Formulation and evaluation of mucoadhesive glipizide films
Glipizide is mainly absorbed in the proximal areas of the gastrointestinal tract. The purpose of this study was formulation and evaluation of mucoadhesive films to prolong the stay of drug in its absorption area. Glipizide was formulated in a mucoadhesive film that could be retained in the stomach f...
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| Veröffentlicht in: | Acta pharmaceutica (Zagreb, Croatia) Croatia), 2011-06, Vol.61 (2), p.203-216 |
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| creator | Rajput, Ganesh Majmudar, Falguni Patel, Jayvadan |
| description | Glipizide is mainly absorbed in the proximal areas of the gastrointestinal tract. The purpose of this study was formulation and evaluation of mucoadhesive films to prolong the stay of drug in its absorption area. Glipizide was formulated in a mucoadhesive film that could be retained in the stomach for prolonged intervals. Polymeric films were designed with various compositions of hydroxypropyl cellulose and polyethylene glycol 400 (PEG 400). Properties of the mucoadhesive film such as tensile strength, percentage elongation, swelling index, moisture content, pH and viscosity of polymeric dispersion, film thickness, content uniformity and mucoadhesion in a simulated gastric environment were characterized. In addition, percentage drug retained in stomach mucosa was estimated using a simulated dynamic stomach system as a function of time. Increase in hydroxypropyl cellulose concentration resulted in a higher tensile strength and elongation at break, while increase in concentration of PEG 400 was reflected in a decrease in tensile strength and increase of elongation at break. Glipizide/hydroxypropyl cellulose/PEG 400 (2.5:1:0.5) (GF5) was found to be the optimal composition for a novel mucoadhesive stomach formulation that showed good peelability, relatively high swelling index, moderate tensile strength, and stayed on rat stomach mucosa up to 8 h. In vivo testing of the mucoadhesive films with glipizide demonstrated a potential hypoglycemic effect.
Glipizid se pretežno apsorbira u proksimalnom dijelu gastrointestinalnog trakta. Cilj rada je priprava i evaluacija mukoadhezivnih filmova s kojima bi se produljilo zadržavanje lijeka u predjelu apsorpcije. Pripravljeni su mukoadhezivni filmovi glipizida koji se produljeno zadržavaju u želucu. Polimerni filmovi sadržavali su različite količine hidroksipropil celuloze i polietilen glikola 400 (PEG 400). Evaluirana su sljedeća svojstva mukoadhezivnih filmova: čvrstoća, postotak elongacije, indeks bubrenja, sadržaj vlage, pH i viskoznost polimerne disperzije, debljina filma, koncentracija lijeka, jednolikost i mukoadhezivnost u simuliranom želučanom soku. Na dinamičkom modelu želuca određ ivan je i postotak lijeka koji se zadržava u sluznici želuca u ovisnosti o vremenu. Poveć anjem koncentracije hidroksipropil celuloze povećavaju se čvrstoća i elongacija, dok se povećanje koncentracije PEG 400 reflektira na smanjenje čvrstoće i povećanje elongacije kod loma. Omjer glipizid/hidroksipropil celuloza/PEG 400 (2,5:1:0,5) |
| doi_str_mv | 10.2478/v10007-011-0017-3 |
| format | Article |
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Glipizid se pretežno apsorbira u proksimalnom dijelu gastrointestinalnog trakta. Cilj rada je priprava i evaluacija mukoadhezivnih filmova s kojima bi se produljilo zadržavanje lijeka u predjelu apsorpcije. Pripravljeni su mukoadhezivni filmovi glipizida koji se produljeno zadržavaju u želucu. Polimerni filmovi sadržavali su različite količine hidroksipropil celuloze i polietilen glikola 400 (PEG 400). Evaluirana su sljedeća svojstva mukoadhezivnih filmova: čvrstoća, postotak elongacije, indeks bubrenja, sadržaj vlage, pH i viskoznost polimerne disperzije, debljina filma, koncentracija lijeka, jednolikost i mukoadhezivnost u simuliranom želučanom soku. Na dinamičkom modelu želuca određ ivan je i postotak lijeka koji se zadržava u sluznici želuca u ovisnosti o vremenu. Poveć anjem koncentracije hidroksipropil celuloze povećavaju se čvrstoća i elongacija, dok se povećanje koncentracije PEG 400 reflektira na smanjenje čvrstoće i povećanje elongacije kod loma. Omjer glipizid/hidroksipropil celuloza/PEG 400 (2,5:1:0,5) (GF5) bio je optimalan za pripravu mukoadhezivnih formulacija, s dobrom kalavošću, relativno visokim indeksom bubrenja, umjerenom čvrstoćom te zadržavanjem u sluznici želuca štakora do 8 h. U in vivo testiranjima mukoadhesivni filmovi s glipizidom pokazali su potencijalni hipoglikemijski učinak.