Hepatocyte entry leads to degradation of autoreactive CD8 T cells

Although most self-reactive T cells are eliminated in the thymus, mechanisms to inactivate or control T cells specific for extrathymic antigens are required and exist in the periphery. By investigating the site in which autoreactive T cells are tolerized, we identify a unique mechanism of peripheral...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2011-10, Vol.108 (40), p.16735-16740
Hauptverfasser:	Benseler, Volker, Warren, Alessandra, Vo, Michelle, Holz, Lauren E, Tay, Szun S, Le Couteur, David G, Breen, Eamon, Allison, Anthony C, van Rooijen, Nico, McGuffog, Claire, Schlitt, Hans J, Bowen, David G, McCaughan, Geoffrey W, Bertolino, Patrick
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies Antigens Apoptosis Regulatory Proteins - genetics Autoimmune diseases autoimmune hepatitis Bcl-2-Like Protein 11 Biological Sciences CD8 antigen CD8-Positive T-Lymphocytes - immunology Cell activation Cell Death - immunology cell invasion Cells Emperipolesis Emperipolesis - immunology Hepatitis Hepatocytes Hepatocytes - immunology Homeodomain Proteins - genetics Immunological tolerance Liver Lymphocytes T Membrane Proteins - genetics Mice Mice, Knockout Microscopy, Confocal Microscopy, Electron Natural killer cells Natural killer T cells Peripheral Tolerance - immunology Physiology Proto-Oncogene Proteins - genetics T cell receptors T lymphocytes Thymus Tumor cell line
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