The HMGB protein gene family in zebrafish: Evolution and embryonic expression patterns
The High-Mobility Group Box (HMGB) proteins are highly abundant proteins with both nuclear and extracellular roles in key biological processes. In mammals, three family members are present: HMGB1, HMGB2 and HMGB3. We characterized the HMGB family in zebrafish and report a detailed phylogenetic analy...
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| Veröffentlicht in: | Gene Expression Patterns 2011-01, Vol.11 (1-2), p.3-11 |
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| container_title | Gene Expression Patterns |
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| creator | Moleri, Silvia Cappellano, Giuseppe Gaudenzi, Germano Cermenati, Solei Cotelli, Franco Horner, David S. Beltrame, Monica |
| description | The High-Mobility Group Box (HMGB) proteins are highly abundant proteins with both nuclear and extracellular roles in key biological processes. In mammals, three family members are present: HMGB1, HMGB2 and HMGB3. We characterized the HMGB family in zebrafish and report a detailed phylogenetic analysis of HMGB proteins. The B1, B2, and B3 subfamilies are present in cartilaginous fish, bony fish, and tetrapods, while jawless fish sequences emerge as basal to the gene family expansion. Two co-orthologs of each mammalian HMGB gene are present in zebrafish. All six zebrafish hmgb genes are maternally expressed, but huge differences in expression levels exist during embryonic development. The hmgb2a/hmgb2b genes are the most highly expressed, while hmgb3b is expressed at the lowest level. Remarkably, hmgb3 genes are not present in fugu, medaka, Tetraodon and stickleback. Our analysis highlights substantial overlaps, but also subtle differences and specificities in the expression patterns of the zebrafish hmgb genes. |
| doi_str_mv | 10.1016/j.gep.2010.08.006 |
| format | Article |
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In mammals, three family members are present: HMGB1, HMGB2 and HMGB3. We characterized the HMGB family in zebrafish and report a detailed phylogenetic analysis of HMGB proteins. The B1, B2, and B3 subfamilies are present in cartilaginous fish, bony fish, and tetrapods, while jawless fish sequences emerge as basal to the gene family expansion. Two co-orthologs of each mammalian HMGB gene are present in zebrafish. All six zebrafish hmgb genes are maternally expressed, but huge differences in expression levels exist during embryonic development. The hmgb2a/hmgb2b genes are the most highly expressed, while hmgb3b is expressed at the lowest level. Remarkably, hmgb3 genes are not present in fugu, medaka, Tetraodon and stickleback. Our analysis highlights substantial overlaps, but also subtle differences and specificities in the expression patterns of the zebrafish hmgb genes.</description><identifier>ISSN: 1567-133X</identifier><identifier>EISSN: 1872-7298</identifier><identifier>DOI: 10.1016/j.gep.2010.08.006</identifier><identifier>PMID: 20804857</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Amino Acid Sequence ; Animals ; Chromatin ; Danio rerio ; Development ; Embryonic development ; Evolution, Molecular ; Fish ; Fugu ; Gene expression ; Gene Expression Regulation, Developmental ; Gene family ; High-Mobility group ; High-Mobility Group Box ; HMGB Proteins - chemistry ; HMGB Proteins - genetics ; Humans ; In situ hybridization ; Inflammation ; Innate immunity ; Molecular evolution ; Molecular Sequence Data ; Oryzias latipes ; Phylogenetic analysis ; Phylogeny ; Recombination ; Repair ; Sequence Alignment ; Synteny ; Tetraodon ; Tissue regeneration ; Transcription ; Vertebrates ; Zebrafish - embryology ; Zebrafish - genetics</subject><ispartof>Gene Expression Patterns, 2011-01, Vol.11 (1-2), p.3-11</ispartof><rights>2010 Elsevier B.V.</rights><rights>Copyright © 2010 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c450t-f9d314d1936c8e905465dd9d360675813eebab1535cb9c6e7c3e003b75595b153</citedby><cites>FETCH-LOGICAL-c450t-f9d314d1936c8e905465dd9d360675813eebab1535cb9c6e7c3e003b75595b153</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.gep.2010.08.006$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20804857$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Moleri, Silvia</creatorcontrib><creatorcontrib>Cappellano, Giuseppe</creatorcontrib><creatorcontrib>Gaudenzi, Germano</creatorcontrib><creatorcontrib>Cermenati, Solei</creatorcontrib><creatorcontrib>Cotelli, Franco</creatorcontrib><creatorcontrib>Horner, David S.</creatorcontrib><creatorcontrib>Beltrame, Monica</creatorcontrib><title>The HMGB protein gene family in zebrafish: Evolution and embryonic expression patterns</title><title>Gene Expression Patterns</title><addtitle>Gene Expr Patterns</addtitle><description>The High-Mobility Group Box (HMGB) proteins are highly abundant proteins with both nuclear and extracellular roles in key biological processes. 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| subjects | Amino Acid Sequence Animals Chromatin Danio rerio Development Embryonic development Evolution, Molecular Fish Fugu Gene expression Gene Expression Regulation, Developmental Gene family High-Mobility group High-Mobility Group Box HMGB Proteins - chemistry HMGB Proteins - genetics Humans In situ hybridization Inflammation Innate immunity Molecular evolution Molecular Sequence Data Oryzias latipes Phylogenetic analysis Phylogeny Recombination Repair Sequence Alignment Synteny Tetraodon Tissue regeneration Transcription Vertebrates Zebrafish - embryology Zebrafish - genetics |
| title | The HMGB protein gene family in zebrafish: Evolution and embryonic expression patterns |
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