N, N-Bis-(8-hydroxyquinoline-5-yl methyl)-benzyl substituted amines (HQNBA): Peroxisome proliferator-activated receptor (PPAR-γ) agonists with neuroprotective properties

N, N-Bis-(8-hydroxyquinoline-5-yl methyl)-benzyl substituted amines (HQNBA) are new peroxisome proliferator-activated receptor (PPAR-γ) agonists, which exert neuroprotective effects on lesionned HT22 cells. We report on the neuroprotective effects of N, N-bis-(8-hydroxyquinoline-5-yl methyl)-benzyl...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2010-12, Vol.20 (23), p.6966-6968
Hauptverfasser:	Madonna, Sébastien, Maher, Pamela, Kraus, Jean-Louis
Format:	Artikel
Sprache:	eng
Schlagworte:	Amines - chemistry Amines - pharmacology Animals Antioxidants Biological and medical sciences Cell death Cell Death - drug effects Cell Line Hippocampus - cytology Medical sciences Mice N, N-Bis-(8-hydroxyquinoline-5-yl methyl)-benzyl substituted amines Neurons - drug effects Neuropharmacology Neuroprotection Neuroprotective agent Neuroprotective Agents - chemistry Neuroprotective Agents - pharmacology Oxidative Stress - drug effects Oxyquinoline - chemistry Oxyquinoline - pharmacology Pharmacology. Drug treatments PPAR gamma - agonists PPAR-γ agonists
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