A genome-wide association study identifies two new risk loci for Graves' disease
Huai-Dong Song and colleagues report results of a genome-wide association study of Graves' disease. They confirm four previously reported risk loci for this disease and identify two new susceptibility loci at 4p14 and 6q27. Graves' disease is a common autoimmune disorder characterized by t...
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| Veröffentlicht in: | Nature genetics 2011-09, Vol.43 (9), p.897-901 |
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| creator | XUN CHU PAN, Chun-Ming WEI LIU FANG XIE YANG, Shao-Ying WANG, Hai-Feng SHI, Jing-Yi SUN, Wei-Wei DU, Wen-Hua ZUO, Chun-Lin SHI, Jin-Xiu LIU, Bing-Li ZHAO, Shuang-Xia GUO, Cui-Cui MING ZHAN GU, Zhao-Hui ZHANG, Xiao-Na FEI SUN WANG, Zhi-Quan SONG, Zhi-Yi ZOU, Cai-Yan SUN, Wei-Hua TING GUO JUN LIANG CAO, Huang-Ming MA, Jun-Hua BING HAN PING LI HE JIANG HUANG, Qiu-Hua LIMING LIANG LIU, Li-Bin GANG CHEN QING SU GAO, Guan-Qi PENG, Yong-De ZHAO, Jia-Jun GUANG NING ZHU CHEN CHEN, Jia-Lun CHEN, Sai-Juan WEI HUANG SONG, Huai-Dong ZHANG, Xiao-Mei YUAN, Guo-Yue LI, Chang-Gui XUE, Li-Qiong MIN SHEN |
| description | Huai-Dong Song and colleagues report results of a genome-wide association study of Graves' disease. They confirm four previously reported risk loci for this disease and identify two new susceptibility loci at 4p14 and 6q27.
Graves' disease is a common autoimmune disorder characterized by thyroid stimulating hormone receptor autoantibodies (TRAb) and hyperthyroidism. To investigate the genetic architecture of Graves' disease, we conducted a genome-wide association study in 1,536 individuals with Graves' disease (cases) and 1,516 controls. We further evaluated a group of associated SNPs in a second set of 3,994 cases and 3,510 controls. We confirmed four previously reported loci (in the major histocompatibility complex,
TSHR
,
CTLA4
and
FCRL3
) and identified two new susceptibility loci (the
RNASET2-FGFR1OP-CCR6
region at 6q27 (
P
combined
= 6.85 × 10
−10
for rs9355610) and an intergenic region at 4p14 (
P
combined
= 1.08 × 10
−13
for rs6832151)). These newly associated SNPs were correlated with the expression levels of
RNASET2
at 6q27, of
CHRNA9
and of a previously uncharacterized gene at 4p14, respectively. Moreover, we identified strong associations of
TSHR
and major histocompatibility complex class II variants with persistently TRAb-positive Graves' disease. |
| doi_str_mv | 10.1038/ng.898 |
| format | Article |
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Graves' disease is a common autoimmune disorder characterized by thyroid stimulating hormone receptor autoantibodies (TRAb) and hyperthyroidism. To investigate the genetic architecture of Graves' disease, we conducted a genome-wide association study in 1,536 individuals with Graves' disease (cases) and 1,516 controls. We further evaluated a group of associated SNPs in a second set of 3,994 cases and 3,510 controls. We confirmed four previously reported loci (in the major histocompatibility complex,
TSHR
,
CTLA4
and
FCRL3
) and identified two new susceptibility loci (the
RNASET2-FGFR1OP-CCR6
region at 6q27 (
P
combined
= 6.85 × 10
−10
for rs9355610) and an intergenic region at 4p14 (
P
combined
= 1.08 × 10
−13
for rs6832151)). These newly associated SNPs were correlated with the expression levels of
RNASET2
at 6q27, of
CHRNA9
and of a previously uncharacterized gene at 4p14, respectively. Moreover, we identified strong associations of
