Cyclophilin A promotes human hepatocellular carcinoma cell metastasis via regulation of MMP3 and MMP9

Cyclophilin A (CypA) is a member of peptidyl prolyl isomerases (PPIases), which catalyze the cis / trans isomerization of prolyl peptide bonds on the NH-terminal side of Pro residues in peptide chains. Altered expression of CypA has been reported in hepatocellular carcinoma (HCC), but the biological...

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Veröffentlicht in:	Molecular and cellular biochemistry 2011-11, Vol.357 (1-2), p.387-395
Hauptverfasser:	Zhang, Mingjun, Dai, Chun, Zhu, Hengrui, Chen, Shuai, Wu, Yanhua, Li, Qiang, Zeng, Xianzhuo, Wang, Wenzhang, Zuo, Jie, Zhou, Mei, Xia, Zongjun, Ji, Guoqing, Saiyin, Hexige, Qin, Lunxiu, Yu, Long
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biochemistry Biomedical and Life Sciences Cancer Carcinoma, Hepatocellular - genetics Carcinoma, Hepatocellular - metabolism Carcinoma, Hepatocellular - pathology Cardiology Cell Adhesion - genetics Cell Line, Tumor Cell Proliferation Cells Cyclophilin A - genetics Cyclophilin A - metabolism DNA microarrays Gene Expression Regulation, Neoplastic Hepatoma Humans Isomerization Life Sciences Liver Neoplasms - genetics Liver Neoplasms - metabolism Liver Neoplasms - pathology Matrix Matrix Metalloproteinase 3 - genetics Matrix Metalloproteinase 3 - metabolism Matrix Metalloproteinase 9 - genetics Matrix Metalloproteinase 9 - metabolism Medical Biochemistry Metastasis Mice Mice, Nude Microarray Analysis Neoplasm Invasiveness - genetics Neoplasm Metastasis Oncology Peptides
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