Anti-insulin-like growth factor 1 receptor antibody EM164 (murine AVE1642) exhibits anti-tumour activity alone and in combination with temozolomide against neuroblastoma

Abstract Insulin-like growth factor 1 receptor (IGF-1R) is overexpressed in many tumours and contributes to tumourigenicity, cell proliferation, metastasis and resistance, thus representing a promising therapeutic target. The human IGF-1R antagonistic monoclonal antibody EM164 (murine AVE1642) has s...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	European journal of cancer (1990) 2010-12, Vol.46 (18), p.3251-3262
Hauptverfasser:	Geoerger, Birgit, Brasme, Jean-François, Daudigeos-Dubus, Estelle, Opolon, Paule, Venot, Corinne, Debussche, Laurent, Vrignaud, Patricia, Vassal, Gilles
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkylating agents Animals Antibodies, Monoclonal - administration & dosage Antibodies, Monoclonal - therapeutic use Antibodies, Monoclonal, Humanized Antineoplastic Agents, Alkylating - administration & dosage Antineoplastic Agents, Alkylating - therapeutic use Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biological and medical sciences Cell Line, Tumor Cell Proliferation - drug effects Dacarbazine - administration & dosage Dacarbazine - analogs & derivatives Female Hematology, Oncology and Palliative Medicine Humans Insulin-like growth factor pathway Medical sciences Mice Mice, Nude Mitogen-Activated Protein Kinases - drug effects Monoclonal antibodies/therapeutic use Neuroblastoma - drug therapy Pediatric cancer Pharmacology. Drug treatments Proto-Oncogene Proteins c-akt - drug effects Receptor, IGF Type 1 - antagonists & inhibitors Retinoid acid Sympathic nervous system tumours Tumors Xenograft Model Antitumor Assays - methods
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!