Atypical neurofibromas in neurofibromatosis type 1 are premalignant tumors

Benign peripheral nerve sheath tumors (PNSTs) are a characteristic feature of neurofibromatosis type I (NF1) patients. NF1 individuals have an 8–13% lifetime risk of developing a malignant PNST (MPNST). Atypical neurofibromas are symptomatic, hypercellular PNSTs, composed of cells with hyperchromati...

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Veröffentlicht in:	Genes chromosomes & cancer 2011-12, Vol.50 (12), p.1021-1032
Hauptverfasser:	Beert, Eline, Brems, Hilde, Daniëls, Bruno, De Wever, Ivo, Van Calenbergh, Frank, Schoenaers, Joseph, Debiec-Rychter, Maria, Gevaert, Olivier, De Raedt, Thomas, Van Den Bruel, Annick, de Ravel, Thomy, Cichowski, Karen, Kluwe, Lan, Mautner, Victor, Sciot, Raf, Legius, Eric
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Benign Child Chromosome Aberrations Chromosome deletion Chromosomes Comparative Genomic Hybridization - methods copy number Cyclin-Dependent Kinase Inhibitor p15 - genetics Cyclin-Dependent Kinase Inhibitor p16 - genetics Data processing DNA Copy Number Variations DNA microarrays Gene deletion Genes, Neurofibromatosis 1 Genomes Humans Karyotyping - methods Male Middle Aged Mutation Nerve Sheath Neoplasms - genetics Nerve Sheath Neoplasms - pathology Neurofibroma - genetics Neurofibroma - pathology Neurofibromatosis Neurofibromatosis 1 - genetics Neurofibromatosis 1 - pathology Peripheral nerves plexiform neurofibroma Precancerous Conditions - genetics Precancerous Conditions - pathology Recklinghausen's disease Risk Factors Sheaths Tumor Cells, Cultured Tumor Suppressor Protein p53 - genetics Tumors Young Adult
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