Hepatocellular Carcinoma Cells and Their Fibrotic Microenvironment Modulate Bone Marrow-Derived Mesenchymal Stromal Cell Migration in Vitro and in Vivo

Hepatocellular carcinoma (HCC) is the fifth most common cancer and the third cause of cancer-related death. Fibrogenesis is an active process characterized by the production of several proinflammatory cytokines, chemokines and growth factors. It involves the activation of hepatic stellate cells (HSC...

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Veröffentlicht in:	Molecular pharmaceutics 2011-10, Vol.8 (5), p.1538-1548
Hauptverfasser:	Garcia, Mariana G, Bayo, Juan, Bolontrade, Marcela F, Sganga, Leonardo, Malvicini, Mariana, Alaniz, Laura, Aquino, Jorge B, Fiore, Esteban, Rizzo, Manglio M, Rodriguez, Andrés, Lorenti, Alicia, Andriani, Oscar, Podhajcer, Osvaldo, Mazzolini, Guillermo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bone Marrow Cells - metabolism Bone Marrow Cells - pathology Carcinoma, Hepatocellular - metabolism Carcinoma, Hepatocellular - pathology Carcinoma, Hepatocellular - physiopathology Carcinoma, Hepatocellular - therapy Cell Adhesion Cell Line Cell Line, Tumor Cell Movement Culture Media, Conditioned Endothelium, Vascular - metabolism Hepatic Stellate Cells - metabolism Hepatic Stellate Cells - pathology Humans Liver Cirrhosis - etiology Liver Cirrhosis - metabolism Liver Cirrhosis - pathology Liver Cirrhosis - therapy Liver Neoplasms - metabolism Liver Neoplasms - pathology Liver Neoplasms - physiopathology Liver Neoplasms - therapy Male Matrix Metalloproteinase 2 - metabolism Mesenchymal Stem Cell Transplantation Mesenchymal Stromal Cells - metabolism Mesenchymal Stromal Cells - pathology Mice Mice, Nude Neoplasm Proteins - metabolism Spheroids, Cellular - metabolism Spheroids, Cellular - pathology Tumor Cells, Cultured Tumor Microenvironment Up-Regulation Xenograft Model Antitumor Assays
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