</description><identifier>ISSN: 1330-0075</identifier><identifier>EISSN: 1846-9558</identifier><identifier>DOI: 10.2478/v10007-011-0017-3</identifier><identifier>PMID: 21684847</identifier><language>eng</language><publisher>Croatia: Versita</publisher><subject>Adhesiveness ; Animals ; Blood Glucose - analysis ; Cellulose - analogs & derivatives ; Cellulose - chemistry ; Chemical Phenomena ; Delayed-Action Preparations ; desirability function ; Drug Carriers - administration & dosage ; Drug Carriers - chemistry ; Drug Carriers - pharmacology ; Drug Compounding ; Excipients - chemistry ; factorial design ; faktorijalno dizajniranje ; Female ; funkcija poželjnosti ; Gastric Mucosa - metabolism ; glipizid ; glipizide ; Glipizide - administration & dosage ; Glipizide - chemistry ; Glipizide - pharmacology ; hipoglikemijski učinak ; Hydrogen-Ion Concentration ; Hypoglycemic Agents - administration & dosage ; Hypoglycemic Agents - chemistry ; Hypoglycemic Agents - pharmacology ; hypoglycemic effect ; In Vitro Techniques ; Male ; Mechanical Phenomena ; mucoadhesive film ; mukoadhezivni film ; Polyethylene Glycols - chemistry ; Polymers - chemistry ; Rats ; Rats, Wistar ; Specific Pathogen-Free Organisms ; Water - analysis</subject><ispartof>Acta pharmaceutica (Zagreb, Croatia), 2011-06, Vol.61 (2), p.203-216</ispartof><rights>Copyright Versita Jun 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c409t-5d926e23efc1d87471567ae097e85b0e47869594381668ff007c8228c826554e3</citedby><cites>FETCH-LOGICAL-c409t-5d926e23efc1d87471567ae097e85b0e47869594381668ff007c8228c826554e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,860,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21684847$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rajput, Ganesh</creatorcontrib><creatorcontrib>Majmudar, Falguni</creatorcontrib><creatorcontrib>Patel, Jayvadan</creatorcontrib><title>Formulation and evaluation of mucoadhesive glipizide films</title><title>Acta pharmaceutica (Zagreb, Croatia)</title><addtitle>Acta Pharm</addtitle><description>Glipizide is mainly absorbed in the proximal areas of the gastrointestinal tract. The purpose of this study was formulation and evaluation of mucoadhesive films to prolong the stay of drug in its absorption area. Glipizide was formulated in a mucoadhesive film that could be retained in the stomach for prolonged intervals. Polymeric films were designed with various compositions of hydroxypropyl cellulose and polyethylene glycol 400 (PEG 400). Properties of the mucoadhesive film such as tensile strength, percentage elongation, swelling index, moisture content, pH and viscosity of polymeric dispersion, film thickness, content uniformity and mucoadhesion in a simulated gastric environment were characterized. In addition, percentage drug retained in stomach mucosa was estimated using a simulated dynamic stomach system as a function of time. Increase in hydroxypropyl cellulose concentration resulted in a higher tensile strength and elongation at break, while increase in concentration of PEG 400 was reflected in a decrease in tensile strength and increase of elongation at break. Glipizide/hydroxypropyl cellulose/PEG 400 (2.5:1:0.5) (GF5) was found to be the optimal composition for a novel mucoadhesive stomach formulation that showed good peelability, relatively high swelling index, moderate tensile strength, and stayed on rat stomach mucosa up to 8 h. In vivo testing of the mucoadhesive films with glipizide demonstrated a potential hypoglycemic effect.
