Mechanisms of in-vitro-selected daptomycin-non-susceptibility in Staphylococcus aureus

Abstract Daptomycin is highly active against Staphylococcus aureus , including multidrug-resistant strains and those with reduced susceptibility to vancomycin. However, daptomycin-non-susceptible (DapNS ) strains [minimum inhibitory concentration (MIC) >1 mg/L] have been derived clinically and in...

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Veröffentlicht in:	International journal of antimicrobial agents 2011-11, Vol.38 (5), p.442-446
Hauptverfasser:	Patel, Diixa, Husain, Mashkur, Vidaillac, Celine, Steed, Molly E, Rybak, Michael J, Seo, Susan M, Kaatz, Glenn W
Format:	Artikel
Sprache:	eng
Schlagworte:	amino acid substitution Anti-Bacterial Agents - pharmacology Antibiotics. Antiinfectious agents. Antiparasitic agents autolysis Bacterial diseases Bacterial Proteins - genetics Biological and medical sciences biosynthesis Cell Wall - metabolism cell walls cytochrome c Daptomycin Daptomycin - pharmacology Drug Resistance, Bacterial - genetics gene expression Gene Expression Regulation, Bacterial glycopeptides Human bacterial diseases Humans Infectious Disease Infectious diseases lysostaphin Lysostaphin - pharmacology Medical sciences Microbial Sensitivity Tests minimum inhibitory concentration multiple drug resistance Mutation nisin Pharmacology. Drug treatments Phenotype Polymerase Chain Reaction - methods Resistance Sequence Analysis, DNA Staphylococcal infections, streptococcal infections, pneumococcal infections Staphylococcus aureus Staphylococcus aureus - drug effects Staphylococcus aureus - genetics vancomycin
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