Increases in Blood Pressure and Heart Rate Induced by Caffeine are Inhibited by (−)-Epigallocatechin-3-O-gallate: Involvement of Catecholamines
In a previous experiment, (−)-epigallocatechin-3-O-gallate (EGCG) reduced caffeine-induced locomotor activity and stereotyped behaviors and inhibited caffeine-induced neuronal stimulant activity. This research was performed to give additional evidence that EGCG counteracts caffeine-induced stimulant...
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| Veröffentlicht in: | Journal of cardiovascular pharmacology 2011-10, Vol.58 (4), p.446-449 |
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| container_title | Journal of cardiovascular pharmacology |
| container_volume | 58 |
| creator | Han, Jin-Yi Kim, Chung-Soo Lim, Kyu-Hee Kim, Jong-Hoon Kim, Seunghwan Yun, Yeo-Pyo Hong, Jin Tae Oh, Ki-Wan |
| description | In a previous experiment, (−)-epigallocatechin-3-O-gallate (EGCG) reduced caffeine-induced locomotor activity and stereotyped behaviors and inhibited caffeine-induced neuronal stimulant activity. This research was performed to give additional evidence that EGCG counteracts caffeine-induced stimulant effects in animals. EGCG inhibited caffeine-induced cardiovascular activation measures, such as arterial pressure and heart rate. In addition, the increases in the levels of adrenaline and noradrenaline in the blood induced by caffeine was reduced by EGCG. We suggest that EGCG may reduce caffeine-induced increases in blood pressure and heart rate and may decrease the levels of catecholamines in the blood. Therefore, EGCG counteracts caffeine-induced cardiovascular activity. The stimulant effects of caffeine should be reduced by the amount of EGCG in green tea. |
| doi_str_mv | 10.1097/FJC.0B013E31822D93CB |
| format | Article |
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This research was performed to give additional evidence that EGCG counteracts caffeine-induced stimulant effects in animals. EGCG inhibited caffeine-induced cardiovascular activation measures, such as arterial pressure and heart rate. In addition, the increases in the levels of adrenaline and noradrenaline in the blood induced by caffeine was reduced by EGCG. We suggest that EGCG may reduce caffeine-induced increases in blood pressure and heart rate and may decrease the levels of catecholamines in the blood. Therefore, EGCG counteracts caffeine-induced cardiovascular activity. The stimulant effects of caffeine should be reduced by the amount of EGCG in green tea.</description><identifier>ISSN: 0160-2446</identifier><identifier>EISSN: 1533-4023</identifier><identifier>DOI: 10.1097/FJC.0B013E31822D93CB</identifier><identifier>PMID: 21975870</identifier><language>eng</language><publisher>United States: Lippincott Williams & Wilkins, Inc</publisher><subject>Animals ; Blood Pressure - drug effects ; Caffeine - pharmacology ; Catechin - analogs & derivatives ; Catechin - pharmacology ; Epinephrine - blood ; Heart Rate - drug effects ; Male ; Norepinephrine - blood ; Rats ; Rats, Wistar</subject><ispartof>Journal of cardiovascular pharmacology, 2011-10, Vol.58 (4), p.446-449</ispartof><rights>2011 Lippincott Williams & Wilkins, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5377-278123fc86abb6f88e6f9a6d2835a830b8fef7d4c1508a26c852dc5fed7ebbf63</citedby><cites>FETCH-LOGICAL-c5377-278123fc86abb6f88e6f9a6d2835a830b8fef7d4c1508a26c852dc5fed7ebbf63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21975870$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Han, Jin-Yi</creatorcontrib><creatorcontrib>Kim, Chung-Soo</creatorcontrib><creatorcontrib>Lim, Kyu-Hee</creatorcontrib><creatorcontrib>Kim, Jong-Hoon</creatorcontrib><creatorcontrib>Kim, Seunghwan</creatorcontrib><creatorcontrib>Yun, Yeo-Pyo</creatorcontrib><creatorcontrib>Hong, Jin Tae</creatorcontrib><creatorcontrib>Oh, Ki-Wan</creatorcontrib><title>Increases in Blood Pressure and Heart Rate Induced by Caffeine are Inhibited by (−)-Epigallocatechin-3-O-gallate: Involvement of Catecholamines</title><title>Journal of cardiovascular pharmacology</title><addtitle>J Cardiovasc Pharmacol</addtitle><description>In a previous experiment, (−)-epigallocatechin-3-O-gallate (EGCG) reduced caffeine-induced locomotor activity and stereotyped behaviors and inhibited caffeine-induced neuronal stimulant activity. This research was performed to give additional evidence that EGCG counteracts caffeine-induced stimulant effects in animals. EGCG inhibited caffeine-induced cardiovascular activation measures, such as arterial pressure and heart rate. In addition, the increases in the levels of adrenaline and noradrenaline in the blood induced by caffeine was reduced by EGCG. We suggest that EGCG may reduce caffeine-induced increases in blood pressure and heart rate and may decrease the levels of catecholamines in the blood. Therefore, EGCG counteracts caffeine-induced cardiovascular activity. The stimulant effects of caffeine should be reduced by the amount of EGCG in green tea.