Not a surgical vaccine: there is no case for boosting infant male circumcision to combat heterosexual transmission of HIV in Australia
To conduct a critical review of recent proposals that widespread circumcision of male infants be introduced in Australia as a means of combating heterosexually transmitted HIV infection. These arguments are evaluated in terms of their logic, coherence and fidelity to the principles of evidence‐based...
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Veröffentlicht in: | Australian and New Zealand journal of public health 2011-10, Vol.35 (5), p.459-465 |
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description | To conduct a critical review of recent proposals that widespread circumcision of male infants be introduced in Australia as a means of combating heterosexually transmitted HIV infection.
These arguments are evaluated in terms of their logic, coherence and fidelity to the principles of evidence‐based medicine; the extent to which they take account of the evidence for circumcision having a protective effect against HIV and the practicality of circumcision as an HIV control strategy; the extent of its applicability to the specifics of Australia's HIV epidemic; the benefits, harms and risks of circumcision; and the associated human rights, bioethical and legal issues.
Our conclusion is that such proposals ignore doubts about the robustness of the evidence from the African random‐controlled trials as to the protective effect of circumcision and the practical value of circumcision as a means of HIV control; misrepresent the nature of Australia's HIV epidemic and exaggerate the relevance of the African random‐controlled trials findings to it; underestimate the risks and harm of circumcision; and ignore questions of medical ethics and human rights. The notion of circumcision as a ‘surgical vaccine’ is criticised as polemical and unscientific.
Circumcision of infants or other minors has no place among HIV control measures in the Australian and New Zealand context; proposals such as these should be rejected. |
doi_str_mv | 10.1111/j.1753-6405.2011.00761.x |
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These arguments are evaluated in terms of their logic, coherence and fidelity to the principles of evidence‐based medicine; the extent to which they take account of the evidence for circumcision having a protective effect against HIV and the practicality of circumcision as an HIV control strategy; the extent of its applicability to the specifics of Australia's HIV epidemic; the benefits, harms and risks of circumcision; and the associated human rights, bioethical and legal issues.
Our conclusion is that such proposals ignore doubts about the robustness of the evidence from the African random‐controlled trials as to the protective effect of circumcision and the practical value of circumcision as a means of HIV control; misrepresent the nature of Australia's HIV epidemic and exaggerate the relevance of the African random‐controlled trials findings to it; underestimate the risks and harm of circumcision; and ignore questions of medical ethics and human rights. The notion of circumcision as a ‘surgical vaccine’ is criticised as polemical and unscientific.
Circumcision of infants or other minors has no place among HIV control measures in the Australian and New Zealand context; proposals such as these should be rejected.</description><identifier>ISSN: 1326-0200</identifier><identifier>EISSN: 1753-6405</identifier><identifier>DOI: 10.1111/j.1753-6405.2011.00761.x</identifier><identifier>PMID: 21973253</identifier><language>eng</language><publisher>Oxford, UK: Elsevier B.V</publisher><subject>Acquired immune deficiency syndrome ; AIDS ; Australia ; children ; Circumcision ; Circumcision, Male ; Disease prevention ; Disease transmission ; Epidemics ; Epidemiology ; Evidence-Based Medicine ; Hepatitis ; Heterosexuality ; HIV ; HIV Infections - prevention & control ; HIV Infections - transmission ; Human immunodeficiency virus ; Human rights ; Humans ; Immune system ; Immunization ; Infants ; Infections ; Legal issues ; Lentivirus ; Male ; Males ; Medical ethics ; Proposals ; Public health ; random clinical trials ; Randomized Controlled Trials as Topic ; Retroviridae ; Sexual health ; Sexually transmitted diseases ; Sexually Transmitted Diseases - prevention & control ; Sexually Transmitted Diseases - transmission ; STD ; STIs ; sub-Saharan Africa ; Systematic review ; Vaccines</subject><ispartof>Australian and New Zealand journal of public health, 2011-10, Vol.35 (5), p.459-465</ispartof><rights>2011 Copyright 2011 THE AUTHORS.</rights><rights>2011 The Authors. ANZJPH © 2011 Public Health Association of Australia</rights><rights>2011 The Authors. ANZJPH © 2011 Public Health Association of Australia.</rights><rights>2011. This work is published under https://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c6031-f226667a44697a52b786b8a8e56e4ecd173e4101179d85de74353e69989de1fc3</citedby><cites>FETCH-LOGICAL-c6031-f226667a44697a52b786b8a8e56e4ecd173e4101179d85de74353e69989de1fc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1753-6405.2011.00761.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1753-6405.2011.00761.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27866,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21973253$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Darby, Robert</creatorcontrib><creatorcontrib>Van Howe, Robert</creatorcontrib><title>Not a surgical vaccine: there is no case for boosting infant male circumcision to combat heterosexual transmission of HIV in Australia</title><title>Australian and New Zealand journal of public health</title><addtitle>Aust N Z J Public Health</addtitle><description>To conduct a critical review of recent proposals that widespread circumcision of male infants be introduced in Australia as a means of combating heterosexually transmitted HIV infection.
