Incremental effects of serum uric acid levels, autonomic dysfunction, and low-grade inflammation on nocturnal blood pressure in untreated hypertensive patients and normotensive individuals
We aimed to evaluate the associations between nocturnal blood pressure (BP) and serum uric acid (SUA) level, low-grade inflammation, and cardiac autonomic function in untreated dipper and nondipper hypertensive patients and normotensive individuals. The study included 92 consecutive patients (44 men...
Gespeichert in:
| Veröffentlicht in: | Türk Kardiyoloji Derneği arşivi 2011-10, Vol.39 (7), p.531-539 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 539 |
|---|---|
| container_issue | 7 |
| container_start_page | 531 |
| container_title | Türk Kardiyoloji Derneği arşivi |
| container_volume | 39 |
| creator | Erden, Murat Kocaman, Sinan Altan Poyraz, Fatih Topal, Salih Sahinarslan, Asife Boyacı, Bülent Cengel, Atiye Yalçın, Mehmet Ridvan |
| description | We aimed to evaluate the associations between nocturnal blood pressure (BP) and serum uric acid (SUA) level, low-grade inflammation, and cardiac autonomic function in untreated dipper and nondipper hypertensive patients and normotensive individuals.
The study included 92 consecutive patients (44 men, 48 women; mean age 51.6 ± 9.7 years) who presented for initial evaluation of hypertension. All patients underwent 24-hour Holter monitoring to assess heart rate variability (HRV) and ambulatory BP. Serum high-sensitivity C-reactive protein (hs-CRP) and SUA levels were measured. Due to the non-normal distribution of hs-CRP and microalbuminuria (MAU), they were normalized by logarithmic transformation.
Of the study group, 60 patients (65.2%) were diagnosed as hypertensive (50% nondippers). In univariate correlation analysis, log(MAU) showed a significant correlation with nocturnal BP (r=0.560, p |
| doi_str_mv | 10.5543/tkda.2011.01545 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_897812382</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>897812382</sourcerecordid><originalsourceid>FETCH-LOGICAL-c296t-1a95e617b52ab6bb26ab73b66d91b5ad3090ef12aae43267044e4b081444a2c63</originalsourceid><addsrcrecordid>eNo9kctu1TAQhi0EolXpmh3yjg059S1OskQVl0qV2LTryJcJGGI7-HLQeTceDqcXRiPNaOab35Z-hN5Scuh7wa_KL6sOjFB6ILQX_Qt0TjkZOyHG8WXrCZVdT-V0hi5z_klaiInTfniNzhidRj5Ido7-3gSTwEMoasWwLGBKxnHBGVL1uCZnsDLO4hWOsOYPWNUSQ_RtbE95qcEUF0Mbh4bEP933pCxgF5ZVea_2HW4Zoik1hfaCXmO0eEuQc007iGsoCVQBi3-cNkgFQnZHwFs7bp_KD8ohJh-fNy5Yd3S2qjW_Qa-WVuDyqV6g-8-f7q6_drffvtxcf7ztDJtk6aiaepB00D1TWmrNpNID11LaiepeWU4mAgtlSoHgTA5ECBCajFQIoZiR_AK9f9TdUvxdIZfZu2xgXVWAWPM8TsNIGR9ZI68eSZNizgmWeUvOq3SaKZl30-bdtHk3bX4wrV28e9Ku2oP9zz9bxP8B3GaY3Q</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>897812382</pqid></control><display><type>article</type><title>Incremental effects of serum uric acid levels, autonomic dysfunction, and low-grade inflammation on nocturnal blood pressure in untreated hypertensive patients and normotensive individuals</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Alma/SFX Local Collection</source><creator>Erden, Murat ; Kocaman, Sinan Altan ; Poyraz, Fatih ; Topal, Salih ; Sahinarslan, Asife ; Boyacı, Bülent ; Cengel, Atiye ; Yalçın, Mehmet Ridvan</creator><creatorcontrib>Erden, Murat ; Kocaman, Sinan Altan ; Poyraz, Fatih ; Topal, Salih ; Sahinarslan, Asife ; Boyacı, Bülent ; Cengel, Atiye ; Yalçın, Mehmet Ridvan</creatorcontrib><description>We aimed to evaluate the associations between nocturnal blood pressure (BP) and serum uric acid (SUA) level, low-grade inflammation, and cardiac autonomic function in untreated dipper and nondipper hypertensive patients and normotensive individuals.
