Transdermal estrogen therapy effects on fibrinogen levels in women with a past history of venous thromboembolism: a pilot study
To evaluate thromboelastographic parameters and fibrinogen levels in women treated with transdermal 17beta estradiol. 29 menopausal women with a history of venous thromboembolic disease were included. Nine patients composed the treatment (HT) group and 20 the control group. Coagulation was assessed...
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| Veröffentlicht in: | Clinical and experimental obstetrics & gynecology 2011, Vol.38 (3), p.232-235 |
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| container_title | Clinical and experimental obstetrics & gynecology |
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| creator | Margarido, P F R Bagnoli, V R Maggio da Fonseca, A Maciel, G A R Soares, Jr, J M D'Amico, E A Baracat, E C |
| description | To evaluate thromboelastographic parameters and fibrinogen levels in women treated with transdermal 17beta estradiol.
29 menopausal women with a history of venous thromboembolic disease were included. Nine patients composed the treatment (HT) group and 20 the control group. Coagulation was assessed by thromboelastography in samples of whole blood and platelet-poor plasma (PPP). The following thromboelastographic variables were measured: time for initial coagulation (R), blood clotting speed (K and the alpha angle), clot tensile strength (MA and G), global index of coagulation (CI) and fibrinolysis (LY30) and fibrinogen levels.
There were no differences in the other parameters comparing both groups. Fibrinogen levels showed a 13.77 +/- 19.94% reduction in the HT group and a 5.51 +/- 8.09% increase in the control group after 6 months.
Our data suggested that transdermal estrogen may not increase blood coagulability, but that it reduces fibrinogen levels in HT women. |
| format | Article |
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29 menopausal women with a history of venous thromboembolic disease were included. Nine patients composed the treatment (HT) group and 20 the control group. Coagulation was assessed by thromboelastography in samples of whole blood and platelet-poor plasma (PPP). The following thromboelastographic variables were measured: time for initial coagulation (R), blood clotting speed (K and the alpha angle), clot tensile strength (MA and G), global index of coagulation (CI) and fibrinolysis (LY30) and fibrinogen levels.
There were no differences in the other parameters comparing both groups. Fibrinogen levels showed a 13.77 +/- 19.94% reduction in the HT group and a 5.51 +/- 8.09% increase in the control group after 6 months.
Our data suggested that transdermal estrogen may not increase blood coagulability, but that it reduces fibrinogen levels in HT women.</description><identifier>ISSN: 0390-6663</identifier><identifier>PMID: 21995153</identifier><language>eng</language><publisher>Canada</publisher><subject>Administration, Cutaneous ; Adult ; Analysis of Variance ; Estradiol - administration & dosage ; Estrogen Replacement Therapy ; Estrogens - administration & dosage ; Female ; Fibrinogen - analysis ; Humans ; Middle Aged ; Pilot Projects ; Thrombelastography ; Venous Thromboembolism - blood</subject><ispartof>Clinical and experimental obstetrics & gynecology, 2011, Vol.38 (3), p.232-235</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,782,786,4026</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21995153$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Margarido, P F R</creatorcontrib><creatorcontrib>Bagnoli, V R</creatorcontrib><creatorcontrib>Maggio da Fonseca, A</creatorcontrib><creatorcontrib>Maciel, G A R</creatorcontrib><creatorcontrib>Soares, Jr, J M</creatorcontrib><creatorcontrib>D'Amico, E A</creatorcontrib><creatorcontrib>Baracat, E C</creatorcontrib><title>Transdermal estrogen therapy effects on fibrinogen levels in women with a past history of venous thromboembolism: a pilot study</title><title>Clinical and experimental obstetrics & gynecology</title><addtitle>Clin Exp Obstet Gynecol</addtitle><description>To evaluate thromboelastographic parameters and fibrinogen levels in women treated with transdermal 17beta estradiol.
29 menopausal women with a history of venous thromboembolic disease were included. Nine patients composed the treatment (HT) group and 20 the control group. Coagulation was assessed by thromboelastography in samples of whole blood and platelet-poor plasma (PPP). The following thromboelastographic variables were measured: time for initial coagulation (R), blood clotting speed (K and the alpha angle), clot tensile strength (MA and G), global index of coagulation (CI) and fibrinolysis (LY30) and fibrinogen levels.
There were no differences in the other parameters comparing both groups. Fibrinogen levels showed a 13.77 +/- 19.94% reduction in the HT group and a 5.51 +/- 8.09% increase in the control group after 6 months.
