N, N-Bis-(8-hydroxyquinoline-5-yl methyl)-benzyl substituted amines (HQNBA): Peroxisome proliferator-activated receptor (PPAR-γ) agonists with neuroprotective properties
N, N-Bis-(8-hydroxyquinoline-5-yl methyl)-benzyl substituted amines (HQNBA) are new peroxisome proliferator-activated receptor (PPAR-γ) agonists, which exert neuroprotective effects on lesionned HT22 cells. We report on the neuroprotective effects of N, N-bis-(8-hydroxyquinoline-5-yl methyl)-benzyl...
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| Veröffentlicht in: | Bioorganic & medicinal chemistry letters 2010-12, Vol.20 (23), p.6966-6968 |
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| container_issue | 23 |
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| container_title | Bioorganic & medicinal chemistry letters |
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| creator | Madonna, Sébastien Maher, Pamela Kraus, Jean-Louis |
| description | N,
N-Bis-(8-hydroxyquinoline-5-yl methyl)-benzyl substituted amines (HQNBA) are new peroxisome proliferator-activated receptor (PPAR-γ) agonists, which exert neuroprotective effects on lesionned HT22 cells.
We report on the neuroprotective effects of
N,
N-bis-(8-hydroxyquinoline-5-yl methyl)-benzyl substituted amines (HQNBA) in a model of oxidative stress-induced nerve cell death using mouse hippocampal-derived HT22 cells. The four derivatives (JLK1472, JLK1486, JLK1522 and JLK1535) protected the HT22 cells from death at concentrations ranging from 0.1 to 1
μM. Their action is partially dependent on their ability to act as PPARγ agonists. These analogues also maintain GSH levels suggesting that they have indirect anti-oxidant effects. |
| doi_str_mv | 10.1016/j.bmcl.2010.09.134 |
| format | Article |
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N-Bis-(8-hydroxyquinoline-5-yl methyl)-benzyl substituted amines (HQNBA) are new peroxisome proliferator-activated receptor (PPAR-γ) agonists, which exert neuroprotective effects on lesionned HT22 cells.
We report on the neuroprotective effects of
N,
N-bis-(8-hydroxyquinoline-5-yl methyl)-benzyl substituted amines (HQNBA) in a model of oxidative stress-induced nerve cell death using mouse hippocampal-derived HT22 cells. The four derivatives (JLK1472, JLK1486, JLK1522 and JLK1535) protected the HT22 cells from death at concentrations ranging from 0.1 to 1
μM. Their action is partially dependent on their ability to act as PPARγ agonists. These analogues also maintain GSH levels suggesting that they have indirect anti-oxidant effects.</description><identifier>ISSN: 0960-894X</identifier><identifier>EISSN: 1464-3405</identifier><identifier>DOI: 10.1016/j.bmcl.2010.09.134</identifier><identifier>PMID: 20971007</identifier><language>eng</language><publisher>Amsterdam: Elsevier Ltd</publisher><subject>Amines - chemistry ; Amines - pharmacology ; Animals ; Antioxidants ; Biological and medical sciences ; Cell death ; Cell Death - drug effects ; Cell Line ; Hippocampus - cytology ; Medical sciences ; Mice ; N, N-Bis-(8-hydroxyquinoline-5-yl methyl)-benzyl substituted amines ; Neurons - drug effects ; Neuropharmacology ; Neuroprotection ; Neuroprotective agent ; Neuroprotective Agents - chemistry ; Neuroprotective Agents - pharmacology ; Oxidative Stress - drug effects ; Oxyquinoline - chemistry ; Oxyquinoline - pharmacology ; Pharmacology. Drug treatments ; PPAR gamma - agonists ; PPAR-γ agonists</subject><ispartof>Bioorganic & medicinal chemistry letters, 2010-12, Vol.20 (23), p.6966-6968</ispartof><rights>2010 Elsevier Ltd</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2010 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-3a04044fcd83c1158daa4bf448b4a5a5967cb7228c6349f74515120663da09ea3</citedby><cites>FETCH-LOGICAL-c417t-3a04044fcd83c1158daa4bf448b4a5a5967cb7228c6349f74515120663da09ea3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0960894X10014435$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27903,27904,65309</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23428466$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20971007$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Madonna, Sébastien</creatorcontrib><creatorcontrib>Maher, Pamela</creatorcontrib><creatorcontrib>Kraus, Jean-Louis</creatorcontrib><title>N, N-Bis-(8-hydroxyquinoline-5-yl methyl)-benzyl substituted amines (HQNBA): Peroxisome proliferator-activated receptor (PPAR-γ) agonists with neuroprotective properties</title><title>Bioorganic & medicinal chemistry letters</title><addtitle>Bioorg Med Chem Lett</addtitle><description>N,
N-Bis-(8-hydroxyquinoline-5-yl methyl)-benzyl substituted amines (HQNBA) are new peroxisome proliferator-activated receptor (PPAR-γ) agonists, which exert neuroprotective effects on lesionned HT22 cells.
