B cell immunosenescence: different features of naive and memory B cells in elderly
Elderly people show a reduced protection against new infections and a decreased response to vaccines as a consequence of impairment of both cellular and humoral immunity. In this paper we have studied memory/naïve B cells in the elderly, evaluating surface immunoglobulin expression, production of th...
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| Veröffentlicht in: | Biogerontology (Dordrecht) 2011-10, Vol.12 (5), p.473-483 |
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| creator | Buffa, Silvio Bulati, Matteo Pellicanò, Mariavaleria Dunn-Walters, Deborah K. Wu, Yu-Chang Candore, Giuseppina Vitello, Salvatore Caruso, Calogero Colonna-Romano, Giuseppina |
| description | Elderly people show a reduced protection against new infections and a decreased response to vaccines as a consequence of impairment of both cellular and humoral immunity. In this paper we have studied memory/naïve B cells in the elderly, evaluating surface immunoglobulin expression, production of the pro- and anti-inflammatory cytokines, tumor necrosis factor (TNF)-α and interleukin (IL)-10, and presence of somatic hypermutation, focusing on the IgG
+
IgD
−
CD27
−
double negative (DN) B cells that are expanded in the elderly. Our results show that naïve B cells from young donors need a sufficiently strong stimulus to be activated “in vitro”, while naïve B cells from old subjects are able to produce IL-10 and TNF-α when stimulated “physiologically” (α-CD40/IL-4), suggesting that these cells might play a role in the control of the immuno-inflammatory environment in the elderly. In addition, in the elderly there is an accumulation of DN B cells with a reduced rate of somatic hypermutation. Thus, DN B lymphocytes may be exhausted cells that are expanded and accumulate as a by-product of persistent stimulation or impaired germinal center formation. |
| doi_str_mv | 10.1007/s10522-011-9353-4 |
| format | Article |
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+
IgD
−
CD27
−
double negative (DN) B cells that are expanded in the elderly. Our results show that naïve B cells from young donors need a sufficiently strong stimulus to be activated “in vitro”, while naïve B cells from old subjects are able to produce IL-10 and TNF-α when stimulated “physiologically” (α-CD40/IL-4), suggesting that these cells might play a role in the control of the immuno-inflammatory environment in the elderly. In addition, in the elderly there is an accumulation of DN B cells with a reduced rate of somatic hypermutation. Thus, DN B lymphocytes may be exhausted cells that are expanded and accumulate as a by-product of persistent stimulation or impaired germinal center formation.</description><identifier>ISSN: 1389-5729</identifier><identifier>EISSN: 1573-6768</identifier><identifier>DOI: 10.1007/s10522-011-9353-4</identifier><identifier>PMID: 21879287</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Antigens ; B-Lymphocytes - cytology ; B-Lymphocytes - drug effects ; B-Lymphocytes - immunology ; Biomedical and Life Sciences ; Cell Biology ; Cells ; Cellular Senescence - immunology ; Cytokines ; Developmental Biology ; Geriatrics ; Geriatrics/Gerontology ; Germinal centers ; Humans ; Immune system ; Immunity (humoral) ; Immunoglobulins ; Immunoglobulins - immunology ; Immunologic Memory ; Immunological memory ; Immunology ; Immunosenescence ; Infection ; Inflammation ; Interleukin 10 ; Interleukin 4 ; Interleukin-10 - biosynthesis ; Ionomycin - pharmacology ; Laboratories ; Life Sciences ; Lymphocyte Activation ; Lymphocytes ; Lymphocytes B ; Memory cells ; Middle Aged ; Older people ; Research Paper ; somatic hypermutation ; Tetradecanoylphorbol Acetate - pharmacology ; Tumor necrosis factor- alpha ; Tumor necrosis factor-TNF ; Vaccines</subject><ispartof>Biogerontology (Dordrecht), 2011-10, Vol.12 (5), p.473-483</ispartof><rights>Springer Science+Business Media B.V. 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c446t-ccd31226fd6a2460a5fc2697226da8449309968dd69fa84375c6a5e8a7d7eda73</citedby><cites>FETCH-LOGICAL-c446t-ccd31226fd6a2460a5fc2697226da8449309968dd69fa84375c6a5e8a7d7eda73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10522-011-9353-4$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10522-011-9353-4$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21879287$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Buffa, Silvio</creatorcontrib><creatorcontrib>Bulati, Matteo</creatorcontrib><creatorcontrib>Pellicanò, Mariavaleria</creatorcontrib><creatorcontrib>Dunn-Walters, Deborah K.</creatorcontrib><creatorcontrib>Wu, Yu-Chang</creatorcontrib><creatorcontrib>Candore, Giuseppina</creatorcontrib><creatorcontrib>Vitello, Salvatore</creatorcontrib><creatorcontrib>Caruso, Calogero</creatorcontrib><creatorcontrib>Colonna-Romano, Giuseppina</creatorcontrib><title>B cell immunosenescence: different features of naive and memory B cells in elderly</title><title>Biogerontology (Dordrecht)</title><addtitle>Biogerontology</addtitle><addtitle>Biogerontology</addtitle><description>Elderly people show a reduced protection against new infections and a decreased response to vaccines as a consequence of impairment of both cellular and humoral immunity. In this paper we have studied memory/naïve B cells in the elderly, evaluating surface immunoglobulin expression, production of the pro- and anti-inflammatory cytokines, tumor necrosis factor (TNF)-α and interleukin (IL)-10, and presence of somatic hypermutation, focusing on the IgG