These arguments are evaluated in terms of their logic, coherence and fidelity to the principles of evidence‐based medicine; the extent to which they take account of the evidence for circumcision having a protective effect against HIV and the practicality of circumcision as an HIV control strategy; the extent of its applicability to the specifics of Australia's HIV epidemic; the benefits, harms and risks of circumcision; and the associated human rights, bioethical and legal issues.
Our conclusion is that such proposals ignore doubts about the robustness of the evidence from the African random‐controlled trials as to the protective effect of circumcision and the practical value of circumcision as a means of HIV control; misrepresent the nature of Australia's HIV epidemic and exaggerate the relevance of the African random‐controlled trials findings to it; underestimate the risks and harm of circumcision; and ignore questions of medical ethics and human rights. The notion of circumcision as a ‘surgical vaccine’ is criticised as polemical and unscientific.
Circumcision of infants or other minors has no place among HIV control measures in the Australian and New Zealand context; proposals such as these should be rejected.</description><subject>Acquired immune deficiency syndrome</subject><subject>AIDS</subject><subject>Australia</subject><subject>children</subject><subject>Circumcision</subject><subject>Circumcision, Male</subject><subject>Disease prevention</subject><subject>Disease transmission</subject><subject>Epidemics</subject><subject>Epidemiology</subject><subject>Evidence-Based Medicine</subject><subject>Hepatitis</subject><subject>Heterosexuality</subject><subject>HIV</subject><subject>HIV Infections - prevention & control</subject><subject>HIV Infections - transmission</subject><subject>Human immunodeficiency virus</subject><subject>Human rights</subject><subject>Humans</subject><subject>Immune system</subject><subject>Immunization</subject><subject>Infants</subject><subject>Infections</subject><subject>Legal issues</subject><subject>Lentivirus</subject><subject>Male</subject><subject>Males</subject><subject>Medical ethics</subject><subject>Proposals</subject><subject>Public health</subject><subject>random clinical trials</subject><subject>Randomized Controlled Trials as Topic</subject><subject>Retroviridae</subject><subject>Sexual health</subject><subject>Sexually transmitted diseases</subject><subject>Sexually Transmitted Diseases - prevention & control</subject><subject>Sexually Transmitted Diseases - transmission</subject><subject>STD</subject><subject>STIs</subject><subject>sub-Saharan Africa</subject><subject>Systematic review</subject><subject>Vaccines</subject><issn>1326-0200</issn><issn>1753-6405</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>7TQ</sourceid><recordid>eNqNkc1u1DAUhSMEomXgFZAlFrBJsOPEdpBYTAt0KkUFxJ_ExvI4N62HxC62U6YvwHPjacosWADe-Er3O-f6-mQZIrgg6TzfFITXNGcVrosSE1JgzBkptneyw33jbqppyXJcYnyQPQhhg3FCaXk_OyhJw2lZ08Ps55mLSKEw-XOj1YCulNbGwgsUL8ADMgFZh7QKgHrn0dq5EI09R8b2ykY0qgGQNl5PozbBOItiot24VhFdQATvAmynZBu9smE04YZxPVqdfk4eaDmF1BmMepjd69UQ4NHtvcg-vXn98XiVt29PTo-Xba4ZpiTvy5IxxlVVsYarulxzwdZCCagZVKA7wilUJG3Jm07UHfCK1hRY04imA9Jrusiezr6X3n2fIESZHqVhGJQFNwUpGiYoKZNqkT37K0lEQwRjVYUT-uQPdOMmb9MekmLGMG7qmiVKzJROvxI89PLSm1H5a0mw3KUqN3IXntyFJ3epyptU5TZJH98OmNYjdHvh7xgT8HIGfpgBrv_bWC6_vlulKunzWW9ChO1er_w3yTjltfxydiI_4LZ9L6pWvkr80cxDyurKgJdBG7AaOuNBR9k58--tfgHrrNQx</recordid><startdate>201110</startdate><enddate>201110</enddate><creator>Darby, Robert</creator><creator>Van Howe, Robert</creator><general>Elsevier B.V</general><general>Blackwell Publishing Ltd</general><general>Elsevier Limited</general><scope>6I.</scope><scope>AAFTH</scope><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7T2</scope><scope>7TQ</scope><scope>C1K</scope><scope>DHY</scope><scope>DON</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7U2</scope><scope>7X8</scope></search><sort><creationdate>201110</creationdate><title>Not a surgical vaccine: there is no case for boosting infant male circumcision to combat heterosexual transmission of HIV in Australia</title><author>Darby, Robert ; Van Howe, Robert</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c6031-f226667a44697a52b786b8a8e56e4ecd173e4101179d85de74353e69989de1fc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Acquired immune deficiency syndrome</topic><topic>AIDS</topic><topic>Australia</topic><topic>children</topic><topic>Circumcision</topic><topic>Circumcision, Male</topic><topic>Disease prevention</topic><topic>Disease transmission</topic><topic>Epidemics</topic><topic>Epidemiology</topic><topic>Evidence-Based