Efavirenz is a substrate and in turn modulates the expression of the efflux transporter ABCG2/BCRP in the gastrointestinal tract of the rat

The oral bioavailability of the antiretroviral efavirenz (EFV) undergoes high inter and intra-individual variability, this fact supporting its therapeutic drug monitoring. Previously, it was demonstrated that the encapsulation of EFV within polymeric micelles increases the oral bioavailability of th...

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Veröffentlicht in:	Biochemical pharmacology 2011-11, Vol.82 (9), p.1227-1233
Hauptverfasser:	Peroni, Roxana N., Di Gennaro, Stefania S., Hocht, Christian, Chiappetta, Diego A., Rubio, Modesto C., Sosnik, Alejandro, Bramuglia, Guillermo F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Abcg2 absorption Administration, Oral Animals Anti-HIV Agents - pharmacokinetics Anti-HIV Agents - pharmacology ATP Binding Cassette Transporter, Sub-Family G, Member 2 ATP-Binding Cassette Transporters - genetics ATP-Binding Cassette Transporters - metabolism Benzoxazines - administration & dosage Benzoxazines - pharmacokinetics Benzoxazines - pharmacology bioavailability Biological and medical sciences Biological Availability breast neoplasms Dose-Response Relationship, Drug drugs Efavirenz encapsulation Gastrointestinal Tract - metabolism Gene Expression Regulation - drug effects Hiv Human viral diseases Immunodeficiencies Immunodeficiencies. Immunoglobulinopathies Immunopathology Infectious diseases Intestine Male Medical sciences micelles monitoring oral administration Oral bioavailability permeability Pharmacology. Drug treatments Rats Rats, Sprague-Dawley small intestine Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids
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