Curcumin reverses chemoresistance of human gastric cancer cells by downregulating the NF-κB transcription factor

Gastric cancer remains one of the major health problems worldwide. Chemotherapy is an important therapeutic modality for gastric cancer, but the success rate of this treatment is limited because of chemoresistance. The ubiquitously expressed transcription factor NF-κB has been suggested to be associ...

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Veröffentlicht in:	Oncology reports 2011-11, Vol.26 (5), p.1197-1203
Hauptverfasser:	YU, Liang-Liang, WU, Jia-Guo, NING DAI, YU, Hong-Gang, SI, Jian-Min
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Combined Chemotherapy Protocols - pharmacology Apoptosis - drug effects bcl-X Protein - metabolism Biological and medical sciences Cell Growth Processes - drug effects Cell Line, Tumor Curcumin - administration & dosage Curcumin - pharmacology DNA, Neoplasm - metabolism Down-Regulation - drug effects Doxorubicin - administration & dosage Doxorubicin - pharmacology Drug Resistance, Neoplasm Drug Synergism Etoposide - administration & dosage Etoposide - pharmacology Gastroenterology. Liver. Pancreas. Abdomen Humans I-kappa B Proteins - metabolism Immunohistochemistry In Situ Nick-End Labeling Medical sciences NF-kappa B - biosynthesis NF-kappa B - genetics NF-kappa B - metabolism NF-KappaB Inhibitor alpha Phosphorylation - drug effects Proto-Oncogene Proteins c-bcl-2 - metabolism Stomach Neoplasms - drug therapy Stomach Neoplasms - genetics Stomach Neoplasms - pathology Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Transcription Factor RelA - biosynthesis Transcription Factor RelA - genetics Tumors
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