Sauchinone Suppresses Pro-inflammatory Mediators by Inducing Heme Oxygenase-1 in RAW264.7 Macrophages

Sauchinone, a biologically active lignan isolated from the roots of Saururus chinensis (LOUR.) BAILL. (Saururaceae), is reported to exert a variety of biological activities, such as hepatoprotective, anti-inflammatory actions and inhibitory effects on bone resorption. In this study, we investigated...

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Veröffentlicht in:	Biological & pharmaceutical bulletin 2011/10/01, Vol.34(10), pp.1566-1571
Hauptverfasser:	Li, Bin, Lee, Dong-Sung, Choi, Hyun-Gyu, Kim, Kyoung-Su, Kang, Dae-Gil, Lee, Ho-Sub, Jeong, Gil-Saeng, Kim, Youn-Chul
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents - chemistry Anti-Inflammatory Agents - immunology Anti-Inflammatory Agents - metabolism Anti-Inflammatory Agents - pharmacology Benzopyrans - chemistry Benzopyrans - immunology Benzopyrans - metabolism Benzopyrans - pharmacology Cell Line Cyclooxygenase 2 - immunology Cyclooxygenase 2 - metabolism Dioxoles - chemistry Dioxoles - immunology Dioxoles - metabolism Dioxoles - pharmacology Drug Evaluation, Preclinical Enzyme Inhibitors - metabolism Enzyme Inhibitors - pharmacology extracellular signal-regulated kinase phosphorylation Extracellular Signal-Regulated MAP Kinases - drug effects Extracellular Signal-Regulated MAP Kinases - immunology Extracellular Signal-Regulated MAP Kinases - metabolism Flavonoids - metabolism Flavonoids - pharmacology heme oxygenase-1 Heme Oxygenase-1 - immunology Heme Oxygenase-1 - metabolism Inflammation - drug therapy Inflammation - physiopathology Inflammation Mediators - antagonists & inhibitors Inflammation Mediators - immunology Lipopolysaccharides - immunology Lipopolysaccharides - pharmacology Macrophages - drug effects Macrophages - immunology Metalloporphyrins Mice Molecular Targeted Therapy Nitric Oxide - biosynthesis Nitric Oxide - immunology Nitric Oxide Synthase Type II - antagonists & inhibitors Nitric Oxide Synthase Type II - drug effects Phosphorylation - drug effects Phytotherapy Plant Preparations - chemistry Plant Preparations - isolation & purification Plant Preparations - pharmacology Plant Roots pro-inflammatory mediator Protoporphyrins RAW264.7 macrophage sauchinone Saururaceae Saururus Signal Transduction - drug effects Tumor Necrosis Factor-alpha - antagonists & inhibitors Tumor Necrosis Factor-alpha - biosynthesis Tumor Necrosis Factor-alpha - immunology
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