BCL9-2 Promotes Early Stages of Intestinal Tumor Progression

Background & Aims The roles of the 2 BCL9 and 2 Pygopus genes in Wnt to β-catenin signaling are not clear in vertebrates. We examined their expression and function in normal and tumor intestinal epithelia in mice and humans. Methods Specific antibodies were generated to characterize the BCL9 and...

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Veröffentlicht in:	Gastroenterology (New York, N.Y. 1943) N.Y. 1943), 2011-10, Vol.141 (4), p.1359-1370.e3
Hauptverfasser:	Brembeck, Felix H, Wiese, Maria, Zatula, Nathalie, Grigoryan, Tamara, Dai, Yiyang, Fritzmann, Johannes, Birchmeier, Walter
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - metabolism Adenoma - genetics Adenoma - metabolism Adenoma - pathology Animals beta Catenin - metabolism Caco-2 Cells Carcinogenesis Cell Transformation, Neoplastic - genetics Cell Transformation, Neoplastic - metabolism Cell Transformation, Neoplastic - pathology Colon Cancer Colorectal Neoplasms - genetics Colorectal Neoplasms - metabolism Colorectal Neoplasms - pathology DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Gastroenterology and Hepatology Gene Expression Regulation, Neoplastic Genes, APC Genes, Reporter HCT116 Cells HEK293 Cells HT29 Cells Humans Immunohistochemistry Intestinal Neoplasms - genetics Intestinal Neoplasms - metabolism Intestinal Neoplasms - pathology Intestines - metabolism Intestines - pathology Intracellular Signaling Peptides and Proteins - metabolism Keratin-19 - genetics Mice Mice, Inbred C57BL Mice, Transgenic Mouse Model Promoter Regions, Genetic Reverse Transcriptase Polymerase Chain Reaction RNA Interference Signal Transduction Time Factors Tissue Array Analysis Transcription Factors - genetics Transcription Factors - metabolism Transfection Wnt Proteins - metabolism
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