore conducted a meta-analysis of research examining cognitive functioning in persons with CFS in order to identify the pattern and magnitude of any deficits that are associated with this condition.
A comprehensive search of the PubMed and PsycINFO databases for studies that examined cognitive functioning in CFS between 1988 and 2008 identified 50 eligible studies. Weighted Cohen's d effect sizes, 95% confidence intervals and fail-safe Ns were calculated for each cognitive score.
Evidence of cognitive deficits in persons with CFS was found primarily in the domains of attention, memory and reaction time. Deficits were not apparent on tests of fine motor speed, vocabulary, reasoning and global functioning.
Persons with CFS demonstrate moderate to large impairments in simple and complex information processing speed and in tasks requiring working memory over a sustained period of time.</abstract><cop>Cambridge, UK</cop><pub>Cambridge University Press</pub><pmid>20047703</pmid><doi>10.1017/S0033291709992054</doi><tpages>15</tpages></addata></record> |
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| ispartof | Psychological medicine, 2010-08, Vol.40 (8), p.1253-1267 |
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| subjects | Adolescent Adult Adult and adolescent clinical studies Aged Attention Biological and medical sciences Chronic fatigue syndrome Cognition & reasoning Cognition Disorders - diagnosis Cognition Disorders - psychology cognitive Cognitive deficits Cognitive functioning Comorbidity Confidence intervals Depressive Disorder - diagnosis Depressive Disorder - psychology Fatigue Syndrome, Chronic - diagnosis Fatigue Syndrome, Chronic - psychology Female Humans Magnitude Male Medical sciences Mental Recall Meta-analysis Middle Aged Miscellaneous Neuropsychological Tests Psychology. Psychoanalysis. Psychiatry Psychomotor Performance Psychopathology. Psychiatry Reaction Time review Systematic review Vocabulary Young Adult |
| title | Cognitive functioning in chronic fatigue syndrome: a meta-analysis |
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