Decreased pituitary response to insulin-induced hypoglycaemia in young lean male patients with essential hypertension
Essential hypertension is associated with changes in central catecholaminergic pathways which might also be reflected in the pituitary response to stress stimuli. The aim of this study was to determine whether the response of pituitary hormones, cortisol, plasma renin activity, aldosterone and catec...
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| Veröffentlicht in: | Journal of human hypertension 2006-07, Vol.20 (7), p.510-516 |
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| creator | Radikova, Z Penesova, A Cizmarova, E Huckova, M Kvetnansky, R Vigas, M Koska, J |
| description | Essential hypertension is associated with changes in central catecholaminergic pathways which might also be reflected in the pituitary response to stress stimuli. The aim of this study was to determine whether the response of pituitary hormones, cortisol, plasma renin activity, aldosterone and catecholamines to insulin-induced hypoglycaemia is changed in hypertension. We studied 22 young lean male patients with newly diagnosed untreated essential hypertension and 19 healthy normotensive, age- and body mass index (BMI)-matched controls. All subjects underwent an insulin tolerance test (0.1 IU insulin/kg body weight intravenously) with blood sampling before and 15, 30, 45, 60 and 90 min after insulin administration. Increased baseline levels of norepinephrine (
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| doi_str_mv | 10.1038/sj.jhh.1002026 |
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P
<0.05), increased response of norepinephrine (
P
<0.001) and decreased response of growth hormone (
P
<0.001), prolactin (
P
<0.001), adrenocorticotropic hormone (
P
<0.05) and cortisol (
P
<0.001) were found in hypertensive patients when compared to normotensive controls. Increased norepinephrine levels and a decreased pituitary response to metabolic stress stimuli may represent another manifestation of chronically increased sympathetic tone in early hypertension.]]></description><identifier>ISSN: 0950-9240</identifier><identifier>EISSN: 1476-5527</identifier><identifier>DOI: 10.1038/sj.jhh.1002026</identifier><identifier>PMID: 16617309</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>ACTH ; Adrenocorticotropic hormone ; Adult ; Aldosterone ; Aldosterone - blood ; Arterial hypertension. Arterial hypotension ; Biological and medical sciences ; Blood and lymphatic vessels ; Blood Glucose - metabolism ; Blood Pressure - physiology ; Body mass index ; Body weight ; Cardiology. Vascular system ; Case-Control Studies ; Catecholamines ; Clinical manifestations. Epidemiology. Investigative techniques. Etiology ; Complications and side effects ; Cortisol ; Diagnosis ; Epidemiology ; Epinephrine - blood ; Essential hypertension ; Experimental diseases ; Growth Hormone - blood ; Growth hormones ; Health Administration ; Heart Rate - physiology ; Humans ; Hypertension ; Hypertension - blood ; Hypertension - physiopathology ; Hypoglycemia ; Hypoglycemia - blood ; Hypoglycemia - chemically induced ; Hypoglycemic Agents - pharmacology ; Insulin ; Insulin - pharmacology ; Male ; Medical sciences ; Medicine ; Medicine & Public Health ; Norepinephrine ; Norepinephrine - blood ; original-article ; Physiological aspects ; Pituitary ; Pituitary Gland - drug effects ; Pituitary Gland - metabolism ; Pituitary hormones ; Prolactin ; Public Health ; Renin ; Renin - blood ; Risk factors ; Sympathetic nervous system ; Thinness - blood ; Thinness - physiopathology</subject><ispartof>Journal of human hypertension, 2006-07, Vol.20 (7), p.510-516</ispartof><rights>Springer Nature Limited 2006</rights><rights>2006 INIST-CNRS</rights><rights>COPYRIGHT 2006 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Jul 2006</rights><rights>Nature Publishing Group 2006.