Bioavailability and pharmacokinetics of sorafenib suspension, nanoparticles and nanomatrix for oral administration to rat

Sorafenib is slightly absorbed in the gastrointestinal tract due to its poor solubility in water. To improve its absorption, a novel nanoparticulate formulation-nanomatrix was used in the study. The nanomatrix was a system prepared from a porous material Sylysia ® 350 and a pH sensitive polymer Eudr...

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Veröffentlicht in:	International journal of pharmaceutics 2011-10, Vol.419 (1), p.339-346
Hauptverfasser:	Wang, Xue-qing, Fan, Jie-ming, Liu, Ya-ou, Zhao, Bo, Jia, Zeng-rong, Zhang, Qiang
Format:	Artikel
Sprache:	eng
Schlagworte:	absorption Adhesiveness Administration, Oral Animals Antineoplastic Agents - administration & dosage Antineoplastic Agents - pharmacokinetics Area Under Curve Benzenesulfonates - administration & dosage Benzenesulfonates - pharmacokinetics bioavailability Biological and medical sciences Biological Availability drugs gastrointestinal system General pharmacology Hydrogen-Ion Concentration Male Medical sciences Nanomatrix Nanoparticles Nanostructures Niacinamide - analogs & derivatives oral administration Oral bioavailability pH-sensitive nanoparticles Pharmaceutical technology. Pharmaceutical industry pharmacokinetics Pharmacology. Drug treatments Phenylurea Compounds polymers Polymethacrylic Acids - chemistry Porosity Pyridines - administration & dosage Pyridines - pharmacokinetics Rats Rats, Sprague-Dawley Silicon Dioxide - chemistry Solubility Sorafenib Suspension Suspensions water solubility
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