TSHR
and major histocompatibility complex class II variants with persistently TRAb-positive Graves' disease.</description><identifier>ISSN: 1061-4036</identifier><identifier>EISSN: 1546-1718</identifier><identifier>DOI: 10.1038/ng.898</identifier><identifier>PMID: 21841780</identifier><identifier>CODEN: NGENEC</identifier><language>eng</language><publisher>New York: Nature Publishing Group US</publisher><subject>631/208/205/2138 ; 631/208/727/2000 ; 692/308/2779/174 ; 692/699/249/1313 ; Agriculture ; Animal Genetics and Genomics ; Autoantibodies - blood ; Biological and medical sciences ; Biomedical and Life Sciences ; Biomedicine ; Cancer Research ; Classical genetics, quantitative genetics, hybrids ; Disease ; Endocrinopathies ; Female ; Fundamental and applied biological sciences. Psychology ; Gene expression ; Gene Function ; Genetic aspects ; Genetic Loci ; Genetic Predisposition to Disease ; Genetics of eukaryotes. Biological and molecular evolution ; Genome-Wide Association Study ; Genomes ; Graves Disease - epidemiology ; Graves Disease - genetics ; Graves Disease - immunology ; Graves' disease ; Histocompatibility Antigens Class II - genetics ; Human ; Human Genetics ; Humans ; letter ; Male ; Medical sciences ; Molecular Sequence Data ; Non tumoral diseases. Target tissue resistance. Benign neoplasms ; Physiological aspects ; Polymerase chain reaction ; Principal components analysis ; Quality control ; Receptors, Thyrotropin - genetics ; Receptors, Thyrotropin - immunology ; Regression analysis ; Risk ; Risk factors ; Thyroid ; Thyroid. Thyroid axis (diseases)</subject><ispartof>Nature genetics, 2011-09, Vol.43 (9), p.897-901</ispartof><rights>Springer Nature America, Inc. 2011</rights><rights>2015 INIST-CNRS</rights><rights>COPYRIGHT 2011 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Sep 2011</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c601t-a9e29320db469e693e68e49948d689203457177c3ff380ff8e0acd06b6829f473</citedby><cites>FETCH-LOGICAL-c601t-a9e29320db469e693e68e49948d689203457177c3ff380ff8e0acd06b6829f473</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/ng.898$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/ng.898$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24566416$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21841780$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>XUN CHU</creatorcontrib><creatorcontrib>PAN, Chun-Ming</creatorcontrib><creatorcontrib>WEI LIU</creatorcontrib><creatorcontrib>FANG XIE</creatorcontrib><creatorcontrib>YANG, Shao-Ying</creatorcontrib><creatorcontrib>WANG, Hai-Feng</creatorcontrib><creatorcontrib>SHI, Jing-Yi</creatorcontrib><creatorcontrib>SUN, Wei-Wei</creatorcontrib><creatorcontrib>DU, Wen-Hua</creatorcontrib><creatorcontrib>ZUO, Chun-Lin</creatorcontrib><creatorcontrib>SHI, Jin-Xiu</creatorcontrib><creatorcontrib>LIU, Bing-Li</creatorcontrib><creatorcontrib>ZHAO, Shuang-Xia</creatorcontrib><creatorcontrib>GUO, Cui-Cui</creatorcontrib><creatorcontrib>MING ZHAN</creatorcontrib><creatorcontrib>GU, Zhao-Hui</creatorcontrib><creatorcontrib>ZHANG, Xiao-Na</creatorcontrib><creatorcontrib>FEI SUN</creatorcontrib><creatorcontrib>WANG, Zhi-Quan</creatorcontrib><creatorcontrib>SONG, Zhi-Yi</creatorcontrib><creatorcontrib>ZOU, Cai-Yan</creatorcontrib><creatorcontrib>SUN, Wei-Hua</creatorcontrib><creatorcontrib>TING GUO</creatorcontrib><creatorcontrib>JUN