Mechanism of potentiation by tea epigallocatechin of contraction in porcine coronary artery: The role of protein kinase Cδ-mediated CPI-17 phosphorylation

The effects of green tea catechins, (+)- and (−)-catechins (C), (−)-epicatechin (EC), (−)-epicatechin gallate (ECG), (−)-epigallocatechin (EGC), and (−)-epigallocatechin gallate (EGCG), on vascular contractility were investigated in porcine coronary artery. At the concentration of 200 μM, only EGC,...

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Veröffentlicht in:	European journal of pharmacology 2011-10, Vol.668 (3), p.414-418
Hauptverfasser:	Obara, Kazuo, Ukai, Kiyotaka, Ishikawa, Tomohisa
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences calcium Catechin - analogs & derivatives Catechin - pharmacology Contractile potentiation coronary vessels Coronary Vessels - drug effects Coronary Vessels - metabolism Coronary Vessels - physiology CPI-17 cytosol Dose-Response Relationship, Drug Drug Synergism Epigallocatechin flavanols green tea In Vitro Techniques Medical sciences Muscle Proteins - metabolism myosin light chains Myosin Light Chains - metabolism pharmacology Pharmacology. Drug treatments phosphorylation Phosphorylation - drug effects Pig coronary artery plasma membrane Potassium - pharmacology protein kinase C Protein Kinase C-delta - antagonists & inhibitors Protein Kinase C-delta - metabolism Protein kinase Cδ Protein Kinase Inhibitors - pharmacology protein transport Swine Tea - chemistry Tea catechin Vasoconstriction - drug effects
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