Glipizid se pretežno apsorbira u proksimalnom dijelu gastrointestinalnog trakta. Cilj rada je priprava i evaluacija mukoadhezivnih filmova s kojima bi se produljilo zadržavanje lijeka u predjelu apsorpcije. Pripravljeni su mukoadhezivni filmovi glipizida koji se produljeno zadržavaju u želucu. Polimerni filmovi sadržavali su različite količine hidroksipropil celuloze i polietilen glikola 400 (PEG 400). Evaluirana su sljedeća svojstva mukoadhezivnih filmova: čvrstoća, postotak elongacije, indeks bubrenja, sadržaj vlage, pH i viskoznost polimerne disperzije, debljina filma, koncentracija lijeka, jednolikost i mukoadhezivnost u simuliranom želučanom soku. Na dinamičkom modelu želuca određ ivan je i postotak lijeka koji se zadržava u sluznici želuca u ovisnosti o vremenu. Poveć anjem koncentracije hidroksipropil celuloze povećavaju se čvrstoća i elongacija, dok se povećanje koncentracije PEG 400 reflektira na smanjenje čvrstoće i povećanje elongacije kod loma. Omjer glipizid/hidroksipropil celuloza/PEG 400 (2,5:1:0,5) (GF5) bio je optimalan za pripravu mukoadhezivnih formulacija, s dobrom kalavošću, relativno visokim indeksom bubrenja, umjerenom čvrstoćom te zadržavanjem u sluznici želuca štakora do 8 h. U in vivo testiranjima mukoadhesivni filmovi s glipizidom pokazali su potencijalni hipoglikemijski učinak.</description><subject>Adhesiveness</subject><subject>Animals</subject><subject>Blood Glucose - analysis</subject><subject>Cellulose - analogs & derivatives</subject><subject>Cellulose - chemistry</subject><subject>Chemical Phenomena</subject><subject>Delayed-Action Preparations</subject><subject>desirability function</subject><subject>Drug Carriers - administration & dosage</subject><subject>Drug Carriers - chemistry</subject><subject>Drug Carriers - pharmacology</subject><subject>Drug Compounding</subject><subject>Excipients - chemistry</subject><subject>factorial design</subject><subject>faktorijalno dizajniranje</subject><subject>Female</subject><subject>funkcija poželjnosti</subject><subject>Gastric Mucosa - metabolism</subject><subject>glipizid</subject><subject>glipizide</subject><subject>Glipizide - administration & dosage</subject><subject>Glipizide - chemistry</subject><subject>Glipizide - pharmacology</subject><subject>hipoglikemijski učinak</subject><subject>Hydrogen-Ion Concentration</subject><subject>Hypoglycemic Agents - administration & dosage</subject><subject>Hypoglycemic Agents - chemistry</subject><subject>Hypoglycemic Agents - pharmacology</subject><subject>hypoglycemic effect</subject><subject>In Vitro Techniques</subject><subject>Male</subject><subject>Mechanical Phenomena</subject><subject>mucoadhesive film</subject><subject>mukoadhezivni film</subject><subject>Polyethylene Glycols - chemistry</subject><subject>Polymers - chemistry</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Specific Pathogen-Free Organisms</subject><subject>Water - analysis</subject><issn>1330-0075</issn><issn>1846-9558</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNpdkE1LxDAQhoMofv8AL1Lw4Kk6-U68-a2wIsIqewuxnWq03a7NdlF_vZGqBy9JhnnmZfIQskPhgAltDhcUAHQOlOYAVOd8iaxTI1RupTTL6c05pI6Wa2QjxhcAobVhq2SNUWWEEXqdHF20XdPXfh7aaeanZYYLX_dD2VZZ0xetL58xhgVmT3WYhc9QYlaFuolbZKXydcTtn3uT3F-cj0-v8tHt5fXp8SgvBNh5LkvLFDKOVUFLo4WmUmmPYDUa-QiYPqKstIIbqpSpqrRvYRgz6VBSCuSbZH_InXXtW49x7poQC6xrP8W2j85YI0EzBonc-0e-tH03Tcs5yqlNqWBpouhAFV0bY4eVm3Wh8d2Ho-C-vbrBq0te3bdXx9PM7k9y_9hg-TfxKzIB-QCEOMf3v77vXp3SXEt3NxZO30wmI_tw5k74F3b5f-U</recordid><startdate>20110601</startdate><enddate>20110601</enddate><creator>Rajput, Ganesh</creator><creator>Majmudar, Falguni</creator><creator>Patel, Jayvadan</creator><general>Versita</general><general>De Gruyter Poland</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BYOGL</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20110601</creationdate><title>Formulation and evaluation of mucoadhesive glipizide films</title><author>Rajput, Ganesh ; Majmudar, Falguni ; Patel, Jayvadan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c409t-5d926e23efc1d87471567ae097e85b0e47869594381668ff007c8228c826554e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adhesiveness</topic><topic>Animals</topic><topic>Blood Glucose - analysis</topic><topic>Cellulose - analogs & derivatives</topic><topic>Cellulose - chemistry</topic><topic>Chemical Phenomena</topic><topic>Delayed-Action Preparations</topic><topic>desirability function</topic><topic>Drug Carriers - administration & dosage</topic><topic>Drug Carriers - chemistry</topic><topic>Drug Carriers - pharmacology</topic><topic>Drug Compounding</topic><topic>Excipients - chemistry</topic><topic>factorial design</topic><topic>faktorijalno dizajniranje</topic><topic>Female</topic><topic>funkcija poželjnosti</topic><topic>Gastric Mucosa - metabolism</topic><topic>glipizid</topic><topic>glipizide</topic><topic>Glipizide - administration & dosage</topic><topic>Glipizide - chemistry</topic><topic>Glipizide - pharmacology</topic><topic>hipoglikemijski učinak</topic><topic>Hydrogen-Ion Concentration</topic><topic>Hypoglycemic Agents - administration & dosage</topic><topic>Hypoglycemic Agents - chemistry</topic><topic>Hypoglycemic Agents - pharmacology</topic><topic>hypoglycemic effect</topic><topic>In Vitro Techniques</topic><topic>Male</topic><topic>Mechanical Phenomena</topic><topic>mucoadhesive film</topic><topic>mukoadhezivni film</topic><topic>Polyethylene Glycols - chemistry</topic><topic>Polymers - chemistry</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Specific Pathogen-Free Organisms</topic><topic>Water - analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rajput, Ganesh</creatorcontrib><creatorcontrib>Majmudar, Falguni</creatorcontrib><creatorcontrib>Patel, Jayvadan</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>East Europe, Central Europe Database</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Acta pharmaceutica (Zagreb, Croatia)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rajput, Ganesh</au><au>Majmudar, Falguni</au><au>Patel, Jayvadan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Formulation and evaluation of mucoadhesive glipizide films</atitle><jtitle>Acta pharmaceutica (Zagreb, Croatia)</jtitle><addtitle>Acta Pharm</addtitle><date>2011-06-01</date><risdate>2011</risdate><volume>61</volume><issue>2</issue><spage>203</spage><epage>216</epage><pages>203-216</pages><issn>1330-0075</issn><eissn>1846-9558</eissn><abstract>Glipizide is mainly absorbed in the proximal areas of the gastrointestinal tract. The purpose of this study was formulation and evaluation of mucoadhesive films to prolong the stay of drug in its absorption area. Glipizide was formulated in a mucoadhesive film that could be retained in the stomach for prolonged intervals. Polymeric films were designed with various compositions of hydroxypropyl cellulose and polyethylene glycol 400 (PEG 400). Properties of the mucoadhesive film such as tensile strength, percentage elongation, swelling index, moisture content, pH and viscosity of polymeric dispersion, film thickness, content uniformity and mucoadhesion in a simulated gastric environment were characterized. In addition, percentage drug retained in stomach mucosa was estimated using a simulated dynamic stomach system as a function of time. Increase in hydroxypropyl cellulose concentration resulted in a higher tensile strength and elongation at break, while increase in concentration of PEG 400 was reflected in a decrease in tensile strength and increase of elongation at break. Glipizide/hydroxypropyl cellulose/PEG 400 (2.5:1:0.5) (GF5) was found to be the optimal composition for a novel mucoadhesive stomach formulation that showed good peelability, relatively high swelling index, moderate tensile strength, and stayed on rat stomach mucosa up to 8 h. In vivo testing of the mucoadhesive films with glipizide demonstrated a potential hypoglycemic effect.