+
IgD
−
CD27
−
double negative (DN) B cells that are expanded in the elderly. Our results show that naïve B cells from young donors need a sufficiently strong stimulus to be activated “in vitro”, while naïve B cells from old subjects are able to produce IL-10 and TNF-α when stimulated “physiologically” (α-CD40/IL-4), suggesting that these cells might play a role in the control of the immuno-inflammatory environment in the elderly. In addition, in the elderly there is an accumulation of DN B cells with a reduced rate of somatic hypermutation. Thus, DN B lymphocytes may be exhausted cells that are expanded and accumulate as a by-product of persistent stimulation or impaired germinal center formation.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Antigens</subject><subject>B-Lymphocytes - cytology</subject><subject>B-Lymphocytes - drug effects</subject><subject>B-Lymphocytes - immunology</subject><subject>Biomedical and Life Sciences</subject><subject>Cell Biology</subject><subject>Cells</subject><subject>Cellular Senescence - immunology</subject><subject>Cytokines</subject><subject>Developmental Biology</subject><subject>Geriatrics</subject><subject>Geriatrics/Gerontology</subject><subject>Germinal centers</subject><subject>Humans</subject><subject>Immune system</subject><subject>Immunity (humoral)</subject><subject>Immunoglobulins</subject><subject>Immunoglobulins - immunology</subject><subject>Immunologic Memory</subject><subject>Immunological memory</subject><subject>Immunology</subject><subject>Immunosenescence</subject><subject>Infection</subject><subject>Inflammation</subject><subject>Interleukin 10</subject><subject>Interleukin 4</subject><subject>Interleukin-10 - biosynthesis</subject><subject>Ionomycin - pharmacology</subject><subject>Laboratories</subject><subject>Life Sciences</subject><subject>Lymphocyte Activation</subject><subject>Lymphocytes</subject><subject>Lymphocytes B</subject><subject>Memory cells</subject><subject>Middle Aged</subject><subject>Older people</subject><subject>Research Paper</subject><subject>somatic hypermutation</subject><subject>Tetradecanoylphorbol Acetate - pharmacology</subject><subject>Tumor necrosis factor- alpha</subject><subject>Tumor necrosis factor-TNF</subject><subject>Vaccines</subject><issn>1389-5729</issn><issn>1573-6768</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kUtLHTEYhoNUvLU_oBsJ3ehmNPeLOxVvIAilXQ9p8qXMYSZzTGaE8-_NYWwFoV3l9rxPEl6EvlJyRgnR54USyVhDKG0sl7wRO-iASs0bpZX5VOfc2EZqZvfRYSkrQqhiSu6hfUaNtszoA_T9Cnvoe9wNw5zGAgmKh-ThAocuRsiQJhzBTXOGgseIk-teALsU8ADDmDd4yRfcJQx9gNxvPqPd6PoCX97GI_Tz9ubH9X3z-HT3cH352Hgh1NR4HzhlTMWgHBOKOBk9U1bXreCMEJYTa5UJQdlY11xLr5wE43TQEJzmR-hk8a7z-DxDmdqhK9vHuATjXFpjjeFWcF7J0_-SlFguhGZEVfTbB3Q1zjnVf2x9QkulZYXoAvk8lpIhtuvcDS5vqqndNtMuzbS1mXbbTCtq5vhNPP8aIPxN_KmiAmwBSj1KvyG_3_xv6ys_SpdD</recordid><startdate>20111001</startdate><enddate>20111001</enddate><creator>Buffa, Silvio</creator><creator>Bulati, Matteo</creator><creator>Pellicanò, Mariavaleria</creator><creator>Dunn-Walters, Deborah K.</creator><creator>Wu, Yu-Chang</creator><creator>Candore, Giuseppina</creator><creator>Vitello, Salvatore</creator><creator>Caruso, Calogero</creator><creator>Colonna-Romano, Giuseppina</creator><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0-V</scope><scope>3V.</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88J</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ALSLI</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2R</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20111001</creationdate><title>B cell immunosenescence: different features of naive and memory B cells in elderly</title><author>Buffa, Silvio ; Bulati, Matteo ; Pellicanò, Mariavaleria ; Dunn-Walters, Deborah K. ; Wu, Yu-Chang ; Candore, Giuseppina ; Vitello, Salvatore ; Caruso, Calogero ; Colonna-Romano, Giuseppina</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c446t-ccd31226fd6a2460a5fc2697226da8449309968dd69fa84375c6a5e8a7d7eda73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Antigens</topic><topic>B-Lymphocytes - cytology</topic><topic>B-Lymphocytes - drug effects</topic><topic>B-Lymphocytes - immunology</topic><topic>Biomedical and Life Sciences</topic><topic>Cell Biology</topic><topic>Cells</topic><topic>Cellular