Proton Pump Inhibitors Exacerbate NSAID-Induced Small Intestinal Injury by Inducing Dysbiosis

Background & Aims Proton pump inhibitors (PPIs) and nonsteroidal anti-inflammatory drugs (NSAIDs) are among the most commonly used classes of drugs, with the former frequently coprescribed to reduce gastroduodenal injury caused by the latter. However, suppression of gastric acid secretion by PPI...

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Veröffentlicht in:	Gastroenterology (New York, N.Y. 1943) N.Y. 1943), 2011-10, Vol.141 (4), p.1314-1322.e5
Hauptverfasser:	Wallace, John L, Syer, Stephanie, Denou, Emmanuel, de Palma, Giada, Vong, Linda, McKnight, Webb, Jury, Jennifer, Bolla, Manlio, Bercik, Premysl, Collins, Stephen M, Verdu, Elena, Ongini, Ennio
Format:	Artikel
Sprache:	eng
Schlagworte:	2-Pyridinylmethylsulfinylbenzimidazoles - toxicity Acid Secretion Actinobacteria - drug effects Actinobacteria - genetics Actinobacteria - growth & development Actinobacteria - isolation & purification Animals Anti-Inflammatory Agents, Non-Steroidal - pharmacokinetics Anti-Inflammatory Agents, Non-Steroidal - toxicity Bifidobacterium - drug effects Bifidobacterium - genetics Bifidobacterium - growth & development Bifidobacterium - isolation & purification Bleeding Celecoxib Colon - drug effects Colon - microbiology Denaturing Gradient Gel Electrophoresis Disease Models, Animal Drug Interactions Gastroenterology and Hepatology Gastrointestinal Hemorrhage - chemically induced Gastrointestinal Hemorrhage - microbiology Gastrointestinal Hemorrhage - pathology Gastrointestinal Hemorrhage - prevention & control Hematocrit Jejunum - drug effects Jejunum - microbiology Jejunum - pathology Lansoprazole Male Microflora Naproxen - toxicity Omeprazole - toxicity Peptic Ulcer - chemically induced Peptic Ulcer - microbiology Peptic Ulcer - pathology Peptic Ulcer - prevention & control Probiotics - pharmacology Proton Pump Inhibitors - toxicity Pyrazoles - toxicity Rats Rats, Wistar Reverse Transcriptase Polymerase Chain Reaction Sulfonamides - toxicity Time Factors Ulcer
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