LIANG</creatorcontrib><creatorcontrib>CAO, Huang-Ming</creatorcontrib><creatorcontrib>MA, Jun-Hua</creatorcontrib><creatorcontrib>BING HAN</creatorcontrib><creatorcontrib>PING LI</creatorcontrib><creatorcontrib>HE JIANG</creatorcontrib><creatorcontrib>HUANG, Qiu-Hua</creatorcontrib><creatorcontrib>LIMING LIANG</creatorcontrib><creatorcontrib>LIU, Li-Bin</creatorcontrib><creatorcontrib>GANG CHEN</creatorcontrib><creatorcontrib>QING SU</creatorcontrib><creatorcontrib>GAO, Guan-Qi</creatorcontrib><creatorcontrib>PENG, Yong-De</creatorcontrib><creatorcontrib>ZHAO, Jia-Jun</creatorcontrib><creatorcontrib>GUANG NING</creatorcontrib><creatorcontrib>ZHU CHEN</creatorcontrib><creatorcontrib>CHEN, Jia-Lun</creatorcontrib><creatorcontrib>CHEN, Sai-Juan</creatorcontrib><creatorcontrib>WEI HUANG</creatorcontrib><creatorcontrib>SONG, Huai-Dong</creatorcontrib><creatorcontrib>ZHANG, Xiao-Mei</creatorcontrib><creatorcontrib>YUAN, Guo-Yue</creatorcontrib><creatorcontrib>LI, Chang-Gui</creatorcontrib><creatorcontrib>XUE, Li-Qiong</creatorcontrib><creatorcontrib>MIN SHEN</creatorcontrib><creatorcontrib>China Consortium for Genetics of Autoimmune Thyroid Disease</creatorcontrib><creatorcontrib>The China Consortium for the Genetics of Autoimmune Thyroid Disease</creatorcontrib><title>A genome-wide association study identifies two new risk loci for Graves' disease</title><title>Nature genetics</title><addtitle>Nat Genet</addtitle><addtitle>Nat Genet</addtitle><description>Huai-Dong Song and colleagues report results of a genome-wide association study of Graves' disease. They confirm four previously reported risk loci for this disease and identify two new susceptibility loci at 4p14 and 6q27.
Graves' disease is a common autoimmune disorder characterized by thyroid stimulating hormone receptor autoantibodies (TRAb) and hyperthyroidism. To investigate the genetic architecture of Graves' disease, we conducted a genome-wide association study in 1,536 individuals with Graves' disease (cases) and 1,516 controls. We further evaluated a group of associated SNPs in a second set of 3,994 cases and 3,510 controls. We confirmed four previously reported loci (in the major histocompatibility complex,
TSHR
,
CTLA4
and
FCRL3
) and identified two new susceptibility loci (the
RNASET2-FGFR1OP-CCR6
region at 6q27 (
P
combined
= 6.85 × 10
−10
for rs9355610) and an intergenic region at 4p14 (
P
combined
= 1.08 × 10
−13
for rs6832151)). These newly associated SNPs were correlated with the expression levels of
RNASET2
at 6q27, of
CHRNA9
and of a previously uncharacterized gene at 4p14, respectively. Moreover, we identified strong associations of
TSHR
and major histocompatibility complex class II variants with persistently TRAb-positive Graves' disease.</description><subject>631/208/205/2138</subject><subject>631/208/727/2000</subject><subject>692/308/2779/174</subject><subject>692/699/249/1313</subject><subject>Agriculture</subject><subject>Animal Genetics and Genomics</subject><subject>Autoantibodies - blood</subject><subject>Biological and medical sciences</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cancer Research</subject><subject>Classical genetics, quantitative genetics, hybrids</subject><subject>Disease</subject><subject>Endocrinopathies</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene expression</subject><subject>Gene Function</subject><subject>Genetic aspects</subject><subject>Genetic Loci</subject><subject>Genetic Predisposition to Disease</subject><subject>Genetics of eukaryotes. Biological and