Senescence - immunology</topic><topic>Cytokines</topic><topic>Developmental Biology</topic><topic>Geriatrics</topic><topic>Geriatrics/Gerontology</topic><topic>Germinal centers</topic><topic>Humans</topic><topic>Immune system</topic><topic>Immunity (humoral)</topic><topic>Immunoglobulins</topic><topic>Immunoglobulins - immunology</topic><topic>Immunologic Memory</topic><topic>Immunological memory</topic><topic>Immunology</topic><topic>Immunosenescence</topic><topic>Infection</topic><topic>Inflammation</topic><topic>Interleukin 10</topic><topic>Interleukin 4</topic><topic>Interleukin-10 - biosynthesis</topic><topic>Ionomycin - pharmacology</topic><topic>Laboratories</topic><topic>Life Sciences</topic><topic>Lymphocyte Activation</topic><topic>Lymphocytes</topic><topic>Lymphocytes B</topic><topic>Memory cells</topic><topic>Middle Aged</topic><topic>Older people</topic><topic>Research Paper</topic><topic>somatic hypermutation</topic><topic>Tetradecanoylphorbol Acetate - pharmacology</topic><topic>Tumor necrosis factor- alpha</topic><topic>Tumor necrosis factor-TNF</topic><topic>Vaccines</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Buffa, Silvio</creatorcontrib><creatorcontrib>Bulati, Matteo</creatorcontrib><creatorcontrib>Pellicanò, Mariavaleria</creatorcontrib><creatorcontrib>Dunn-Walters, Deborah K.</creatorcontrib><creatorcontrib>Wu, Yu-Chang</creatorcontrib><creatorcontrib>Candore, Giuseppina</creatorcontrib><creatorcontrib>Vitello, Salvatore</creatorcontrib><creatorcontrib>Caruso, Calogero</creatorcontrib><creatorcontrib>Colonna-Romano, Giuseppina</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Social Sciences Premium Collection</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Social Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Social Science Premium Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Social Science Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Biogerontology (Dordrecht)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Buffa, Silvio</au><au>Bulati, Matteo</au><au>Pellicanò, Mariavaleria</au><au>Dunn-Walters, Deborah K.</au><au>Wu, Yu-Chang</au><au>Candore, Giuseppina</au><au>Vitello, Salvatore</au><au>Caruso, Calogero</au><au>Colonna-Romano, Giuseppina</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>B cell immunosenescence: different features of naive and memory B cells in elderly</atitle><jtitle>Biogerontology (Dordrecht)</jtitle><stitle>Biogerontology</stitle><addtitle>Biogerontology</addtitle><date>2011-10-01</date><risdate>2011</risdate><volume>12</volume><issue>5</issue><spage>473</spage><epage>483</epage><pages>473-483</pages><issn>1389-5729</issn><eissn>1573-6768</eissn><abstract>Elderly people show a reduced protection against new infections and a decreased response to vaccines as a consequence of impairment of both cellular and humoral immunity. In this paper we have studied memory/naïve B cells in the elderly, evaluating surface immunoglobulin expression, production of the pro- and anti-inflammatory cytokines, tumor necrosis factor (TNF)-α and interleukin (IL)-10, and presence of somatic hypermutation, focusing on the IgG
+
IgD
−
CD27
−
double negative (DN) B cells that are expanded in the elderly. Our results show that naïve B cells from young donors need a sufficiently strong stimulus to be activated “in vitro”, while naïve B cells from old subjects are able to produce IL-10 and TNF-α when stimulated “physiologically” (α-CD40/IL-4), suggesting that these cells might play a role in the control of the immuno-inflammatory environment in the elderly. In addition, in the elderly there is an accumulation of DN B cells with a reduced rate of somatic hypermutation. Thus, DN B lymphocytes may be exhausted cells that are expanded and accumulate as a by-product of persistent stimulation or impaired germinal center formation.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>21879287</pmid><doi>10.1007/s10522-011-9353-4</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Antigens B-Lymphocytes - cytology B-Lymphocytes - drug effects B-Lymphocytes - immunology Biomedical and Life Sciences Cell Biology Cells Cellular Senescence - immunology Cytokines Developmental Biology Geriatrics Geriatrics/Gerontology Germinal centers Humans Immune system Immunity (humoral) Immunoglobulins Immunoglobulins - immunology Immunologic Memory Immunological memory Immunology Immunosenescence Infection Inflammation Interleukin 10 Interleukin 4 Interleukin-10 - biosynthesis Ionomycin - pharmacology Laboratories Life Sciences Lymphocyte Activation Lymphocytes Lymphocytes B Memory cells Middle Aged Older people Research Paper somatic hypermutation Tetradecanoylphorbol Acetate - pharmacology Tumor necrosis factor- alpha Tumor necrosis factor-TNF Vaccines |
| title | B cell immunosenescence: different features of naive and memory B cells in elderly |
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