Urinary Tract Infections in the Early Posttransplant Period After Liver Transplantation: Etiologic Agents and Their Susceptibility
Abstract Background We performed an analysis of etiologic agents for urinary tract infections in the early posttransplant period after orthotopic liver transplantation (OLT) in adult recipients. Patients and Methods The study covered the first 4 weeks after OLT of 190 patients from September 2001 to...
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| creator | Kawecki, D Pacholczyk, M Łagiewska, B Adadyński, L Lisik, W Sawicka-Grzelak, A Durlik, M Paczek, L Chmura, A Mlynarczyk, G Rowinski, W Luczak, M |
| description | Abstract Background We performed an analysis of etiologic agents for urinary tract infections in the early posttransplant period after orthotopic liver transplantation (OLT) in adult recipients. Patients and Methods The study covered the first 4 weeks after OLT of 190 patients from September 2001 to the end of 2007. Immunosuppression consisted of steroids and tacrolimus. Antimicrobial prophylaxis was piperacillin/tazobactam, fluconazole, and SBD. Urine samples were cultured to identify microorganisms in accord with standard microbiological procedures and to test susceptibility using Clinical Laboratory and Standards Institute guidelines. Results Urine specimens ( n = 539) examined from 185 recipients (97.4%) showed 210 microbial strains. The most common were Gram-negative ( n = 131; 62.4%) with predominance of Escherichia coli (28.2%), Enterobacter cloacae (19.1%), and Acinetobacter baumannii (11.4%). Extended-spectrum β- lactamases (ESBL(+)) strains were isolated in 38.5% of cases. Gram-positive bacteria comprised 28.6% ( n = 60): The most common strains were enterococci (85% including HLAR 80.4% and VRE 17.6%] and staphylococci 11.8% [MRSA/MRCNS; 100%]. There were 19 (9%) fungal strains. Conclusions In general, the identification in urine samples of multi-drug–resistant bacterial and fungal strains in patients after OLT such as ESBL(+) 38.5%; HLAR 80.4%; VRE 17.6%; and MRSA/MRCNS 100% requires better infection control. |
| doi_str_mv | 10.1016/j.transproceed.2011.09.003 |
| format | Article |
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Patients and Methods The study covered the first 4 weeks after OLT of 190 patients from September 2001 to the end of 2007. Immunosuppression consisted of steroids and tacrolimus. Antimicrobial prophylaxis was piperacillin/tazobactam, fluconazole, and SBD. Urine samples were cultured to identify microorganisms in accord with standard microbiological procedures and to test susceptibility using Clinical Laboratory and Standards Institute guidelines. Results Urine specimens ( n = 539) examined from 185 recipients (97.4%) showed 210 microbial strains. The most common were Gram-negative ( n = 131; 62.4%) with predominance of Escherichia coli (28.2%), Enterobacter cloacae (19.1%), and Acinetobacter baumannii (11.4%). Extended-spectrum β- lactamases (ESBL(+)) strains were isolated in 38.5% of cases. Gram-positive bacteria comprised 28.6% ( n = 60): The most common strains were enterococci (85% including HLAR 80.4% and VRE 17.6%] and staphylococci 11.8% [MRSA/MRCNS; 100%]. There were 19 (9%) fungal strains. Conclusions In general, the identification in urine samples of multi-drug–resistant bacterial and fungal strains in patients after OLT such as ESBL(+) 38.5%; HLAR 80.4%; VRE 17.6%; and MRSA/MRCNS 100% requires better infection control.