PREPARE trial: a randomized phase III trial comparing preoperative, dose-dense, dose-intensified chemotherapy with epirubicin, paclitaxel, and CMF versus a standard-dosed epirubicin–cyclophosphamide followed by paclitaxel with or without darbepoetin alfa in primary breast cancer—outcome on prognosis

The objective of this study was to compare the effect of dose-intensified neoadjuvant chemotherapy with that of standard epirubicin plus cyclophosphamide followed by paclitaxel in combination with or without darbepoetin on survival in primary breast cancer. A total of 733 patients received either fo...

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Veröffentlicht in:	Annals of oncology 2011-09, Vol.22 (9), p.1999-2006
Hauptverfasser:	Untch, M., von Minckwitz, G., Konecny, G.E., Conrad, U., Fett, W., Kurzeder, C., Lück, H.-J., Stickeler, E., Urbaczyk, H., Liedtke, B., Beckmann, M.W., Salat, C., Harbeck, N., Müller, V., Schmidt, M., Hasmüller, S., Lenhard, M., Nekljudova, V., Lebeau, A., Loibl, S., Fasching, P.A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Anemia - drug therapy Antineoplastic agents Antineoplastic Combined Chemotherapy Protocols - administration & dosage Antineoplastic Combined Chemotherapy Protocols - adverse effects Biological and medical sciences Breast Neoplasms - blood Breast Neoplasms - drug therapy Breast Neoplasms - surgery Chemotherapy, Adjuvant Cyclophosphamide - administration & dosage Cyclophosphamide - adverse effects Darbepoetin alfa Disease-Free Survival Dose-Response Relationship, Drug Epirubicin - administration & dosage Epirubicin - adverse effects Erythropoietin - administration & dosage Erythropoietin - analogs & derivatives Female Fluorouracil - administration & dosage Fluorouracil - adverse effects Gynecology. Andrology. Obstetrics Humans Mammary gland diseases Medical sciences Methotrexate - administration & dosage Methotrexate - adverse effects Middle Aged Multivariate Analysis neoadjuvant dose-dense chemotherapy neoadjuvant dose-intensified therapy Neoadjuvant Therapy Paclitaxel - administration & dosage Paclitaxel - adverse effects Patient Compliance Pharmacology. Drug treatments Preoperative Care primary breast cancer Treatment Outcome Tumors Young Adult
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