Altered osteogenic commitment of human mesenchymal stem cells by ERM protein-dependent modulation of cellular biomechanics

Abstract Cellular mechanics is known to play an important role in many cellular functions including adhesion, migration, proliferation, and differentiation. Human mesenchymal stem cells (hMSCs) demonstrate unique mechanical properties distinct from fully differentiated cells. This observation sugges...

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Veröffentlicht in:	Journal of biomechanics 2011-10, Vol.44 (15), p.2692-2698
Hauptverfasser:	Titushkin, Igor, Cho, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin AFM Antigens, Differentiation - metabolism Biological and medical sciences Biotechnology Cell Differentiation - physiology Cell Membrane - genetics Cell Membrane - metabolism Cell Membrane - ultrastructure Cell physiology Cells, Cultured Cytoskeletal Proteins - genetics Cytoskeletal Proteins - metabolism Cytoskeleton ERM proteins Fundamental and applied biological sciences. Psychology Gene Silencing Humans LOT Membrane Proteins - genetics Membrane Proteins - metabolism Mesenchymal Stromal Cells - metabolism Mesenchymal Stromal Cells - ultrastructure Microfilament Proteins - genetics Microfilament Proteins - metabolism Microscopy, Atomic Force Molecular and cellular biology Osteogenesis - physiology Physical Medicine and Rehabilitation Proteins SiRNA Stem cell biomechanics Stem cells Stress Fibers - genetics Stress Fibers - metabolism Stress Fibers - ultrastructure
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