We report on the neuroprotective effects of
N,
N-bis-(8-hydroxyquinoline-5-yl methyl)-benzyl substituted amines (HQNBA) in a model of oxidative stress-induced nerve cell death using mouse hippocampal-derived HT22 cells. The four derivatives (JLK1472, JLK1486, JLK1522 and JLK1535) protected the HT22 cells from death at concentrations ranging from 0.1 to 1
μM. Their action is partially dependent on their ability to act as PPARγ agonists. These analogues also maintain GSH levels suggesting that they have indirect anti-oxidant effects.</description><subject>Amines - chemistry</subject><subject>Amines - pharmacology</subject><subject>Animals</subject><subject>Antioxidants</subject><subject>Biological and medical sciences</subject><subject>Cell death</subject><subject>Cell Death - drug effects</subject><subject>Cell Line</subject><subject>Hippocampus - cytology</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>N, N-Bis-(8-hydroxyquinoline-5-yl methyl)-benzyl substituted amines</subject><subject>Neurons - drug effects</subject><subject>Neuropharmacology</subject><subject>Neuroprotection</subject><subject>Neuroprotective agent</subject><subject>Neuroprotective Agents - chemistry</subject><subject>Neuroprotective Agents - pharmacology</subject><subject>Oxidative Stress - drug effects</subject><subject>Oxyquinoline - chemistry</subject><subject>Oxyquinoline - pharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>PPAR gamma - agonists</subject><subject>PPAR-γ agonists</subject><issn>0960-894X</issn><issn>1464-3405</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkd2OEyEYhonRuLV6Ax4YToxtIhUG5oeNJ92NuiabWo0mnhGG-cbSzE8XmHW7l-Sp9-E1ydiqZ3pEIM_zwseL0GNGF4yy7MV2UbamWSQ0HlC5YFzcQRMmMkG4oOldNKEyo6SQ4vMJeuD9llImqBD30UlCZc4ozSfo2-o5XpEz68msIJt95fqb_dVgu76xHZCU7BvcQtjsmzkpobuNWz-UPtgwBKiwbiPl8ezi_epsOT_Fa4i-9X0LeOdiRA1Oh94RbYK91qPhwMAuHuHZer38QH58n2P9pe-sDx5_tWGDOxhcH-UAo_MrZwcuWPAP0b1aNx4eHdcp-vT61cfzC3L57s3b8-UlMYLlgXBNxylrUxXcMJYWldairIUoSqFTncosN2WeJIXJuJB1LlKWsoRmGa80laD5FD075MarrwbwQbXWG2ga3UE_eFVIyTjLaPJfMs84y4VgaSSTA2lc772DWu2cbbXbK0bVWKbaqrFMNZapqFSxzCg9OcYPZQvVH-V3exF4egS0N7qpne6M9X85LpJCxMGm6OWBg_ht1xac8sZCZ6CysY-gqt7-6x0_AayDv4E</recordid><startdate>20101201</startdate><enddate>20101201</enddate><creator>Madonna, Sébastien</creator><creator>Maher, Pamela</creator><creator>Kraus, Jean-Louis</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QO</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>20101201</creationdate><title>N, N-Bis-(8-hydroxyquinoline-5-yl methyl)-benzyl substituted amines (HQNBA): Peroxisome proliferator-activated receptor (PPAR-γ) agonists with neuroprotective properties</title><author>Madonna, Sébastien ; Maher, Pamela ; Kraus, Jean-Louis</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-3a04044fcd83c1158daa4bf448b4a5a5967cb7228c6349f74515120663da09ea3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Amines - chemistry</topic><topic>Amines - pharmacology</topic><topic>Animals</topic><topic>Antioxidants</topic><topic>Biological and medical sciences</topic><topic>Cell death</topic><topic>Cell Death - drug effects</topic><topic>Cell Line</topic><topic>Hippocampus - cytology</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>N, N-Bis-(8-hydroxyquinoline-5-yl