</description><identifier>ISSN: 0041-1345</identifier><identifier>EISSN: 1873-2623</identifier><identifier>DOI: 10.1016/j.transproceed.2011.09.003</identifier><identifier>PMID: 21996222</identifier><identifier>CODEN: TRPPA8</identifier><language>eng</language><publisher>Amsterdam: Elsevier Inc</publisher><subject>Adult ; Bacterial diseases ; Bacterial diseases of the urinary system ; Bacterial Infections - etiology ; Bacterial Infections - microbiology ; Biological and medical sciences ; Drug Resistance, Multiple, Bacterial ; Drug Resistance, Multiple, Fungal ; Female ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; Human bacterial diseases ; Humans ; Infectious diseases ; Liver Transplantation - adverse effects ; Liver, biliary tract, pancreas, portal circulation, spleen ; Male ; Medical sciences ; Middle Aged ; Mycoses - etiology ; Mycoses - microbiology ; Postoperative Complications - etiology ; Postoperative Complications - microbiology ; Prospective Studies ; Risk Factors ; Surgery ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Surgery of the digestive system ; Time Factors ; Tissue, organ and graft immunology ; Urinary Tract Infections - etiology ; Urinary Tract Infections - microbiology</subject><ispartof>Transplantation proceedings, 2011-10, Vol.43 (8), p.3052-3054</ispartof><rights>Elsevier Inc.</rights><rights>2011 Elsevier Inc.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c464t-e0deae3d7761b8cefb7d133e27891f008acf1efffc9069063da488711a6969743</citedby><cites>FETCH-LOGICAL-c464t-e0deae3d7761b8cefb7d133e27891f008acf1efffc9069063da488711a6969743</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.transproceed.2011.09.003$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>309,310,314,780,784,789,790,3550,23930,23931,25140,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24724684$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21996222$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kawecki, D</creatorcontrib><creatorcontrib>Pacholczyk, M</creatorcontrib><creatorcontrib>Łagiewska, B</creatorcontrib><creatorcontrib>Adadyński, L</creatorcontrib><creatorcontrib>Lisik, W</creatorcontrib><creatorcontrib>Sawicka-Grzelak, A</creatorcontrib><creatorcontrib>Durlik, M</creatorcontrib><creatorcontrib>Paczek, L</creatorcontrib><creatorcontrib>Chmura, A</creatorcontrib><creatorcontrib>Mlynarczyk, G</creatorcontrib><creatorcontrib>Rowinski, W</creatorcontrib><creatorcontrib>Luczak, M</creatorcontrib><title>Urinary Tract Infections in the Early Posttransplant Period After Liver Transplantation: Etiologic Agents and Their Susceptibility</title><title>Transplantation proceedings</title><addtitle>Transplant Proc</addtitle><description>Abstract Background We performed an analysis of etiologic agents for urinary tract infections in the early posttransplant period after orthotopic liver transplantation (OLT) in adult recipients. Patients and Methods The study covered the first 4 weeks after OLT of 190 patients from September 2001 to the end of 2007. Immunosuppression consisted of steroids and tacrolimus. Antimicrobial prophylaxis was piperacillin/tazobactam, fluconazole, and SBD. Urine samples were cultured to identify microorganisms in accord with standard microbiological procedures and to test susceptibility using Clinical Laboratory and Standards Institute guidelines. Results Urine specimens ( n = 539) examined from 185 recipients (97.4%) showed 210 microbial strains. The most common were Gram-negative ( n = 131; 62.4%) with predominance of Escherichia coli (28.2%), Enterobacter cloacae (19.1%), and Acinetobacter baumannii (11.4%). Extended-spectrum β- lactamases (ESBL(+)) strains were isolated in 38.5% of cases. Gram-positive bacteria comprised 28.6% ( n = 60): The most common strains were enterococci (85% including HLAR 80.4% and VRE 17.6%] and staphylococci 11.8% [MRSA/MRCNS; 100%]. There were 19 (9%) fungal strains. Conclusions In general, the identification in urine samples of multi-drug–resistant bacterial and fungal strains in patients after OLT such as ESBL(+) 38.5%; HLAR 80.4%; VRE 17.6%; and MRSA/MRCNS 100% requires better infection control.