Controlled release of chlorhexidine antiseptic from microporous amorphous silica applied in open porosity of an implant surface

Amorphous microporous silica (AMS) serving as a reservoir for controlled release of a bioactive agent was applied in the open porosity of a titanium coating on a Ti–6Al–4V metal substrate. The pores of the AMS emptied by calcination were loaded with chlorhexidine diacetate (CHX) via incipient wetnes...

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Veröffentlicht in:	International journal of pharmaceutics 2011-10, Vol.419 (1), p.28-32
Hauptverfasser:	Verraedt, Els, Braem, Annabel, Chaudhari, Amol, Thevissen, Karin, Adams, Erwin, Van Mellaert, Lieve, Cammue, Bruno P.A., Duyck, Joke, Anné, Jozef, Vleugels, Jef, Martens, Johan A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetates - administration & dosage Acetates - pharmacology AMS coatings Anti-Infective Agents, Local - administration & dosage Anti-Infective Agents, Local - pharmacology Biofilm prevention Biological and medical sciences Candida albicans Candida albicans - drug effects Chlorhexidine Controlled release Delayed-Action Preparations General pharmacology Medical sciences Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Porosity Prostheses and Implants Silicon Dioxide - chemistry Staphylococcus aureus Staphylococcus epidermidis Staphylococcus epidermidis - drug effects Titanium - chemistry
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