methyl)-benzyl substituted amines</topic><topic>Neurons - drug effects</topic><topic>Neuropharmacology</topic><topic>Neuroprotection</topic><topic>Neuroprotective agent</topic><topic>Neuroprotective Agents - chemistry</topic><topic>Neuroprotective Agents - pharmacology</topic><topic>Oxidative Stress - drug effects</topic><topic>Oxyquinoline - chemistry</topic><topic>Oxyquinoline - pharmacology</topic><topic>Pharmacology. Drug treatments</topic><topic>PPAR gamma - agonists</topic><topic>PPAR-γ agonists</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Madonna, Sébastien</creatorcontrib><creatorcontrib>Maher, Pamela</creatorcontrib><creatorcontrib>Kraus, Jean-Louis</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Biotechnology Research Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Bioorganic & medicinal chemistry letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Madonna, Sébastien</au><au>Maher, Pamela</au><au>Kraus, Jean-Louis</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>N, N-Bis-(8-hydroxyquinoline-5-yl methyl)-benzyl substituted amines (HQNBA): Peroxisome proliferator-activated receptor (PPAR-γ) agonists with neuroprotective properties</atitle><jtitle>Bioorganic & medicinal chemistry letters</jtitle><addtitle>Bioorg Med Chem Lett</addtitle><date>2010-12-01</date><risdate>2010</risdate><volume>20</volume><issue>23</issue><spage>6966</spage><epage>6968</epage><pages>6966-6968</pages><issn>0960-894X</issn><eissn>1464-3405</eissn><abstract>N,
N-Bis-(8-hydroxyquinoline-5-yl methyl)-benzyl substituted amines (HQNBA) are new peroxisome proliferator-activated receptor (PPAR-γ) agonists, which exert neuroprotective effects on lesionned HT22 cells.
We report on the neuroprotective effects of
N,
N-bis-(8-hydroxyquinoline-5-yl methyl)-benzyl substituted amines (HQNBA) in a model of oxidative stress-induced nerve cell death using mouse hippocampal-derived HT22 cells. The four derivatives (JLK1472, JLK1486, JLK1522 and JLK1535) protected the HT22 cells from death at concentrations ranging from 0.1 to 1
μM. Their action is partially dependent on their ability to act as PPARγ agonists. These analogues also maintain GSH levels suggesting that they have indirect anti-oxidant effects.</abstract><cop>Amsterdam</cop><pub>Elsevier Ltd</pub><pmid>20971007</pmid><doi>10.1016/j.bmcl.2010.09.134</doi><tpages>3</tpages></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Amines - chemistry Amines - pharmacology Animals Antioxidants Biological and medical sciences Cell death Cell Death - drug effects Cell Line Hippocampus - cytology Medical sciences Mice N, N-Bis-(8-hydroxyquinoline-5-yl methyl)-benzyl substituted amines Neurons - drug effects Neuropharmacology Neuroprotection Neuroprotective agent Neuroprotective Agents - chemistry Neuroprotective Agents - pharmacology Oxidative Stress - drug effects Oxyquinoline - chemistry Oxyquinoline - pharmacology Pharmacology. Drug treatments PPAR gamma - agonists PPAR-γ agonists |
| title | N, N-Bis-(8-hydroxyquinoline-5-yl methyl)-benzyl substituted amines (HQNBA): Peroxisome proliferator-activated receptor (PPAR-γ) agonists with neuroprotective properties |
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