</description><subject>Adult</subject><subject>Bacterial diseases</subject><subject>Bacterial diseases of the urinary system</subject><subject>Bacterial Infections - etiology</subject><subject>Bacterial Infections - microbiology</subject><subject>Biological and medical sciences</subject><subject>Drug Resistance, Multiple, Bacterial</subject><subject>Drug Resistance, Multiple, Fungal</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>Human bacterial diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Liver Transplantation - adverse effects</subject><subject>Liver, biliary tract, pancreas, portal circulation, spleen</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Mycoses - etiology</subject><subject>Mycoses - microbiology</subject><subject>Postoperative Complications - etiology</subject><subject>Postoperative Complications - microbiology</subject><subject>Prospective Studies</subject><subject>Risk Factors</subject><subject>Surgery</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Surgery of the digestive system</subject><subject>Time Factors</subject><subject>Tissue, organ and graft immunology</subject><subject>Urinary Tract Infections - etiology</subject><subject>Urinary Tract Infections - microbiology</subject><issn>0041-1345</issn><issn>1873-2623</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNUl1rFDEUDaLYbfUvSBDEpxnz1ZmkD8JSVy0sWOgWfAvZzE2bdTazJpnCvvrLm2G3Kj4JISHcc889nHMRektJTQltPmzqHE1IuzhYgK5mhNKaqJoQ_gzNqGx5xRrGn6MZIYJWlIvzE3Sa0oaUPxP8JTphVKmGMTZDv26jDybu8Soam_FVcGCzH0LCPuB8D3hhYr_H10PKh6G9CRlfQ_RDh-cuQ8RL_1Du1e-qmfov8KI8_XDnLZ7fQcgJm9Dh1T34iG_GZGGX_dr3Pu9foRfO9AleH98zdPt5sbr8Wi2_fbm6nC8rKxqRKyAdGOBd2zZ0LS24ddtRzoG1UlFHiDTWUXDOWUWacnhnhJQtpaZRjWoFP0PvD7zFuJ8jpKy3vujoi2YYxqSlkudECMYL8uKAtHFIKYLTu-i3xSVNiZ4i0Bv9dwR6ikATpUsEpfnNccy43pbaU-uT5wXw7ggwyZreFSLr0x-caJlo5KT30wEHxZQHD1En6yFY6HwsIelu8P-n5-M_NLb3wZfJP2APaTOMMRTbNdWJaaJvpqWZdoYWYtrK7_wRI8rDTw</recordid><startdate>20111001</startdate><enddate>20111001</enddate><creator>Kawecki, D</creator><creator>Pacholczyk, M</creator><creator>Łagiewska, B</creator><creator>Adadyński, L</creator><creator>Lisik, W</creator><creator>Sawicka-Grzelak, A</creator><creator>Durlik, M</creator><creator>Paczek, L</creator><creator>Chmura, A</creator><creator>Mlynarczyk, G</creator><creator>Rowinski, W</creator><creator>Luczak, M</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20111001</creationdate><title>Urinary Tract Infections in the Early Posttransplant Period After Liver Transplantation: Etiologic Agents and Their Susceptibility</title><author>Kawecki, D ; Pacholczyk, M ; Łagiewska, B ; Adadyński, L ; Lisik, W ; Sawicka-Grzelak, A ; Durlik, M ; Paczek, L ; Chmura, A ; Mlynarczyk, G ; Rowinski, W ; Luczak, M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c464t-e0deae3d7761b8cefb7d133e27891f008acf1efffc9069063da488711a6969743</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adult</topic><topic>Bacterial diseases</topic><topic>Bacterial diseases of the urinary system</topic><topic>Bacterial Infections - etiology</topic><topic>Bacterial Infections - microbiology</topic><topic>Biological and medical sciences</topic><topic>Drug Resistance, Multiple, Bacterial</topic><topic>Drug Resistance, Multiple, Fungal</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>Human bacterial diseases</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Liver Transplantation - adverse effects</topic><topic>Liver, biliary tract, pancreas, portal circulation, spleen</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Mycoses - etiology</topic><topic>Mycoses - microbiology</topic><topic>Postoperative Complications - etiology</topic><topic>Postoperative Complications - microbiology</topic><topic>Prospective Studies</topic><topic>Risk Factors</topic><topic>Surgery</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Surgery of the digestive system</topic><topic>Time Factors</topic><topic>Tissue, organ and graft immunology</topic><topic>Urinary Tract Infections - etiology</topic><topic>Urinary Tract Infections - microbiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kawecki, D</creatorcontrib><creatorcontrib>Pacholczyk, M</creatorcontrib><creatorcontrib>Łagiewska, B</creatorcontrib><creatorcontrib>Adadyński, L</creatorcontrib><creatorcontrib>Lisik, W</creatorcontrib><creatorcontrib>Sawicka-Grzelak, A</creatorcontrib><creatorcontrib>Durlik, M</creatorcontrib><creatorcontrib>Paczek, L</creatorcontrib><creatorcontrib>Chmura, A</creatorcontrib><creatorcontrib>Mlynarczyk, G</creatorcontrib><creatorcontrib>Rowinski, W</creatorcontrib><creatorcontrib>Luczak, M</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Transplantation proceedings</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kawecki, D</au><au>Pacholczyk, M</au><au>Łagiewska, B</au><au>Adadyński, L</au><au>Lisik, W</au><au>Sawicka-Grzelak, A</au><au>Durlik, M</au><au>Paczek, L</au><au>Chmura, A</au><au>Mlynarczyk, G</au><au>Rowinski, W</au><au>Luczak, M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Urinary Tract Infections in the Early Posttransplant Period After Liver Transplantation: Etiologic Agents and Their Susceptibility</atitle><jtitle>Transplantation proceedings</jtitle><addtitle>Transplant Proc</addtitle><date>2011-10-01</date><risdate>2011</risdate><volume>43</volume><issue>8</issue><spage>3052</spage><epage>3054</epage><pages>3052-3054</pages><issn>0041-1345</issn><eissn>1873-2623</eissn><coden>TRPPA8</coden><abstract>Abstract Background We performed an analysis of etiologic agents for urinary tract infections in the early posttransplant period after orthotopic liver transplantation (OLT) in adult recipients. Patients and Methods The study covered the first 4 weeks after OLT of 190 patients from September 2001 to the end of 2007. Immunosuppression consisted of steroids and tacrolimus. Antimicrobial prophylaxis was piperacillin/tazobactam, fluconazole, and SBD. Urine samples were cultured to identify microorganisms in accord with standard microbiological procedures and to test susceptibility using Clinical Laboratory and Standards Institute guidelines. Results Urine specimens ( n = 539) examined from 185 recipients (97.4%) showed 210 microbial strains. The most common were Gram-negative ( n = 131; 62.4%) with predominance of Escherichia coli (28.2%), Enterobacter cloacae (19.1%), and Acinetobacter baumannii (11.4%). Extended-spectrum β- lactamases (ESBL(+)) strains were isolated in 38.5% of cases. Gram-positive bacteria comprised 28.6% ( n = 60): The most common strains were enterococci (85% including HLAR 80.4% and VRE 17.6%] and staphylococci 11.8% [MRSA/MRCNS; 100%]. There were 19 (9%) fungal strains. Conclusions In general, the identification in urine samples of multi-drug–resistant bacterial and fungal strains in patients after OLT such as ESBL(+) 38.5%; HLAR 80.4%; VRE 17.6%; and MRSA/MRCNS 100% requires better infection control.</abstract><cop>Amsterdam</cop><pub>Elsevier Inc</pub><pmid>21996222</pmid><doi>10.1016/j.transproceed.2011.09.003</doi><tpages>3</tpages></addata></record> |
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| subjects | Adult Bacterial diseases Bacterial diseases of the urinary system Bacterial Infections - etiology Bacterial Infections - microbiology Biological and medical sciences Drug Resistance, Multiple, Bacterial Drug Resistance, Multiple, Fungal Female Fundamental and applied biological sciences. Psychology Fundamental immunology Human bacterial diseases Humans Infectious diseases Liver Transplantation - adverse effects Liver, biliary tract, pancreas, portal circulation, spleen Male Medical sciences Middle Aged Mycoses - etiology Mycoses - microbiology Postoperative Complications - etiology Postoperative Complications - microbiology Prospective Studies Risk Factors Surgery Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the digestive system Time Factors Tissue, organ and graft immunology Urinary Tract Infections - etiology Urinary Tract Infections - microbiology |
| title | Urinary Tract Infections in the Early Posttransplant Period After Liver Transplantation: Etiologic Agents and Their Susceptibility |
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