A prospective study of lymphocyte subpopulations and regulatory T cells in patients with chronic hepatitis C virus infection developing interferon-induced thyroiditis
Summary Objective One of the side effects of interferon‐alpha (IFN‐α) therapy is interferon‐induced thyroiditis (IIT). The role of lymphocyte subpopulations in IIT remains to be defined. The aim of this study was to assess different peripheral blood lymphocyte subpopulations, mainly CD4+CD25+CD127l...
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| Veröffentlicht in: | Clinical endocrinology (Oxford) 2011-10, Vol.75 (4), p.535-543 |
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| creator | Soldevila, Berta Alonso, Núria Martínez-Arconada, Maria J. Granada, Maria L. Baía, Diogo Vallejos, Virginia Fraile, Manuel Morillas, Rosa M. Planas, Ramon Pujol-Borrell, Ricardo Martínez-Cáceres, Eva M. Sanmartí, Anna M. |
| description | Summary
Objective One of the side effects of interferon‐alpha (IFN‐α) therapy is interferon‐induced thyroiditis (IIT). The role of lymphocyte subpopulations in IIT remains to be defined. The aim of this study was to assess different peripheral blood lymphocyte subpopulations, mainly CD4+CD25+CD127low/‐FoxP3+ regulatory T cells (Tregs), in patients with chronic hepatitis C virus (HCV) infection who developed IIT.
Design, patients and methods From 120 patients with chronic HCV who started antiviral treatment, those who developed IIT (IIT patients) were selected and compared with patients who did not develop IIT (Co‐HCV). Peripheral blood mononuclear cells were obtained before treatment (BT), mid‐treatment (MT), end of treatment (ET), 24 weeks post‐treatment (PT) and at appearance of IIT (TT).
Results Eleven patients developed IIT: three Hashimoto’s thyroiditis, one Graves’disease, one positive antithyroidal antibodies, one nonautoimmune hypothyroidism and five destructive thyroiditis. During antiviral treatment, an increase in CD8+ and in Tregs was observed in both groups. A decrease in CD3+, CD19+ and NKT lymphocyte subpopulations was also observed (all P |
| doi_str_mv | 10.1111/j.1365-2265.2011.04112.x |
| format | Article |
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Objective One of the side effects of interferon‐alpha (IFN‐α) therapy is interferon‐induced thyroiditis (IIT). The role of lymphocyte subpopulations in IIT remains to be defined. The aim of this study was to assess different peripheral blood lymphocyte subpopulations, mainly CD4+CD25+CD127low/‐FoxP3+ regulatory T cells (Tregs), in patients with chronic hepatitis C virus (HCV) infection who developed IIT.
Design, patients and methods From 120 patients with chronic HCV who started antiviral treatment, those who developed IIT (IIT patients) were selected and compared with patients who did not develop IIT (Co‐HCV). Peripheral blood mononuclear cells were obtained before treatment (BT), mid‐treatment (MT), end of treatment (ET), 24 weeks post‐treatment (PT) and at appearance of IIT (TT).
Results Eleven patients developed IIT: three Hashimoto’s thyroiditis, one Graves’disease, one positive antithyroidal antibodies, one nonautoimmune hypothyroidism and five destructive thyroiditis. During antiviral treatment, an increase in CD8+ and in Tregs was observed in both groups. A decrease in CD3+, CD19+ and NKT lymphocyte subpopulations was also observed (all P < 0·05). However, no changes were observed in the percentage of CD4+, CD3+γδ+ and iNKT lymphocytes, Th1/Th2 balance and Bcl2 expression on B cells when BT was compared with ET. At the appearance of IIT (TT), IIT patients had a higher Th1 response (CCR5+CCR7−) (P < 0·01) and a higher Tregs percentage (P < 0·05) than Co‐HCV.