The study included 92 consecutive patients (44 men, 48 women; mean age 51.6 ± 9.7 years) who presented for initial evaluation of hypertension. All patients underwent 24-hour Holter monitoring to assess heart rate variability (HRV) and ambulatory BP. Serum high-sensitivity C-reactive protein (hs-CRP) and SUA levels were measured. Due to the non-normal distribution of hs-CRP and microalbuminuria (MAU), they were normalized by logarithmic transformation.
Of the study group, 60 patients (65.2%) were diagnosed as hypertensive (50% nondippers). In univariate correlation analysis, log(MAU) showed a significant correlation with nocturnal BP (r=0.560, p<0.001). Among HRV parameters, SDNN, SDANN, and triangular index were inversely correlated with log(hs-CRP) (r=-0.356, p=0.001; r=-0.350, p=0.001; r=-0.314, p=0.002, respectively) and nighttime BP (r=-0.286, p=0.006; r=-0.251, p=0.02; r=-0.294, p=0.004, respectively). Log(hs-CRP) was positively correlated with nighttime BP (r=0.302, p=0.003). Serum UA levels were correlated with only nocturnal BP; i.e., nocturnal mean (r=0.260, p=0.01), systolic (r=0.249, p=0.016), and diastolic BP (r=0.249, p=0.017). In multiple linear regression analysis, log(hs-CRP) and age were independent predictors of cardiac autonomic dysfunction, and log(hs-CRP), SUA, and HRV parameters were independent predictors of nocturnal BP measurements.
Our findings suggest the role of low-grade inflammation, uric acid levels, and autonomic dysfunction even in the early stages of hypertension.</description><identifier>ISSN: 1016-5169</identifier><identifier>EISSN: 1308-4488</identifier><identifier>DOI: 10.5543/tkda.2011.01545</identifier><identifier>PMID: 21983762</identifier><language>eng</language><publisher>Turkey</publisher><subject>Autonomic Nervous System ; Blood Pressure ; C-Reactive Protein - metabolism ; Circadian Rhythm ; Cross-Sectional Studies ; Electrocardiography, Ambulatory ; Female ; Humans ; Hypertension - blood ; Hypertension - physiopathology ; Male ; Middle Aged ; Uric Acid - blood</subject><ispartof>Türk Kardiyoloji Derneği arşivi, 2011-10, Vol.39 (7), p.531-539</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c296t-1a95e617b52ab6bb26ab73b66d91b5ad3090ef12aae43267044e4b081444a2c63</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21983762$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Erden, Murat</creatorcontrib><creatorcontrib>Kocaman, Sinan Altan</creatorcontrib><creatorcontrib>Poyraz, Fatih</creatorcontrib><creatorcontrib>Topal, Salih</creatorcontrib><creatorcontrib>Sahinarslan, Asife</creatorcontrib><creatorcontrib>Boyacı, Bülent</creatorcontrib><creatorcontrib>Cengel, Atiye</creatorcontrib><creatorcontrib>Yalçın, Mehmet Ridvan</creatorcontrib><title>Incremental effects of serum uric acid levels, autonomic dysfunction, and low-grade inflammation on nocturnal blood pressure in untreated hypertensive patients and normotensive individuals</title><title>Türk Kardiyoloji Derneği arşivi</title><addtitle>Turk Kardiyol Dern Ars</addtitle><description>We aimed to evaluate the associations between nocturnal blood pressure (BP) and serum uric acid (SUA) level, low-grade inflammation, and cardiac autonomic function in untreated dipper and nondipper hypertensive patients and normotensive individuals.
The study included 92 consecutive patients (44 men, 48 women; mean age 51.6 ± 9.7 years) who presented for initial evaluation of hypertension. All patients underwent 24-hour Holter monitoring to assess heart rate variability (HRV) and ambulatory BP. Serum high-sensitivity C-reactive protein (hs-CRP) and SUA levels were measured. Due to the non-normal distribution of hs-CRP and microalbuminuria (MAU), they were normalized by logarithmic transformation.
