Structural investigation of chitosan-based microspheres with some anti-inflammatory drugs
► Chitosan hydrogels carrying some anti-inflammatory drugs were prepared. ► Their structural characterization was performed by spectroscopic techniques. ► Antioxidant activity for the supramolecular cross-linked assemblies was determined. ► Drug molecules are forming temporary chelates in chitosan h...
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| Veröffentlicht in: | Journal of molecular structure 2011, Vol.997 (1), p.78-86 |
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| creator | Dreve, Simina Kacso, Iren Popa, Adriana Raita, Oana Dragan, Felicia Bende, A. Borodi, Gh Bratu, I. |
| description | ► Chitosan hydrogels carrying some anti-inflammatory drugs were prepared. ► Their structural characterization was performed by spectroscopic techniques. ► Antioxidant activity for the supramolecular cross-linked assemblies was determined. ► Drug molecules are forming temporary chelates in chitosan hydrogels and sponges.
The use of chitosan as an excipient in oral formulations, as a drug delivery vehicle for ulcerogenic anti-inflammatory drugs and as base in polyelectrolyte complex systems, to prepare solid release systems as sponges was investigated. The preparation by double emulsification of chitosan hydrogels carrying diclofenac, acetyl-salycilic acid and hydrocortisone acetate as anti-inflammatory drugs is reported. The concentration of anti-inflammatory drug in the chitosan hydrogel generating the sponges was 0.08
mmol. Chitosan-drug loaded sponges with anti-inflammatory drugs were prepared by freeze–drying at −60
°C and 0.009
atm. Structural investigations of the solid formulations were done by Fourier-transformed infrared and ultraviolet-visible spectroscopy, spectrofluorimetry, differential scanning calorimetry and X-ray diffractometry. The results indicated that the drug molecules are forming temporary chelates in chitosan hydrogels and sponges. Electron paramagnetic resonance demonstrates the presence of free radicals in a wide range and the antioxidant activity for chitosan-drug supramolecular cross-linked assemblies. |
| doi_str_mv | 10.1016/j.molstruc.2011.05.001 |
| format | Article |
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The use of chitosan as an excipient in oral formulations, as a drug delivery vehicle for ulcerogenic anti-inflammatory drugs and as base in polyelectrolyte complex systems, to prepare solid release systems as sponges was investigated. The preparation by double emulsification of chitosan hydrogels carrying diclofenac, acetyl-salycilic acid and hydrocortisone acetate as anti-inflammatory drugs is reported. The concentration of anti-inflammatory drug in the chitosan hydrogel generating the sponges was 0.08
mmol. Chitosan-drug loaded sponges with anti-inflammatory drugs were prepared by freeze–drying at −60
°C and 0.009
atm. Structural investigations of the solid formulations were done by Fourier-transformed infrared and ultraviolet-visible spectroscopy, spectrofluorimetry, differential scanning calorimetry and X-ray diffractometry. The results indicated that the drug molecules are forming temporary chelates in chitosan hydrogels and sponges. Electron paramagnetic resonance demonstrates the presence of free radicals in a wide range and the antioxidant activity for chitosan-drug supramolecular cross-linked assemblies.