Conclusions Our results point to the immunomodulatory effects of IFN‐α on different lymphocyte subpopulations and a possible role of Th1 response and Tregs in patients with HCV who developed IIT.</description><identifier>ISSN: 0300-0664</identifier><identifier>EISSN: 1365-2265</identifier><identifier>DOI: 10.1111/j.1365-2265.2011.04112.x</identifier><identifier>PMID: 21592168</identifier><identifier>CODEN: CLECAP</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adult ; Antibodies ; Antiviral Agents - adverse effects ; Antiviral Agents - therapeutic use ; Biological and medical sciences ; Endocrinopathies ; Female ; Flow Cytometry ; Fundamental and applied biological sciences. Psychology ; Hepatitis C virus ; Hepatitis C, Chronic - drug therapy ; Hepatitis C, Chronic - immunology ; Human viral diseases ; Humans ; Infectious diseases ; Interferons - adverse effects ; Interferons - therapeutic use ; Lymphocyte Subsets - immunology ; Male ; Medical sciences ; Middle Aged ; Non tumoral diseases. Target tissue resistance. Benign neoplasms ; Prospective Studies ; T-Lymphocytes, Regulatory - immunology ; Thyroid. Thyroid axis (diseases) ; Thyroiditis - chemically induced ; Thyroiditis - immunology ; Vertebrates: endocrinology ; Viral diseases ; Viral hepatitis</subject><ispartof>Clinical endocrinology (Oxford), 2011-10, Vol.75 (4), p.535-543</ispartof><rights>2011 Blackwell Publishing Ltd</rights><rights>2015 INIST-CNRS</rights><rights>2011 Blackwell Publishing Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4972-cdda0b925bbda9e2513a2399db845aeb1bbd23e3f9d837dceaa8c2b9463ca3f3</citedby><cites>FETCH-LOGICAL-c4972-cdda0b925bbda9e2513a2399db845aeb1bbd23e3f9d837dceaa8c2b9463ca3f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1365-2265.2011.04112.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1365-2265.2011.04112.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27923,27924,45573,45574</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24496754$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21592168$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Soldevila, Berta</creatorcontrib><creatorcontrib>Alonso, Núria</creatorcontrib><creatorcontrib>Martínez-Arconada, Maria J.</creatorcontrib><creatorcontrib>Granada, Maria L.</creatorcontrib><creatorcontrib>Baía, Diogo</creatorcontrib><creatorcontrib>Vallejos, Virginia</creatorcontrib><creatorcontrib>Fraile, Manuel</creatorcontrib><creatorcontrib>Morillas, Rosa M.</creatorcontrib><creatorcontrib>Planas, Ramon</creatorcontrib><creatorcontrib>Pujol-Borrell, Ricardo</creatorcontrib><creatorcontrib>Martínez-Cáceres, Eva M.</creatorcontrib><creatorcontrib>Sanmartí, Anna M.</creatorcontrib><title>A prospective study of lymphocyte subpopulations and regulatory T cells in patients with chronic hepatitis C virus infection developing interferon-induced thyroiditis</title><title>Clinical endocrinology (Oxford)</title><addtitle>Clin Endocrinol (Oxf)</addtitle><description>Summary
Objective One of the side effects of interferon‐alpha (IFN‐α) therapy is interferon‐induced thyroiditis (IIT). The role of lymphocyte subpopulations in IIT remains to be defined. The aim of this study was to assess different peripheral blood lymphocyte subpopulations, mainly CD4+CD25+CD127low/‐FoxP3+ regulatory T cells (Tregs), in patients with chronic hepatitis C virus (HCV) infection who developed IIT.
Design, patients and methods From 120 patients with chronic HCV who started antiviral treatment, those who developed IIT (IIT patients) were selected and compared with patients who did not develop IIT (Co‐HCV). Peripheral blood mononuclear cells were obtained before treatment (BT), mid‐treatment (MT), end of treatment (ET), 24 weeks post‐treatment (PT) and at appearance of IIT (TT).
Results Eleven patients developed IIT: three Hashimoto’s thyroiditis, one Graves’disease, one positive antithyroidal antibodies, one nonautoimmune hypothyroidism and five destructive thyroiditis. During antiviral treatment, an increase in CD8+ and in Tregs was observed in both groups. A decrease in CD3+, CD19+ and NKT lymphocyte subpopulations was also observed (all P < 0·05). However, no changes were observed in the percentage of CD4+, CD3+γδ+ and iNKT lymphocytes, Th1/Th2 balance and Bcl2 expression on B cells when BT was compared with ET. At the appearance of IIT (TT), IIT patients had a higher Th1 response (CCR5+CCR7−) (P < 0·01) and a higher Tregs percentage (P < 0·05) than Co‐HCV.