Our data suggested that transdermal estrogen may not increase blood coagulability, but that it reduces fibrinogen levels in HT women.</description><subject>Administration, Cutaneous</subject><subject>Adult</subject><subject>Analysis of Variance</subject><subject>Estradiol - administration & dosage</subject><subject>Estrogen Replacement Therapy</subject><subject>Estrogens - administration & dosage</subject><subject>Female</subject><subject>Fibrinogen - analysis</subject><subject>Humans</subject><subject>Middle Aged</subject><subject>Pilot Projects</subject><subject>Thrombelastography</subject><subject>Venous Thromboembolism - blood</subject><issn>0390-6663</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1kE1LxDAQhntQ3HX1L0hungpJk6aJN1n8ggUv67mk7cRG0qYm6S49-deNug7MF_PwMjNn2RpTiXPOOV1llyF8YMxYxclFtiqIlCUp6Tr72ns1hg78oCyCEL17hxHFHryaFgRaQxsDciPSpvFm_J1aOIANyIzo6IbUH03skUKTChH1JkTnF-Q0OsDo5pC0vBsaB8mtCcPdD2msiyjEuVuusnOtbIDrU95kb48P--1zvnt9etne7_KpIDjmssFCNkKXHXDJmkqkWlaVKjFLkSjcaaEEYawVZUGqZAJXTGBoKW8kLegmu_3Tnbz7nNOh9WBCC9aqEdKWtZCixDyBibw5kXMzQFdP3gzKL_X_z-g3an5pMg</recordid><startdate>2011</startdate><enddate>2011</enddate><creator>Margarido, P F R</creator><creator>Bagnoli, V R</creator><creator>Maggio da Fonseca, A</creator><creator>Maciel, G A R</creator><creator>Soares, Jr, J M</creator><creator>D'Amico, E A</creator><creator>Baracat, E C</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>2011</creationdate><title>Transdermal estrogen therapy effects on fibrinogen levels in women with a past history of venous thromboembolism: a pilot study</title><author>Margarido, P F R ; Bagnoli, V R ; Maggio da Fonseca, A ; Maciel, G A R ; Soares, Jr, J M ; D'Amico, E A ; Baracat, E C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p210t-9b089b8f5de694b78b8f977a50477a1a0df8a8144c85217777807480ec36b9323</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Administration, Cutaneous</topic><topic>Adult</topic><topic>Analysis of Variance</topic><topic>Estradiol - administration & dosage</topic><topic>Estrogen Replacement Therapy</topic><topic>Estrogens - administration & dosage</topic><topic>Female</topic><topic>Fibrinogen - analysis</topic><topic>Humans</topic><topic>Middle Aged</topic><topic>Pilot Projects</topic><topic>Thrombelastography</topic><topic>Venous Thromboembolism - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Margarido, P F R</creatorcontrib><creatorcontrib>Bagnoli, V R</creatorcontrib><creatorcontrib>Maggio da Fonseca, A</creatorcontrib><creatorcontrib>Maciel, G A R</creatorcontrib><creatorcontrib>Soares, Jr, J M</creatorcontrib><creatorcontrib>D'Amico, E A</creatorcontrib><creatorcontrib>Baracat, E C</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical and experimental obstetrics & gynecology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Margarido, P F R</au><au>Bagnoli, V R</au><au>Maggio da Fonseca, A</au><au>Maciel, G A R</au><au>Soares, Jr, J M</au><au>D'Amico, E A</au><au>Baracat, E C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Transdermal estrogen therapy effects on fibrinogen levels in women with a past history of venous thromboembolism: a pilot study</atitle><jtitle>Clinical and experimental obstetrics & gynecology</jtitle><addtitle>Clin Exp Obstet Gynecol</addtitle><date>2011</date><risdate>2011</risdate><volume>38</volume><issue>3</issue><spage>232</spage><epage>235</epage><pages>232-235</pages><issn>0390-6663</issn><abstract>To evaluate thromboelastographic parameters and fibrinogen levels in women treated with transdermal 17beta estradiol.
29 menopausal women with a history of venous thromboembolic disease were included. Nine patients composed the treatment (HT) group and 20 the control group. Coagulation was assessed by thromboelastography in samples of whole blood and platelet-poor plasma (PPP). The following thromboelastographic variables were measured: time for initial coagulation (R), blood clotting speed (K and the alpha angle), clot tensile strength (MA and G), global index of coagulation (CI) and fibrinolysis (LY30) and fibrinogen levels.
There were no differences in the other parameters comparing both groups. Fibrinogen levels showed a 13.77 +/- 19.94% reduction in the HT group and a 5.51 +/- 8.09% increase in the control group after 6 months.
Our data suggested that transdermal estrogen may not increase blood coagulability, but that it reduces fibrinogen levels in HT women.</abstract><cop>Canada</cop><pmid>21995153</pmid><tpages>4</tpages></addata></record> |
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| ispartof | Clinical and experimental obstetrics & gynecology, 2011, Vol.38 (3), p.232-235 |
| issn | 0390-6663 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Administration, Cutaneous Adult Analysis of Variance Estradiol - administration & dosage Estrogen Replacement Therapy Estrogens - administration & dosage Female Fibrinogen - analysis Humans Middle Aged Pilot Projects Thrombelastography Venous Thromboembolism - blood |
| title | Transdermal estrogen therapy effects on fibrinogen levels in women with a past history of venous thromboembolism: a pilot study |
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