The role of oral contraception use in the occurrence of breast cancer. A retrospective study of 405 patients

The investigation of potential predisposing factors of breast cancer, a disease accounting for almost one-third of malignancies in women, is necessary in order to reduce the incidence. We interviewed 405 female patients who had been diagnosed with breast cancer and who also reported having used oral contraceptive pills before. They were categorized into two groups (group A < 7 years OC use and group B > 7 years OC use). Statistical analysis revealed a small (p < 0.02) but significant increased risk of the disease to BRCA mutation carriers, as well as to the women with a significant medical or family history of breast, ovarian or colon cancer who had also previously used oral contraceptive pills for more than seven years. Breast cancer seems to be positively dependent on prolonged oral contraceptive use. More research is needed to establish the hypothesis that the human genome is vulnerable to oral contraceptives.