KRAS Mutation in Metastatic Pancreatic Ductal Adenocarcinoma: Results of a Multicenter Phase II Study Evaluating Efficacy of Cetuximab plus Gemcitabine/Oxaliplatin (GEMOXCET) in First-Line Therapy

Background: Genetic alterations within the epidermal growth factor receptor (EGFR) pathway, including KRAS mutations, have been demonstrated to be associated with response to EGFR inhibitors like cetuximab in colorectal cancers. Mutations in the KRAS gene have been found in 70–90% of pancreatic canc...

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Veröffentlicht in:	Oncology 2011-01, Vol.81 (1), p.3-8
Hauptverfasser:	Kullmann, F., Hartmann, A., Stöhr, R., Messmann, H., Dollinger, M.M., Trojan, J., Fuchs, M., Hollerbach, S., Harder, J., Troppmann, M., Kutscheidt, A., Endlicher, E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma Adenocarcinoma - drug therapy Adenocarcinoma - genetics Adenocarcinoma - secondary Adult Aged Antibodies, Monoclonal - administration & dosage Antibodies, Monoclonal, Humanized Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biological and medical sciences Cancer Carcinoma, Pancreatic Ductal - drug therapy Carcinoma, Pancreatic Ductal - genetics Carcinoma, Pancreatic Ductal - secondary Cetuximab Chemotherapy Clinical Study Clinical trials Codons Colorectal cancer Deoxycytidine - administration & dosage Deoxycytidine - analogs & derivatives Drug therapy Epidermal growth factor receptors Exanthema Female Gastroenterology. Liver. Pancreas. Abdomen gemcitabine Humans K-Ras protein Liver Neoplasms - drug therapy Liver Neoplasms - genetics Liver Neoplasms - secondary Liver. Biliary tract. Portal circulation. Exocrine pancreas Lung Neoplasms - drug therapy Lung Neoplasms - genetics Lung Neoplasms - secondary Lymphatic Metastasis Male Medical sciences Metastases Middle Aged Mutation Mutation - genetics Organoplatinum Compounds - administration & dosage oxaliplatin Pancreatic cancer Pancreatic Neoplasms - drug therapy Pancreatic Neoplasms - genetics Pancreatic Neoplasms - pathology Point mutation Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins p21(ras) ras Proteins - genetics Retrospective Studies Statistics Survival Survival Rate Treatment Outcome Tumors
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