Medicine</topic><topic>Hepatitis</topic><topic>Heterosexuality</topic><topic>HIV</topic><topic>HIV Infections - prevention & control</topic><topic>HIV Infections - transmission</topic><topic>Human immunodeficiency virus</topic><topic>Human rights</topic><topic>Humans</topic><topic>Immune system</topic><topic>Immunization</topic><topic>Infants</topic><topic>Infections</topic><topic>Legal issues</topic><topic>Lentivirus</topic><topic>Male</topic><topic>Males</topic><topic>Medical ethics</topic><topic>Proposals</topic><topic>Public health</topic><topic>random clinical trials</topic><topic>Randomized Controlled Trials as Topic</topic><topic>Retroviridae</topic><topic>Sexual health</topic><topic>Sexually transmitted diseases</topic><topic>Sexually Transmitted Diseases - prevention & control</topic><topic>Sexually Transmitted Diseases - transmission</topic><topic>STD</topic><topic>STIs</topic><topic>sub-Saharan Africa</topic><topic>Systematic review</topic><topic>Vaccines</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Darby, Robert</creatorcontrib><creatorcontrib>Van Howe, Robert</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>PAIS Index</collection><collection>Environmental Sciences and Pollution Management</collection><collection>PAIS International</collection><collection>PAIS International (Ovid)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Safety Science and Risk</collection><collection>MEDLINE - Academic</collection><jtitle>Australian and New Zealand journal of public health</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Darby, Robert</au><au>Van Howe, Robert</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Not a surgical vaccine: there is no case for boosting infant male circumcision to combat heterosexual transmission of HIV in Australia</atitle><jtitle>Australian and New Zealand journal of public health</jtitle><addtitle>Aust N Z J Public Health</addtitle><date>2011-10</date><risdate>2011</risdate><volume>35</volume><issue>5</issue><spage>459</spage><epage>465</epage><pages>459-465</pages><issn>1326-0200</issn><eissn>1753-6405</eissn><abstract>To conduct a critical review of recent proposals that widespread circumcision of male infants be introduced in Australia as a means of combating heterosexually transmitted HIV infection.
These arguments are evaluated in terms of their logic, coherence and fidelity to the principles of evidence‐based medicine; the extent to which they take account of the evidence for circumcision having a protective effect against HIV and the practicality of circumcision as an HIV control strategy; the extent of its applicability to the specifics of Australia's HIV epidemic; the benefits, harms and risks of circumcision; and the associated human rights, bioethical and legal issues.
Our conclusion is that such proposals ignore doubts about the robustness of the evidence from the African random‐controlled trials as to the protective effect of circumcision and the practical value of circumcision as a means of HIV control; misrepresent the nature of Australia's HIV epidemic and exaggerate the relevance of the African random‐controlled trials findings to it; underestimate the risks and harm of circumcision; and ignore questions of medical ethics and human rights. The notion of circumcision as a ‘surgical vaccine’ is criticised as polemical and unscientific.
Circumcision of infants or other minors has no place among HIV control measures in the Australian and New Zealand context; proposals such as these should be rejected.</abstract><cop>Oxford, UK</cop><pub>Elsevier B.V</pub><pmid>21973253</pmid><doi>10.1111/j.1753-6405.2011.00761.x</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Acquired immune deficiency syndrome AIDS Australia children Circumcision Circumcision, Male Disease prevention Disease transmission Epidemics Epidemiology Evidence-Based Medicine Hepatitis Heterosexuality HIV HIV Infections - prevention & control HIV Infections - transmission Human immunodeficiency virus Human rights Humans Immune system Immunization Infants Infections Legal issues Lentivirus Male Males Medical ethics Proposals Public health random clinical trials Randomized Controlled Trials as Topic Retroviridae Sexual health Sexually transmitted diseases Sexually Transmitted Diseases - prevention & control Sexually Transmitted Diseases - transmission STD STIs sub-Saharan Africa Systematic review Vaccines |
title | Not a surgical vaccine: there is no case for boosting infant male circumcision to combat heterosexual transmission of HIV in Australia |
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