molecular evolution</subject><subject>Genome-Wide Association Study</subject><subject>Genomes</subject><subject>Graves Disease - epidemiology</subject><subject>Graves Disease - genetics</subject><subject>Graves Disease - immunology</subject><subject>Graves' disease</subject><subject>Histocompatibility Antigens Class II - genetics</subject><subject>Human</subject><subject>Human Genetics</subject><subject>Humans</subject><subject>letter</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Molecular Sequence Data</subject><subject>Non tumoral diseases. Target tissue resistance. Benign neoplasms</subject><subject>Physiological aspects</subject><subject>Polymerase chain reaction</subject><subject>Principal components analysis</subject><subject>Quality control</subject><subject>Receptors, Thyrotropin - genetics</subject><subject>Receptors, Thyrotropin - immunology</subject><subject>Regression analysis</subject><subject>Risk</subject><subject>Risk factors</subject><subject>Thyroid</subject><subject>Thyroid. Thyroid axis (diseases)</subject><issn>1061-4036</issn><issn>1546-1718</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqN0l1rFDEUBuBBFFur_gQJilYvZs3XZpLLpWgtFCp-3Q7ZzMmQOpu0OTOu_fem7OqyRURykZA8OeFNUlVPGZ0xKvTb2M-00feqQzaXqmYN0_fLmCpWSyrUQfUI8ZJSJiXVD6sDzrRkjaaH1ccF6SGmFdTr0AGxiMkFO4YUCY5Td0PKbByDD4BkXCcSYU1ywO9kKI74lMlptj8Aj0kXECzC4-qBtwPCk21_VH19_-7LyYf6_OL07GRxXjtF2VhbA9wITrulVAaUEaA0SGOk7pQ2nAo5b1jTOOG90NR7DdS6jqql0tx42Yij6nhT9yqn6wlwbFcBHQyDjZAmbLVRWkjeqCJf_1OW-5Oac67nhT6_Qy_TlGPJUepJxiVXoqAXG9TbAdoQfRqzdbc12wVXjSylGC9q9hdVWger4FIEH8r83oY3exuKGeHn2NsJsT37_On_7cW3fftqY11OiBl8e5XDyuabEvw2u25jX9LpAp9tw0_LFXR_2O_PUsDLLbDo7OCzjS7gzsm5UpKp3dNgWYo95N0t3jnyF2o30mA</recordid><startdate>20110901</startdate><enddate>20110901</enddate><creator>XUN CHU</creator><creator>PAN, Chun-Ming</creator><creator>WEI LIU</creator><creator>FANG XIE</creator><creator>YANG, Shao-Ying</creator><creator>WANG, Hai-Feng</creator><creator>SHI, Jing-Yi</creator><creator>SUN, Wei-Wei</creator><creator>DU, Wen-Hua</creator><creator>ZUO, Chun-Lin</creator><creator>SHI, Jin-Xiu</creator><creator>LIU, Bing-Li</creator><creator>ZHAO, Shuang-Xia</creator><creator>GUO, Cui-Cui</creator><creator>MING ZHAN</creator><creator>GU, Zhao-Hui</creator><creator>ZHANG, Xiao-Na</creator><creator>FEI SUN</creator><creator>WANG, Zhi-Quan</creator><creator>SONG, Zhi-Yi</creator><creator>ZOU, Cai-Yan</creator><creator>SUN, Wei-Hua</creator><creator>TING GUO</creator><creator>JUN LIANG</creator><creator>CAO, Huang-Ming</creator><creator>MA, Jun-Hua</creator><creator>BING HAN</creator><creator>PING LI</creator><creator>HE JIANG</creator><creator>HUANG, Qiu-Hua</creator><creator>LIMING LIANG</creator><creator>LIU, Li-Bin</creator><creator>GANG CHEN</creator><creator>QING SU</creator><creator>GAO, Guan-Qi</creator><creator>PENG, Yong-De</creator><creator>ZHAO, Jia-Jun</creator><creator>GUANG NING</creator><creator>ZHU CHEN</creator><creator>CHEN, Jia-Lun</creator><creator>CHEN, Sai-Juan</creator><creator>WEI HUANG</creator><creator>SONG, Huai-Dong</creator><creator>ZHANG, Xiao-Mei</creator><creator>YUAN, Guo-Yue</creator><creator>LI, Chang-Gui</creator><creator>XUE, Li-Qiong</creator><creator>MIN SHEN</creator><general>Nature Publishing Group US</general><general>Nature Publishing Group</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7SS</scope><scope>7T7</scope><scope>7TK</scope><scope>7TM</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7N</scope><scope>M7P</scope><scope>MBDVC</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20110901</creationdate><title>A