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c570t-cab340d7182c1622a7a9004af7930038a93fe3b346d73f21d362ec5e03c2113</citedby><cites>FETCH-LOGICAL-c570t-cab340d7182c1622a7a9004af7930038a93fe3b346d73f21d362ec5e03c2113</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17863763$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16617309$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Radikova, Z</creatorcontrib><creatorcontrib>Penesova, A</creatorcontrib><creatorcontrib>Cizmarova, E</creatorcontrib><creatorcontrib>Huckova, M</creatorcontrib><creatorcontrib>Kvetnansky, R</creatorcontrib><creatorcontrib>Vigas, M</creatorcontrib><creatorcontrib>Koska, J</creatorcontrib><title>Decreased pituitary response to insulin-induced hypoglycaemia in young lean male patients with essential hypertension</title><title>Journal of human hypertension</title><addtitle>J Hum Hypertens</addtitle><addtitle>J Hum Hypertens</addtitle><description><![CDATA[Essential hypertension is associated with changes in central catecholaminergic pathways which might also be reflected in the pituitary response to stress stimuli. The aim of this study was to determine whether the response of pituitary hormones, cortisol, plasma renin activity, aldosterone and catecholamines to insulin-induced hypoglycaemia is changed in hypertension. We studied 22 young lean male patients with newly diagnosed untreated essential hypertension and 19 healthy normotensive, age- and body mass index (BMI)-matched controls. All subjects underwent an insulin tolerance test (0.1 IU insulin/kg body weight intravenously) with blood sampling before and 15, 30, 45, 60 and 90 min after insulin administration. Increased baseline levels of norepinephrine (
P
<0.05), increased response of norepinephrine (
P
<0.001) and decreased response of growth hormone (
P
<0.001), prolactin (
P
<0.001), adrenocorticotropic hormone (
P
<0.05) and cortisol (
P
<0.001) were found in hypertensive patients when compared to normotensive controls. Increased norepinephrine levels and a decreased pituitary response to metabolic stress stimuli may represent another manifestation of chronically increased sympathetic tone in early hypertension.]]></description><subject>ACTH</subject><subject>Adrenocorticotropic hormone</subject><subject>Adult</subject><subject>Aldosterone</subject><subject>Aldosterone - blood</subject><subject>Arterial hypertension. Arterial hypotension</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Blood Glucose - metabolism</subject><subject>Blood Pressure - physiology</subject><subject>Body mass index</subject><subject>Body weight</subject><subject>Cardiology. Vascular system</subject><subject>Case-Control Studies</subject><subject>Catecholamines</subject><subject>Clinical manifestations. Epidemiology. Investigative techniques. Etiology</subject><subject>Complications and side effects</subject><subject>Cortisol</subject><subject>Diagnosis</subject><subject>Epidemiology</subject><subject>Epinephrine - blood</subject><subject>Essential hypertension</subject><subject>Experimental diseases</subject><subject>Growth Hormone - blood</subject><subject>Growth hormones</subject><subject>Health Administration</subject><subject>Heart Rate - physiology</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Hypertension - blood</subject><subject>Hypertension - physiopathology</subject><subject>Hypoglycemia</subject><subject>Hypoglycemia - blood</subject><subject>Hypoglycemia - chemically induced</subject><subject>Hypoglycemic Agents - pharmacology</subject><subject>Insulin</subject><subject>Insulin - pharmacology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Norepinephrine</subject><subject>Norepinephrine - blood</subject><subject>original-article</subject><subject>Physiological aspects</subject><subject>Pituitary</subject><subject>Pituitary Gland - drug