Conclusions Our results point to the immunomodulatory effects of IFN‐α on different lymphocyte subpopulations and a possible role of Th1 response and Tregs in patients with HCV who developed IIT.</description><subject>Adult</subject><subject>Antibodies</subject><subject>Antiviral Agents - adverse effects</subject><subject>Antiviral Agents - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Endocrinopathies</subject><subject>Female</subject><subject>Flow Cytometry</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hepatitis C virus</subject><subject>Hepatitis C, Chronic - drug therapy</subject><subject>Hepatitis C, Chronic - immunology</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Interferons - adverse effects</subject><subject>Interferons - therapeutic use</subject><subject>Lymphocyte Subsets - immunology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Non tumoral diseases. Target tissue resistance. Benign neoplasms</subject><subject>Prospective Studies</subject><subject>T-Lymphocytes, Regulatory - immunology</subject><subject>Thyroid. Thyroid axis (diseases)</subject><subject>Thyroiditis - chemically induced</subject><subject>Thyroiditis - immunology</subject><subject>Vertebrates: endocrinology</subject><subject>Viral diseases</subject><subject>Viral hepatitis</subject><issn>0300-0664</issn><issn>1365-2265</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkd-OEyEUxidG466rr2BIjNGbqfwZpnDhxabZXU2aVZMmekcYYLbU6TALTLfzQj6nYGtNvDByAxx-3zmc8xUFQHCG0nq3mSFS0xLjms4wRGgGK4TwbP-oOD89PC7OIYGwhHVdnRXPQthACCmD86fFGUaUY1Sz8-LHJRi8C4NR0e4MCHHUE3At6KbtsHZqiik2NoMbxk5G6_oAZK-BN3f57vwEVkCZrgvA9mBIhOljAA82roFae9dbBdYmx6MNYAF21o8ZbXM51wNtdqZzg-3vUjAa35qkKW2vR2U0iOvJO6uz9nnxpJVdMC-O-0Wxur5aLT6Uy083HxeXy1JVfI5LpbWEDce0abTkBlNEJCac64ZVVJoGpTgmhrRcMzLXykjJFG54VRMlSUsuijeHtGkm96MJUWxtyP3J3rgxCMZZ0qUhJvLtP0kEMWQVZiijr_5CN270fWpDIFpRxhHkdaLYgVLJjuBNKwZvt9JPKZXIpouNyN6K7K3Ipotfpot9kr48FhibrdEn4W-XE_D6CMigZNd62Ssb_nBVxes5rRL3_sA92M5M__0Bsbi6zaekLw96G6LZn_TSfxf1PM1NfL29EZRcL78R-Fl8IT8Bd0Xbwg</recordid><startdate>201110</startdate><enddate>201110</enddate><creator>Soldevila, Berta</creator><creator>Alonso, Núria</creator><creator>Martínez-Arconada, Maria J.</creator><creator>Granada, Maria L.</creator><creator>Baía, Diogo</creator><creator>Vallejos, Virginia</creator><creator>Fraile, Manuel</creator><creator>Morillas, Rosa M.</creator><creator>Planas, Ramon</creator><creator>Pujol-Borrell, Ricardo</creator><creator>Martínez-Cáceres, Eva M.</creator><creator>Sanmartí, Anna M.</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7T5</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>201110</creationdate><title>A prospective study of lymphocyte subpopulations and regulatory T cells in patients with chronic hepatitis C virus infection developing interferon-induced thyroiditis</title><author>Soldevila, Berta ; Alonso, Núria ; Martínez-Arconada, Maria J. ; Granada, Maria L. ; Baía, Diogo ; Vallejos, Virginia ; Fraile, Manuel ; Morillas, Rosa M. ; Planas, Ramon ; Pujol-Borrell, Ricardo ; Martínez-Cáceres, Eva M. ; Sanmartí, Anna M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4972-cdda0b925bbda9e2513a2399db845aeb1bbd23e3f9d837dceaa8c2b9463ca3f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adult</topic><topic>Antibodies</topic><topic>Antiviral Agents - adverse effects</topic><topic>Antiviral Agents - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Endocrinopathies</topic><topic>Female</topic><topic>Flow Cytometry</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hepatitis C virus</topic><topic>Hepatitis C, Chronic - drug therapy</topic><topic>Hepatitis C, Chronic - immunology</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Interferons - adverse effects</topic><topic>Interferons - therapeutic use</topic><topic>Lymphocyte Subsets - immunology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Non tumoral diseases. Target tissue resistance. Benign neoplasms</topic><topic>Prospective Studies</topic><topic>T-Lymphocytes, Regulatory - immunology</topic><topic>Thyroid. Thyroid axis (diseases)</topic><topic>Thyroiditis - chemically induced</topic><topic>Thyroiditis - immunology</topic><topic>Vertebrates: endocrinology</topic><topic>Viral diseases</topic><topic>Viral hepatitis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Soldevila, Berta</creatorcontrib><creatorcontrib>Alonso, Núria</creatorcontrib><creatorcontrib>Martínez-Arconada, Maria J.