genome-wide association study identifies two new risk loci for Graves' disease</title><author>XUN CHU ; PAN, Chun-Ming ; WEI LIU ; FANG XIE ; YANG, Shao-Ying ; WANG, Hai-Feng ; SHI, Jing-Yi ; SUN, Wei-Wei ; DU, Wen-Hua ; ZUO, Chun-Lin ; SHI, Jin-Xiu ; LIU, Bing-Li ; ZHAO, Shuang-Xia ; GUO, Cui-Cui ; MING ZHAN ; GU, Zhao-Hui ; ZHANG, Xiao-Na ; FEI SUN ; WANG, Zhi-Quan ; SONG, Zhi-Yi ; ZOU, Cai-Yan ; SUN, Wei-Hua ; TING GUO ; JUN LIANG ; CAO, Huang-Ming ; MA, Jun-Hua ; BING HAN ; PING LI ; HE JIANG ; HUANG, Qiu-Hua ; LIMING LIANG ; LIU, Li-Bin ; GANG CHEN ; QING SU ; GAO, Guan-Qi ; PENG, Yong-De ; ZHAO, Jia-Jun ; GUANG NING ; ZHU CHEN ; CHEN, Jia-Lun ; CHEN, Sai-Juan ; WEI HUANG ; SONG, Huai-Dong ; ZHANG, Xiao-Mei ; YUAN, Guo-Yue ; LI, Chang-Gui ; XUE, Li-Qiong ; MIN SHEN</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c601t-a9e29320db469e693e68e49948d689203457177c3ff380ff8e0acd06b6829f473</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>631/208/205/2138</topic><topic>631/208/727/2000</topic><topic>692/308/2779/174</topic><topic>692/699/249/1313</topic><topic>Agriculture</topic><topic>Animal Genetics and Genomics</topic><topic>Autoantibodies - blood</topic><topic>Biological and medical sciences</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cancer Research</topic><topic>Classical genetics, quantitative genetics, hybrids</topic><topic>Disease</topic><topic>Endocrinopathies</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene expression</topic><topic>Gene Function</topic><topic>Genetic aspects</topic><topic>Genetic Loci</topic><topic>Genetic Predisposition to Disease</topic><topic>Genetics of eukaryotes. Biological and molecular evolution</topic><topic>Genome-Wide Association Study</topic><topic>Genomes</topic><topic>Graves Disease - epidemiology</topic><topic>Graves Disease - genetics</topic><topic>Graves Disease - immunology</topic><topic>Graves' disease</topic><topic>Histocompatibility Antigens Class II - genetics</topic><topic>Human</topic><topic>Human Genetics</topic><topic>Humans</topic><topic>letter</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Molecular Sequence Data</topic><topic>Non tumoral diseases. Target tissue resistance. Benign neoplasms</topic><topic>Physiological aspects</topic><topic>Polymerase chain reaction</topic><topic>Principal components analysis</topic><topic>Quality control</topic><topic>Receptors, Thyrotropin - genetics</topic><topic>Receptors, Thyrotropin - immunology</topic><topic>Regression analysis</topic><topic>Risk</topic><topic>Risk factors</topic><topic>Thyroid</topic><topic>Thyroid. Thyroid axis (diseases)</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>XUN CHU</creatorcontrib><creatorcontrib>PAN, Chun-Ming</creatorcontrib><creatorcontrib>WEI LIU</creatorcontrib><creatorcontrib>FANG XIE</creatorcontrib><creatorcontrib>YANG, Shao-Ying</creatorcontrib><creatorcontrib>WANG, Hai-Feng</creatorcontrib><creatorcontrib>SHI, Jing-Yi</creatorcontrib><creatorcontrib>SUN, Wei-Wei</creatorcontrib><creatorcontrib>DU, Wen-Hua</creatorcontrib><creatorcontrib>ZUO, Chun-Lin</creatorcontrib><creatorcontrib>SHI, Jin-Xiu</creatorcontrib><creatorcontrib>LIU, Bing-Li</creatorcontrib><creatorcontrib>ZHAO, Shuang-Xia</creatorcontrib><creatorcontrib>GUO, Cui-Cui</creatorcontrib><creatorcontrib>MING ZHAN</creatorcontrib><creatorcontrib>GU, Zhao-Hui</creatorcontrib><creatorcontrib>ZHANG, Xiao-Na</creatorcontrib><creatorcontrib>FEI