</description><identifier>ISSN: 0022-2860</identifier><identifier>EISSN: 1872-8014</identifier><identifier>DOI: 10.1016/j.molstruc.2011.05.001</identifier><language>eng</language><publisher>Elsevier B.V</publisher><subject>Acetates ; anti-inflammatory agents ; Anti-inflammatory drugs ; antioxidant activity ; chelates ; Chitosan ; cortisol ; crosslinking ; differential scanning calorimetry ; Drugs ; electrolytes ; electron paramagnetic resonance spectroscopy ; emulsifying ; Formulations ; Free radicals ; hydrocolloids ; Hydrogels ; Microspheres ; Molecular spectroscopy ; Polyelectrolytes ; Sponges ; ultraviolet-visible spectroscopy ; X-radiation</subject><ispartof>Journal of molecular structure, 2011, Vol.997 (1), p.78-86</ispartof><rights>2011 Elsevier B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c368t-3b3049f13a657c227d9a2a1e942f38310aa9d527358e75880d3b6d5b15e01c683</citedby><cites>FETCH-LOGICAL-c368t-3b3049f13a657c227d9a2a1e942f38310aa9d527358e75880d3b6d5b15e01c683</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0022286011003747$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,4010,27900,27901,27902,65534</link.rule.ids></links><search><creatorcontrib>Dreve, Simina</creatorcontrib><creatorcontrib>Kacso, Iren</creatorcontrib><creatorcontrib>Popa, Adriana</creatorcontrib><creatorcontrib>Raita, Oana</creatorcontrib><creatorcontrib>Dragan, Felicia</creatorcontrib><creatorcontrib>Bende, A.</creatorcontrib><creatorcontrib>Borodi, Gh</creatorcontrib><creatorcontrib>Bratu, I.</creatorcontrib><title>Structural investigation of chitosan-based microspheres with some anti-inflammatory drugs</title><title>Journal of molecular structure</title><description>► Chitosan hydrogels carrying some anti-inflammatory drugs were prepared. ► Their structural characterization was performed by spectroscopic techniques. ► Antioxidant activity for the supramolecular cross-linked assemblies was determined. ► Drug molecules are forming temporary chelates in chitosan hydrogels and sponges.
The use of chitosan as an excipient in oral formulations, as a drug delivery vehicle for ulcerogenic anti-inflammatory drugs and as base in polyelectrolyte complex systems, to prepare solid release systems as sponges was investigated. The preparation by double emulsification of chitosan hydrogels carrying diclofenac, acetyl-salycilic acid and hydrocortisone acetate as anti-inflammatory drugs is reported. The concentration of anti-inflammatory drug in the chitosan hydrogel generating the sponges was 0.08
mmol. Chitosan-drug loaded sponges with anti-inflammatory drugs were prepared by freeze–drying at −60
°C and 0.009
atm. Structural investigations of the solid formulations were done by Fourier-transformed infrared and ultraviolet-visible spectroscopy, spectrofluorimetry, differential scanning calorimetry and X-ray diffractometry. The results indicated that the drug molecules are forming temporary chelates in chitosan hydrogels and sponges. Electron paramagnetic resonance demonstrates the presence of free radicals in a wide range and the antioxidant activity for chitosan-drug supramolecular cross-linked assemblies.</description><subject>Acetates</subject><subject>anti-inflammatory agents</subject><subject>Anti-inflammatory drugs</subject><subject>antioxidant activity</subject><subject>chelates</subject><subject>Chitosan</subject><subject>cortisol</subject><subject>crosslinking</subject><subject>differential scanning calorimetry</subject><subject>Drugs</subject><subject>electrolytes</subject><subject>electron paramagnetic resonance spectroscopy</subject><subject>emulsifying</subject><subject>Formulations</subject><subject>Free radicals</subject><subject>hydrocolloids</subject><subject>Hydrogels</subject><subject>Microspheres</subject><subject>Molecular spectroscopy</subject><subject>Polyelectrolytes</subject><subject>Sponges</subject><subject>ultraviolet-visible spectroscopy</subject><subject>X-radiation</subject><issn>0022-2860</issn><issn>1872-8014</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><recordid>eNqFkDFv2zAQhYmiBeqm_Quttk5SjqRJUVuCoGkDBMiQZOhEnKmTTUMSHZJKkH9fGk7nTLd87x3ex9h3Dg0Hrs_3zRTGlOPiGgGcN6AaAP6BrbhpRW2Arz-yFYAQtTAaPrMvKe2hECW8Yn_vj8G8RBwrPz9Tyn6L2Ye5CkPldj6HhHO9wUR9NXkXQzrsKFKqXnzeVSlMVOGcfe3nYcRpwhzia9XHZZu-sk8Djom-vd0z9nj96-HqT3179_vm6vK2dlKbXMuNhHU3cIlatU6Itu9QIKduLQZpJAfErleilcpQq4yBXm50rzZcEXCnjTxjP0-9hxieljLATj45GkecKSzJmk6LUrOWhdQn8jgjRRrsIfoJ46vlYI8q7d7-V2mPKi0oW0SV4I9TcMBgcRt9so_3BVBFo-6E6ApxcSKoLH32FG1ynmZHvY_ksu2Df-_JPzyPiwc</recordid><startdate>2011</startdate><enddate>2011</enddate><creator>Dreve, Simina</creator><creator>Kacso, Iren</creator><creator>Popa, Adriana</creator><creator>Raita, Oana</creator><creator>Dragan, Felicia</creator><creator>Bende, A.