</description><subject>Animals</subject><subject>Blood Pressure - drug effects</subject><subject>Caffeine - pharmacology</subject><subject>Catechin - analogs & derivatives</subject><subject>Catechin - pharmacology</subject><subject>Epinephrine - blood</subject><subject>Heart Rate - drug effects</subject><subject>Male</subject><subject>Norepinephrine - blood</subject><subject>Rats</subject><subject>Rats, Wistar</subject><issn>0160-2446</issn><issn>1533-4023</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFUdtu1DAQtRCIbgt_gFDegAcXXxLb4Y0NW7qoUhGC58iXMRtI4q2dtOof9BU-kS_BYQtYGlkzc86Z0RyEnlFySkktX599aE7JmlC-4VQx9q7mzfoBWtGKc1wSxh-iFaGCYFaW4ggdp_SNEFpWUjxGR4zWslKSrNCP7Wgj6ASp6MZi3Yfgio8RUpojFHp0xTnoOBWf9ATFdnSzBVeY26LR3kM3Zkhc6rvOdNOh8_LX3c9XeLPvvuq-Dzbz7K4bMceXeKnk_E0mXIf-GgYYpyL4LLaAQq-HrJieoEde9wme3v8n6MvZ5nNzji8u32-btxfYVlxKzKSijHurhDZGeKVA-FoLxxSvtOLEKA9eutLSiijNhFUVc7by4CQY4wU_QS8OuvsYrmZIUzt0yUJecYQwp1bVQjEpFM_I8oC0MaQUwbf72A063raUtIsXbfaiJSZ7AX-8cDW3JtOe3w-YzQDuH-nv8f_r3oR-gpi-9_MNxHYHup92Lcmv4mWJGaGULhnOQSX_DQcTl2M</recordid><startdate>201110</startdate><enddate>201110</enddate><creator>Han, Jin-Yi</creator><creator>Kim, Chung-Soo</creator><creator>Lim, Kyu-Hee</creator><creator>Kim, Jong-Hoon</creator><creator>Kim, Seunghwan</creator><creator>Yun, Yeo-Pyo</creator><creator>Hong, Jin Tae</creator><creator>Oh, Ki-Wan</creator><general>Lippincott Williams & Wilkins, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201110</creationdate><title>Increases in Blood Pressure and Heart Rate Induced by Caffeine are Inhibited by (−)-Epigallocatechin-3-O-gallate: Involvement of Catecholamines</title><author>Han, Jin-Yi ; Kim, Chung-Soo ; Lim, Kyu-Hee ; Kim, Jong-Hoon ; Kim, Seunghwan ; Yun, Yeo-Pyo ; Hong, Jin Tae ; Oh, Ki-Wan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5377-278123fc86abb6f88e6f9a6d2835a830b8fef7d4c1508a26c852dc5fed7ebbf63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Animals</topic><topic>Blood Pressure - drug effects</topic><topic>Caffeine - pharmacology</topic><topic>Catechin - analogs & derivatives</topic><topic>Catechin - pharmacology</topic><topic>Epinephrine - blood</topic><topic>Heart Rate - drug effects</topic><topic>Male</topic><topic>Norepinephrine - blood</topic><topic>Rats</topic><topic>Rats, Wistar</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Han, Jin-Yi</creatorcontrib><creatorcontrib>Kim, Chung-Soo</creatorcontrib><creatorcontrib>Lim, Kyu-Hee</creatorcontrib><creatorcontrib>Kim, Jong-Hoon</creatorcontrib><creatorcontrib>Kim, Seunghwan</creatorcontrib><creatorcontrib>Yun, Yeo-Pyo</creatorcontrib><creatorcontrib>Hong, Jin Tae</creatorcontrib><creatorcontrib>Oh, Ki-Wan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of cardiovascular pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Han, Jin-Yi</au><au>Kim, Chung-Soo</au><au>Lim, Kyu-Hee</au><au>Kim, Jong-Hoon</au><au>Kim, Seunghwan</au><au>Yun, Yeo-Pyo</au><au>Hong, Jin Tae</au><au>Oh, Ki-Wan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Increases in Blood Pressure and Heart Rate Induced by Caffeine are Inhibited by (−)-Epigallocatechin-3-O-gallate: Involvement of Catecholamines</atitle><jtitle>Journal of cardiovascular pharmacology</jtitle><addtitle>J Cardiovasc Pharmacol</addtitle><date>2011-10</date><risdate>2011</risdate><volume>58</volume><issue>4</issue><spage>446</spage><epage>449</epage><pages>446-449</pages><issn>0160-2446</issn><eissn>1533-4023</eissn><abstract>In a previous experiment, (−)-epigallocatechin-3-O-gallate (EGCG) reduced caffeine-induced locomotor activity and stereotyped behaviors and inhibited caffeine-induced neuronal stimulant activity. 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| ispartof | Journal of cardiovascular pharmacology, 2011-10, Vol.58 (4), p.446-449 |
| issn | 0160-2446 1533-4023 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Journals@Ovid Complete |
| subjects | Animals Blood Pressure - drug effects Caffeine - pharmacology Catechin - analogs & derivatives Catechin - pharmacology Epinephrine - blood Heart Rate - drug effects Male Norepinephrine - blood Rats Rats, Wistar |
| title | Increases in Blood Pressure and Heart Rate Induced by Caffeine are Inhibited by (−)-Epigallocatechin-3-O-gallate: Involvement of Catecholamines |
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