SUN</creatorcontrib><creatorcontrib>WANG, Zhi-Quan</creatorcontrib><creatorcontrib>SONG, Zhi-Yi</creatorcontrib><creatorcontrib>ZOU, Cai-Yan</creatorcontrib><creatorcontrib>SUN, Wei-Hua</creatorcontrib><creatorcontrib>TING GUO</creatorcontrib><creatorcontrib>JUN LIANG</creatorcontrib><creatorcontrib>CAO, Huang-Ming</creatorcontrib><creatorcontrib>MA, Jun-Hua</creatorcontrib><creatorcontrib>BING HAN</creatorcontrib><creatorcontrib>PING LI</creatorcontrib><creatorcontrib>HE JIANG</creatorcontrib><creatorcontrib>HUANG, Qiu-Hua</creatorcontrib><creatorcontrib>LIMING LIANG</creatorcontrib><creatorcontrib>LIU, Li-Bin</creatorcontrib><creatorcontrib>GANG CHEN</creatorcontrib><creatorcontrib>QING SU</creatorcontrib><creatorcontrib>GAO, Guan-Qi</creatorcontrib><creatorcontrib>PENG, Yong-De</creatorcontrib><creatorcontrib>ZHAO, Jia-Jun</creatorcontrib><creatorcontrib>GUANG NING</creatorcontrib><creatorcontrib>ZHU CHEN</creatorcontrib><creatorcontrib>CHEN, Jia-Lun</creatorcontrib><creatorcontrib>CHEN, Sai-Juan</creatorcontrib><creatorcontrib>WEI HUANG</creatorcontrib><creatorcontrib>SONG, Huai-Dong</creatorcontrib><creatorcontrib>ZHANG, Xiao-Mei</creatorcontrib><creatorcontrib>YUAN, Guo-Yue</creatorcontrib><creatorcontrib>LI, Chang-Gui</creatorcontrib><creatorcontrib>XUE, Li-Qiong</creatorcontrib><creatorcontrib>MIN SHEN</creatorcontrib><creatorcontrib>China Consortium for Genetics of Autoimmune Thyroid Disease</creatorcontrib><creatorcontrib>The China Consortium for the Genetics of Autoimmune Thyroid Disease</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Nature genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>XUN CHU</au><au>PAN, Chun-Ming</au><au>WEI LIU</au><au>FANG XIE</au><au>YANG, Shao-Ying</au><au>WANG, Hai-Feng</au><au>SHI, Jing-Yi</au><au>SUN, Wei-Wei</au><au>DU, Wen-Hua</au><au>ZUO, Chun-Lin</au><au>SHI, Jin-Xiu</au><au>LIU, Bing-Li</au><au>ZHAO, Shuang-Xia</au><au>GUO, Cui-Cui</au><au>MING ZHAN</au><au>GU, Zhao-Hui</au><au>ZHANG, Xiao-Na</au><au>FEI SUN</au><au>WANG, Zhi-Quan</au><au>SONG, Zhi-Yi</au><au>ZOU, Cai-Yan</au><au>SUN, Wei-Hua</au><au>TING GUO</au><au>JUN LIANG</au><au>CAO, Huang-Ming</au><au>MA, Jun-Hua</au><au>BING HAN</au><au>PING LI</au><au>HE JIANG</au><au>HUANG, Qiu-Hua</au><au>LIMING LIANG</au><au>LIU, Li-Bin</au><au>GANG CHEN</au><au>QING SU</au><au>GAO, Guan-Qi</au><au>PENG, Yong-De</au><au>ZHAO, Jia-Jun</au><au>GUANG NING</au><au>ZHU CHEN</au><au>CHEN, Jia-Lun</au><au>CHEN, Sai-Juan</au><au>WEI HUANG</au><au>SONG, Huai-Dong</au><au>ZHANG, Xiao-Mei</au><au>YUAN, Guo-Yue</au><au>LI, Chang-Gui</au><au>XUE, Li-Qiong</au><au>MIN SHEN</au><aucorp>China Consortium for Genetics of Autoimmune Thyroid Disease</aucorp><aucorp>The China Consortium for the Genetics of Autoimmune Thyroid Disease</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A genome-wide association study identifies two new risk loci for Graves' disease</atitle><jtitle>Nature genetics</jtitle><stitle>Nat Genet</stitle><addtitle>Nat Genet</addtitle><date>2011-09-01</date><risdate>2011</risdate><volume>43</volume><issue>9</issue><spage>897</spage><epage>901</epage><pages>897-901</pages><issn>1061-4036</issn><eissn>1546-1718</eissn><coden>NGENEC</coden><abstract>Huai-Dong Song and colleagues report results of a genome-wide association study of Graves' disease. They confirm four previously reported risk loci for this disease and identify two new susceptibility loci at 4p14 and 6q27.