Of the study group, 60 patients (65.2%) were diagnosed as hypertensive (50% nondippers). In univariate correlation analysis, log(MAU) showed a significant correlation with nocturnal BP (r=0.560, p<0.001). Among HRV parameters, SDNN, SDANN, and triangular index were inversely correlated with log(hs-CRP) (r=-0.356, p=0.001; r=-0.350, p=0.001; r=-0.314, p=0.002, respectively) and nighttime BP (r=-0.286, p=0.006; r=-0.251, p=0.02; r=-0.294, p=0.004, respectively). Log(hs-CRP) was positively correlated with nighttime BP (r=0.302, p=0.003). Serum UA levels were correlated with only nocturnal BP; i.e., nocturnal mean (r=0.260, p=0.01), systolic (r=0.249, p=0.016), and diastolic BP (r=0.249, p=0.017). In multiple linear regression analysis, log(hs-CRP) and age were independent predictors of cardiac autonomic dysfunction, and log(hs-CRP), SUA, and HRV parameters were independent predictors of nocturnal BP measurements.
Our findings suggest the role of low-grade inflammation, uric acid levels, and autonomic dysfunction even in the early stages of hypertension.</description><subject>Autonomic Nervous System</subject><subject>Blood Pressure</subject><subject>C-Reactive Protein - metabolism</subject><subject>Circadian Rhythm</subject><subject>Cross-Sectional Studies</subject><subject>Electrocardiography, Ambulatory</subject><subject>Female</subject><subject>Humans</subject><subject>Hypertension - blood</subject><subject>Hypertension - physiopathology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Uric Acid - blood</subject><issn>1016-5169</issn><issn>1308-4488</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kctu1TAQhi0EolXpmh3yjg059S1OskQVl0qV2LTryJcJGGI7-HLQeTceDqcXRiPNaOab35Z-hN5Scuh7wa_KL6sOjFB6ILQX_Qt0TjkZOyHG8WXrCZVdT-V0hi5z_klaiInTfniNzhidRj5Ido7-3gSTwEMoasWwLGBKxnHBGVL1uCZnsDLO4hWOsOYPWNUSQ_RtbE95qcEUF0Mbh4bEP933pCxgF5ZVea_2HW4Zoik1hfaCXmO0eEuQc007iGsoCVQBi3-cNkgFQnZHwFs7bp_KD8ohJh-fNy5Yd3S2qjW_Qa-WVuDyqV6g-8-f7q6_drffvtxcf7ztDJtk6aiaepB00D1TWmrNpNID11LaiepeWU4mAgtlSoHgTA5ECBCajFQIoZiR_AK9f9TdUvxdIZfZu2xgXVWAWPM8TsNIGR9ZI68eSZNizgmWeUvOq3SaKZl30-bdtHk3bX4wrV28e9Ku2oP9zz9bxP8B3GaY3Q</recordid><startdate>201110</startdate><enddate>201110</enddate><creator>Erden, Murat</creator><creator>Kocaman, Sinan Altan</creator><creator>Poyraz, Fatih</creator><creator>Topal, Salih</creator><creator>Sahinarslan, Asife</creator><creator>Boyacı, Bülent</creator><creator>Cengel, Atiye</creator><creator>Yalçın, Mehmet Ridvan</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201110</creationdate><title>Incremental effects of serum uric acid levels, autonomic dysfunction, and low-grade inflammation on nocturnal blood pressure in untreated hypertensive patients and normotensive individuals</title><author>Erden, Murat ; Kocaman, Sinan Altan ; Poyraz, Fatih ; Topal, Salih ; Sahinarslan, Asife ; Boyacı, Bülent ; Cengel, Atiye ; Yalçın, Mehmet Ridvan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c296t-1a95e617b52ab6bb26ab73b66d91b5ad3090ef12aae43267044e4b081444a2c63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Autonomic Nervous System</topic><topic>Blood Pressure</topic><topic>C-Reactive Protein - metabolism</topic><topic>Circadian Rhythm</topic><topic>Cross-Sectional Studies</topic><topic>Electrocardiography, Ambulatory</topic><topic>Female</topic><topic>Humans</topic><topic>Hypertension - blood</topic><topic>Hypertension - physiopathology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Uric Acid - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Erden, Murat</creatorcontrib><creatorcontrib>Kocaman, Sinan Altan</creatorcontrib><creatorcontrib>Poyraz, Fatih</creatorcontrib><creatorcontrib>Topal, Salih</creatorcontrib><creatorcontrib>Sahinarslan, Asife</creatorcontrib><creatorcontrib>Boyacı, Bülent</creatorcontrib><creatorcontrib>Cengel, Atiye</creatorcontrib><creatorcontrib>Yalçın, Mehmet Ridvan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Türk Kardiyoloji Derneği arşivi</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Erden, Murat</au><au>Kocaman, Sinan Altan</au><au>Poyraz, Fatih</au><au>Topal, Salih</au><au>Sahinarslan, Asife</au><au>Boyacı, Bülent</au><au>Cengel, Atiye</au><au>Yalçın, Mehmet Ridvan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Incremental effects of serum uric acid levels, autonomic dysfunction, and low-grade inflammation on nocturnal blood pressure in untreated hypertensive patients and normotensive individuals</atitle><jtitle>Türk Kardiyoloji Derneği arşivi</jtitle><addtitle>Turk Kardiyol Dern Ars</addtitle><date>2011-10</date><risdate>2011</risdate><volume>39</volume><issue>7</issue><spage>531</spage><epage>539</epage><pages>531-539</pages><issn>1016-5169</issn><eissn>1308-4488</eissn><abstract>We aimed to evaluate the associations between nocturnal blood pressure (BP) and serum uric acid (SUA) level, low-grade inflammation, and cardiac autonomic function in untreated dipper and nondipper hypertensive patients and normotensive individuals.