Glipizid se pretežno apsorbira u proksimalnom dijelu gastrointestinalnog trakta. Cilj rada je priprava i evaluacija mukoadhezivnih filmova s kojima bi se produljilo zadržavanje lijeka u predjelu apsorpcije. Pripravljeni su mukoadhezivni filmovi glipizida koji se produljeno zadržavaju u želucu. Polimerni filmovi sadržavali su različite količine hidroksipropil celuloze i polietilen glikola 400 (PEG 400). Evaluirana su sljedeća svojstva mukoadhezivnih filmova: čvrstoća, postotak elongacije, indeks bubrenja, sadržaj vlage, pH i viskoznost polimerne disperzije, debljina filma, koncentracija lijeka, jednolikost i mukoadhezivnost u simuliranom želučanom soku. Na dinamičkom modelu želuca određ ivan je i postotak lijeka koji se zadržava u sluznici želuca u ovisnosti o vremenu. Poveć anjem koncentracije hidroksipropil celuloze povećavaju se čvrstoća i elongacija, dok se povećanje koncentracije PEG 400 reflektira na smanjenje čvrstoće i povećanje elongacije kod loma. Omjer glipizid/hidroksipropil celuloza/PEG 400 (2,5:1:0,5) (GF5) bio je optimalan za pripravu mukoadhezivnih formulacija, s dobrom kalavošću, relativno visokim indeksom bubrenja, umjerenom čvrstoćom te zadržavanjem u sluznici želuca štakora do 8 h. U in vivo testiranjima mukoadhesivni filmovi s glipizidom pokazali su potencijalni hipoglikemijski učinak.</abstract><cop>Croatia</cop><pub>Versita</pub><pmid>21684847</pmid><doi>10.2478/v10007-011-0017-3</doi><tpages>14</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Acta pharmaceutica (Zagreb, Croatia), 2011-06, Vol.61 (2), p.203-216 |
| issn | 1330-0075 1846-9558 |
| language | eng |
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| source | MEDLINE; De Gruyter Open Access Journals; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals |
| subjects | Adhesiveness Animals Blood Glucose - analysis Cellulose - analogs & derivatives Cellulose - chemistry Chemical Phenomena Delayed-Action Preparations desirability function Drug Carriers - administration & dosage Drug Carriers - chemistry Drug Carriers - pharmacology Drug Compounding Excipients - chemistry factorial design faktorijalno dizajniranje Female funkcija poželjnosti Gastric Mucosa - metabolism glipizid glipizide Glipizide - administration & dosage Glipizide - chemistry Glipizide - pharmacology hipoglikemijski učinak Hydrogen-Ion Concentration Hypoglycemic Agents - administration & dosage Hypoglycemic Agents - chemistry Hypoglycemic Agents - pharmacology hypoglycemic effect In Vitro Techniques Male Mechanical Phenomena mucoadhesive film mukoadhezivni film Polyethylene Glycols - chemistry Polymers - chemistry Rats Rats, Wistar Specific Pathogen-Free Organisms Water - analysis |
| title | Formulation and evaluation of mucoadhesive glipizide films |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-26T11%3A28%3A26IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Formulation%20and%20evaluation%20of%20mucoadhesive%20glipizide%20films&rft.jtitle=Acta%20pharmaceutica%20(Zagreb,%20Croatia)&rft.au=Rajput,%20Ganesh&rft.date=2011-06-01&rft.volume=61&rft.issue=2&rft.spage=203&rft.epage=216&rft.pages=203-216&rft.issn=1330-0075&rft.eissn=1846-9558&rft_id=info:doi/10.2478/v10007-011-0017-3&rft_dat=%3Cproquest_cross%3E2928266351%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1319822091&rft_id=info:pmid/21684847&rfr_iscdi=true |