</creatorcontrib><creatorcontrib>Granada, Maria L.</creatorcontrib><creatorcontrib>Baía, Diogo</creatorcontrib><creatorcontrib>Vallejos, Virginia</creatorcontrib><creatorcontrib>Fraile, Manuel</creatorcontrib><creatorcontrib>Morillas, Rosa M.</creatorcontrib><creatorcontrib>Planas, Ramon</creatorcontrib><creatorcontrib>Pujol-Borrell, Ricardo</creatorcontrib><creatorcontrib>Martínez-Cáceres, Eva M.</creatorcontrib><creatorcontrib>Sanmartí, Anna M.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical endocrinology (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Soldevila, Berta</au><au>Alonso, Núria</au><au>Martínez-Arconada, Maria J.</au><au>Granada, Maria L.</au><au>Baía, Diogo</au><au>Vallejos, Virginia</au><au>Fraile, Manuel</au><au>Morillas, Rosa M.</au><au>Planas, Ramon</au><au>Pujol-Borrell, Ricardo</au><au>Martínez-Cáceres, Eva M.</au><au>Sanmartí, Anna M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A prospective study of lymphocyte subpopulations and regulatory T cells in patients with chronic hepatitis C virus infection developing interferon-induced thyroiditis</atitle><jtitle>Clinical endocrinology (Oxford)</jtitle><addtitle>Clin Endocrinol (Oxf)</addtitle><date>2011-10</date><risdate>2011</risdate><volume>75</volume><issue>4</issue><spage>535</spage><epage>543</epage><pages>535-543</pages><issn>0300-0664</issn><eissn>1365-2265</eissn><coden>CLECAP</coden><abstract>Summary
Objective One of the side effects of interferon‐alpha (IFN‐α) therapy is interferon‐induced thyroiditis (IIT). The role of lymphocyte subpopulations in IIT remains to be defined. The aim of this study was to assess different peripheral blood lymphocyte subpopulations, mainly CD4+CD25+CD127low/‐FoxP3+ regulatory T cells (Tregs), in patients with chronic hepatitis C virus (HCV) infection who developed IIT.
Design, patients and methods From 120 patients with chronic HCV who started antiviral treatment, those who developed IIT (IIT patients) were selected and compared with patients who did not develop IIT (Co‐HCV). Peripheral blood mononuclear cells were obtained before treatment (BT), mid‐treatment (MT), end of treatment (ET), 24 weeks post‐treatment (PT) and at appearance of IIT (TT).
Results Eleven patients developed IIT: three Hashimoto’s thyroiditis, one Graves’disease, one positive antithyroidal antibodies, one nonautoimmune hypothyroidism and five destructive thyroiditis. During antiviral treatment, an increase in CD8+ and in Tregs was observed in both groups. A decrease in CD3+, CD19+ and NKT lymphocyte subpopulations was also observed (all P < 0·05). However, no changes were observed in the percentage of CD4+, CD3+γδ+ and iNKT lymphocytes, Th1/Th2 balance and Bcl2 expression on B cells when BT was compared with ET. At the appearance of IIT (TT), IIT patients had a higher Th1 response (CCR5+CCR7−) (P < 0·01) and a higher Tregs percentage (P < 0·05) than Co‐HCV.
Conclusions Our results point to the immunomodulatory effects of IFN‐α on different lymphocyte subpopulations and a possible role of Th1 response and Tregs in patients with HCV who developed IIT.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>21592168</pmid><doi>10.1111/j.1365-2265.2011.04112.x</doi><tpages>9</tpages></addata></record> |
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| subjects | Adult Antibodies Antiviral Agents - adverse effects Antiviral Agents - therapeutic use Biological and medical sciences Endocrinopathies Female Flow Cytometry Fundamental and applied biological sciences. Psychology Hepatitis C virus Hepatitis C, Chronic - drug therapy Hepatitis C, Chronic - immunology Human viral diseases Humans Infectious diseases Interferons - adverse effects Interferons - therapeutic use Lymphocyte Subsets - immunology Male Medical sciences Middle Aged Non tumoral diseases. Target tissue resistance. Benign neoplasms Prospective Studies T-Lymphocytes, Regulatory - immunology Thyroid. Thyroid axis (diseases) Thyroiditis - chemically induced Thyroiditis - immunology Vertebrates: endocrinology Viral diseases Viral hepatitis |
| title | A prospective study of lymphocyte subpopulations and regulatory T cells in patients with chronic hepatitis C virus infection developing interferon-induced thyroiditis |
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