The study included 92 consecutive patients (44 men, 48 women; mean age 51.6 ± 9.7 years) who presented for initial evaluation of hypertension. All patients underwent 24-hour Holter monitoring to assess heart rate variability (HRV) and ambulatory BP. Serum high-sensitivity C-reactive protein (hs-CRP) and SUA levels were measured. Due to the non-normal distribution of hs-CRP and microalbuminuria (MAU), they were normalized by logarithmic transformation.
Of the study group, 60 patients (65.2%) were diagnosed as hypertensive (50% nondippers). In univariate correlation analysis, log(MAU) showed a significant correlation with nocturnal BP (r=0.560, p<0.001). Among HRV parameters, SDNN, SDANN, and triangular index were inversely correlated with log(hs-CRP) (r=-0.356, p=0.001; r=-0.350, p=0.001; r=-0.314, p=0.002, respectively) and nighttime BP (r=-0.286, p=0.006; r=-0.251, p=0.02; r=-0.294, p=0.004, respectively). Log(hs-CRP) was positively correlated with nighttime BP (r=0.302, p=0.003). Serum UA levels were correlated with only nocturnal BP; i.e., nocturnal mean (r=0.260, p=0.01), systolic (r=0.249, p=0.016), and diastolic BP (r=0.249, p=0.017). In multiple linear regression analysis, log(hs-CRP) and age were independent predictors of cardiac autonomic dysfunction, and log(hs-CRP), SUA, and HRV parameters were independent predictors of nocturnal BP measurements.
Our findings suggest the role of low-grade inflammation, uric acid levels, and autonomic dysfunction even in the early stages of hypertension.</abstract><cop>Turkey</cop><pmid>21983762</pmid><doi>10.5543/tkda.2011.01545</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1016-5169 |
| ispartof | Türk Kardiyoloji Derneği arşivi, 2011-10, Vol.39 (7), p.531-539 |
| issn | 1016-5169 1308-4488 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_897812382 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Autonomic Nervous System Blood Pressure C-Reactive Protein - metabolism Circadian Rhythm Cross-Sectional Studies Electrocardiography, Ambulatory Female Humans Hypertension - blood Hypertension - physiopathology Male Middle Aged Uric Acid - blood |
| title | Incremental effects of serum uric acid levels, autonomic dysfunction, and low-grade inflammation on nocturnal blood pressure in untreated hypertensive patients and normotensive individuals |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-27T01%3A37%3A59IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Incremental%20effects%20of%20serum%20uric%20acid%20levels,%20autonomic%20dysfunction,%20and%20low-grade%20inflammation%20on%20nocturnal%20blood%20pressure%20in%20untreated%20hypertensive%20patients%20and%20normotensive%20individuals&rft.jtitle=T%C3%BCrk%20Kardiyoloji%20Derne%C4%9Fi%20ar%C5%9Fivi&rft.au=Erden,%20Murat&rft.date=2011-10&rft.volume=39&rft.issue=7&rft.spage=531&rft.epage=539&rft.pages=531-539&rft.issn=1016-5169&rft.eissn=1308-4488&rft_id=info:doi/10.5543/tkda.2011.01545&rft_dat=%3Cproquest_cross%3E897812382%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=897812382&rft_id=info:pmid/21983762&rfr_iscdi=true |