effects</subject><subject>Pituitary Gland - metabolism</subject><subject>Pituitary hormones</subject><subject>Prolactin</subject><subject>Public Health</subject><subject>Renin</subject><subject>Renin - blood</subject><subject>Risk factors</subject><subject>Sympathetic nervous system</subject><subject>Thinness - blood</subject><subject>Thinness - physiopathology</subject><issn>0950-9240</issn><issn>1476-5527</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kstv1DAQhyMEoqVw5QaKQMApWz8SJz5W5SlV4gB3y3UmG6-8dvDYqva_x6tdaQtq5YMf8_3m5amq15SsKOHDJW5Wm3kuZ8IIE0-qc9r2ouk61j-tzonsSCNZS86qF4gbQvbG4Xl1RoWgPSfyvMqfwUTQCGO92JRt0nFXR8AleIQ6hdp6zM76xvoxm0LNuyWs3c5o2FpdrPUuZL-uHWhfb7WDetHJgk9Y39k014BYLla7vRBiAo82-JfVs0k7hFfH_aL69fXL7-vvzc3Pbz-ur24a0_UkNUbf8paMPR2YoYIx3WtJSKunXnJSqteST8ALI8aeT4yOXDAwHRBuGKX8ovp08LrE8CcDJrW1aMA57SFkVIOUlMm2Y4V8_x-5CTn6kppioiWd6OjQFurdoxSVUrSciJOrdWmGsn4KKWqzD6yu6MA5F63cu1o9QJU1lraa4GGy5f0fwcd7ghm0SzMGl1PpJj7o2cSAGGFSS7Tb8quKErUfGYUbVUZGHUemCN4eq8q3WxhP-HFGCvDhCGg02k1Re2PxxPWD4L3ghbs8cFhMfg3x1J5HQ785KLxOOcK9TA_2v7u24ao</recordid><startdate>20060701</startdate><enddate>20060701</enddate><creator>Radikova, Z</creator><creator>Penesova, A</creator><creator>Cizmarova, E</creator><creator>Huckova, M</creator><creator>Kvetnansky, R</creator><creator>Vigas, M</creator><creator>Koska, J</creator><general>Nature Publishing Group UK</general><general>Nature Publishing</general><general>Nature Publishing Group</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7TK</scope></search><sort><creationdate>20060701</creationdate><title>Decreased pituitary response to insulin-induced hypoglycaemia in young lean male patients with essential hypertension</title><author>Radikova, Z ; Penesova, A ; Cizmarova, E ; Huckova, M ; Kvetnansky, R ; Vigas, M ; Koska, J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c570t-cab340d7182c1622a7a9004af7930038a93fe3b346d73f21d362ec5e03c2113</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>ACTH</topic><topic>Adrenocorticotropic hormone</topic><topic>Adult</topic><topic>Aldosterone</topic><topic>Aldosterone - blood</topic><topic>Arterial hypertension. Arterial hypotension</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Blood Glucose - metabolism</topic><topic>Blood Pressure - physiology</topic><topic>Body mass index</topic><topic>Body weight</topic><topic>Cardiology. Vascular system</topic><topic>Case-Control Studies</topic><topic>Catecholamines</topic><topic>Clinical manifestations. Epidemiology. Investigative techniques. Etiology</topic><topic>Complications and side effects</topic><topic>Cortisol</topic><topic>Diagnosis</topic><topic>Epidemiology</topic><topic>Epinephrine - blood</topic><topic>Essential hypertension</topic><topic>Experimental diseases</topic><topic>Growth Hormone - blood</topic><topic>Growth hormones</topic><topic>Health Administration</topic><topic>Heart Rate - physiology</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Hypertension - blood</topic><topic>Hypertension - physiopathology</topic><topic>Hypoglycemia</topic><topic>Hypoglycemia - blood</topic><topic>Hypoglycemia - chemically induced</topic><topic>Hypoglycemic Agents - pharmacology</topic><topic>Insulin</topic><topic>Insulin - pharmacology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Norepinephrine</topic><topic>Norepinephrine - blood</topic><topic>original-article</topic><topic>Physiological aspects</topic><topic>Pituitary</topic><topic>Pituitary Gland - drug effects</topic><topic>Pituitary Gland - metabolism</topic><topic>Pituitary hormones</topic><topic>Prolactin</topic><topic>Public Health</topic><topic>Renin</topic><topic>Renin - blood</topic><topic>Risk factors</topic><topic>Sympathetic nervous system</topic><topic>Thinness - blood</topic><topic>Thinness - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Radikova, Z</creatorcontrib><creatorcontrib>Penesova, A</creatorcontrib><creatorcontrib>Cizmarova, E</creatorcontrib><creatorcontrib>Huckova, M</creatorcontrib><creatorcontrib>Kvetnansky, R</creatorcontrib><creatorcontrib>Vigas, M</creatorcontrib><creatorcontrib>Koska, J</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Neurosciences Abstracts</collection><jtitle>Journal of human hypertension</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Radikova, Z</au><au>Penesova, A</au><au>Cizmarova, E</au><au>Huckova, M</au><au>Kvetnansky, R</au><au>Vigas, M</au><au>Koska, J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Decreased pituitary response to insulin-induced hypoglycaemia in young lean male patients with essential hypertension</atitle><jtitle>Journal of human hypertension</jtitle><stitle>J Hum Hypertens</stitle><addtitle>J Hum Hypertens</addtitle><date>2006-07-01</date><risdate>2006</risdate><volume>20</volume><issue>7</issue><spage>510</spage><epage>516</epage><pages>510-516</pages><issn>0950-9240</issn><eissn>1476-5527</eissn><abstract><![CDATA[Essential hypertension is associated with changes in central catecholaminergic pathways which might also be reflected in the pituitary response to stress stimuli. The aim of this study was to determine whether the response of pituitary hormones, cortisol, plasma renin activity, aldosterone and catecholamines to insulin-induced hypoglycaemia is changed in hypertension. We studied 22 young lean male patients with newly diagnosed untreated essential hypertension and 19 healthy normotensive, age- and body mass index (BMI)-matched controls. All subjects underwent an insulin tolerance test (0.1 IU insulin/kg body weight intravenously) with blood sampling before and 15, 30, 45, 60 and 90 min after insulin administration. Increased baseline levels of norepinephrine (
P
<0.05), increased response of norepinephrine (
P
<0.001) and decreased response of growth hormone (
P
<0.001), prolactin (
P
<0.001), adrenocorticotropic hormone (
P
<0.05) and cortisol (
P
<0.001) were found in hypertensive patients when compared to normotensive controls. Increased norepinephrine levels and a decreased pituitary response to metabolic stress stimuli may represent another manifestation of chronically increased sympathetic tone in early hypertension.]]></abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>16617309</pmid><doi>10.1038/sj.jhh.1002026</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of human hypertension, 2006-07, Vol.20 (7), p.510-516 |
| issn | 0950-9240 1476-5527 |
| language | eng |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | ACTH Adrenocorticotropic hormone Adult Aldosterone Aldosterone - blood Arterial hypertension. Arterial hypotension Biological and medical sciences Blood and lymphatic vessels Blood Glucose - metabolism Blood Pressure - physiology Body mass index Body weight Cardiology. Vascular system Case-Control Studies Catecholamines Clinical manifestations. Epidemiology. Investigative techniques. Etiology Complications and side effects Cortisol Diagnosis Epidemiology Epinephrine - blood Essential hypertension Experimental diseases Growth Hormone - blood Growth hormones Health Administration Heart Rate - physiology Humans Hypertension Hypertension - blood Hypertension - physiopathology Hypoglycemia Hypoglycemia - blood Hypoglycemia - chemically induced Hypoglycemic Agents - pharmacology Insulin Insulin - pharmacology Male Medical sciences Medicine Medicine & Public Health Norepinephrine Norepinephrine - blood original-article Physiological aspects Pituitary Pituitary Gland - drug effects Pituitary Gland - metabolism Pituitary hormones Prolactin Public Health Renin Renin - blood Risk factors Sympathetic nervous system Thinness - blood Thinness - physiopathology |
| title | Decreased pituitary response to insulin-induced hypoglycaemia in young lean male patients with essential hypertension |
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