Stem-cell therapy in an experimental model of pulmonary hypertension and right heart failure: Role of paracrine and neurohormonal milieu in the remodeling process

Background In this study we investigated the effect of human amniotic fluid stem (hAFS) cells and rat adipose tissue stromal vascular fraction GFP-positive cell (rSVC-GFP) therapy and the contribution of the paracrine and neurohormonal milieu to cardiac and pulmonary vascular remodeling in a rat mod...

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Veröffentlicht in:	The Journal of heart and lung transplantation 2011-11, Vol.30 (11), p.1281-1293
Hauptverfasser:	Angelini, Annalisa, MD, Castellani, Chiara, BSc, PhD, Ravara, Barbara, BSc, Franzin, Chiara, BSc, PhD, Pozzobon, Michela, BSc, PhD, Tavano, Regina, BSc, PhD, Libera, Luciano Dalla, DChem, Papini, Emanuele, BSc, PhD, Vettor, Roberto, MD, De Coppi, Paolo, MD, PhD, Thiene, Gaetano, MD, Vescovo, Giorgio, MD, PhD
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences BNP Cardiology. Vascular system cytokines Cytokines - metabolism Disease Models, Animal Flow Cytometry Heart heart failure Heart Failure - complications Heart Failure - physiopathology Heart Failure - therapy Heart failure, cardiogenic pulmonary edema, cardiac enlargement Heart Ventricles - metabolism Heart Ventricles - pathology Hypertension, Pulmonary - complications Hypertension, Pulmonary - physiopathology Hypertension, Pulmonary - therapy Hypertrophy, Right Ventricular - complications Hypertrophy, Right Ventricular - physiopathology Hypertrophy, Right Ventricular - therapy Immunohistochemistry Male Medical sciences monocrotaline Neurotransmitter Agents - pharmacology Pneumology Pulmonary hypertension. Acute cor pulmonale. Pulmonary embolism. Pulmonary vascular diseases Rats Rats, Sprague-Dawley Stem Cell Transplantation - methods stem cells Surgery Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the heart Treatment Outcome Ventricular Remodeling - drug effects
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