Graves' disease is a common autoimmune disorder characterized by thyroid stimulating hormone receptor autoantibodies (TRAb) and hyperthyroidism. To investigate the genetic architecture of Graves' disease, we conducted a genome-wide association study in 1,536 individuals with Graves' disease (cases) and 1,516 controls. We further evaluated a group of associated SNPs in a second set of 3,994 cases and 3,510 controls. We confirmed four previously reported loci (in the major histocompatibility complex,
TSHR
,
CTLA4
and
FCRL3
) and identified two new susceptibility loci (the
RNASET2-FGFR1OP-CCR6
region at 6q27 (
P
combined
= 6.85 × 10
−10
for rs9355610) and an intergenic region at 4p14 (
P
combined
= 1.08 × 10
−13
for rs6832151)). These newly associated SNPs were correlated with the expression levels of
RNASET2
at 6q27, of
CHRNA9
and of a previously uncharacterized gene at 4p14, respectively. Moreover, we identified strong associations of
TSHR
and major histocompatibility complex class II variants with persistently TRAb-positive Graves' disease.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><pmid>21841780</pmid><doi>10.1038/ng.898</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1061-4036 |
| ispartof | Nature genetics, 2011-09, Vol.43 (9), p.897-901 |
| issn | 1061-4036 1546-1718 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_896834276 |
| source | MEDLINE; Springer Nature - Complete Springer Journals; Nature |
| subjects | 631/208/205/2138 631/208/727/2000 692/308/2779/174 692/699/249/1313 Agriculture Animal Genetics and Genomics Autoantibodies - blood Biological and medical sciences Biomedical and Life Sciences Biomedicine Cancer Research Classical genetics, quantitative genetics, hybrids Disease Endocrinopathies Female Fundamental and applied biological sciences. Psychology Gene expression Gene Function Genetic aspects Genetic Loci Genetic Predisposition to Disease Genetics of eukaryotes. Biological and molecular evolution Genome-Wide Association Study Genomes Graves Disease - epidemiology Graves Disease - genetics Graves Disease - immunology Graves' disease Histocompatibility Antigens Class II - genetics Human Human Genetics Humans letter Male Medical sciences Molecular Sequence Data Non tumoral diseases. Target tissue resistance. Benign neoplasms Physiological aspects Polymerase chain reaction Principal components analysis Quality control Receptors, Thyrotropin - genetics Receptors, Thyrotropin - immunology Regression analysis Risk Risk factors Thyroid Thyroid. Thyroid axis (diseases) |
| title | A genome-wide association study identifies two new risk loci for Graves' disease |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-01T17%3A58%3A39IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=A%20genome-wide%20association%20study%20identifies%20two%20new%20risk%20loci%20for%20Graves'%20disease&rft.jtitle=Nature%20genetics&rft.au=XUN%20CHU&rft.aucorp=China%20Consortium%20for%20Genetics%20of%20Autoimmune%20Thyroid%20Disease&rft.date=2011-09-01&rft.volume=43&rft.issue=9&rft.spage=897&rft.epage=901&rft.pages=897-901&rft.issn=1061-4036&rft.eissn=1546-1718&rft.coden=NGENEC&rft_id=info:doi/10.1038/ng.898&rft_dat=%3Cgale_proqu%3EA267422212%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=894124263&rft_id=info:pmid/21841780&rft_galeid=A267422212&rfr_iscdi=true |