</creator><creator>Borodi, Gh</creator><creator>Bratu, I.</creator><general>Elsevier B.V</general><scope>FBQ</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U5</scope><scope>8FD</scope><scope>L7M</scope></search><sort><creationdate>2011</creationdate><title>Structural investigation of chitosan-based microspheres with some anti-inflammatory drugs</title><author>Dreve, Simina ; Kacso, Iren ; Popa, Adriana ; Raita, Oana ; Dragan, Felicia ; Bende, A. ; Borodi, Gh ; Bratu, I.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c368t-3b3049f13a657c227d9a2a1e942f38310aa9d527358e75880d3b6d5b15e01c683</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Acetates</topic><topic>anti-inflammatory agents</topic><topic>Anti-inflammatory drugs</topic><topic>antioxidant activity</topic><topic>chelates</topic><topic>Chitosan</topic><topic>cortisol</topic><topic>crosslinking</topic><topic>differential scanning calorimetry</topic><topic>Drugs</topic><topic>electrolytes</topic><topic>electron paramagnetic resonance spectroscopy</topic><topic>emulsifying</topic><topic>Formulations</topic><topic>Free radicals</topic><topic>hydrocolloids</topic><topic>Hydrogels</topic><topic>Microspheres</topic><topic>Molecular spectroscopy</topic><topic>Polyelectrolytes</topic><topic>Sponges</topic><topic>ultraviolet-visible spectroscopy</topic><topic>X-radiation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dreve, Simina</creatorcontrib><creatorcontrib>Kacso, Iren</creatorcontrib><creatorcontrib>Popa, Adriana</creatorcontrib><creatorcontrib>Raita, Oana</creatorcontrib><creatorcontrib>Dragan, Felicia</creatorcontrib><creatorcontrib>Bende, A.</creatorcontrib><creatorcontrib>Borodi, Gh</creatorcontrib><creatorcontrib>Bratu, I.</creatorcontrib><collection>AGRIS</collection><collection>CrossRef</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Technology Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><jtitle>Journal of molecular structure</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dreve, Simina</au><au>Kacso, Iren</au><au>Popa, Adriana</au><au>Raita, Oana</au><au>Dragan, Felicia</au><au>Bende, A.</au><au>Borodi, Gh</au><au>Bratu, I.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Structural investigation of chitosan-based microspheres with some anti-inflammatory drugs</atitle><jtitle>Journal of molecular structure</jtitle><date>2011</date><risdate>2011</risdate><volume>997</volume><issue>1</issue><spage>78</spage><epage>86</epage><pages>78-86</pages><issn>0022-2860</issn><eissn>1872-8014</eissn><abstract>► Chitosan hydrogels carrying some anti-inflammatory drugs were prepared. ► Their structural characterization was performed by spectroscopic techniques. ► Antioxidant activity for the supramolecular cross-linked assemblies was determined. ► Drug molecules are forming temporary chelates in chitosan hydrogels and sponges.
The use of chitosan as an excipient in oral formulations, as a drug delivery vehicle for ulcerogenic anti-inflammatory drugs and as base in polyelectrolyte complex systems, to prepare solid release systems as sponges was investigated. The preparation by double emulsification of chitosan hydrogels carrying diclofenac, acetyl-salycilic acid and hydrocortisone acetate as anti-inflammatory drugs is reported. The concentration of anti-inflammatory drug in the chitosan hydrogel generating the sponges was 0.08
mmol. Chitosan-drug loaded sponges with anti-inflammatory drugs were prepared by freeze–drying at −60
°C and 0.009
atm. Structural investigations of the solid formulations were done by Fourier-transformed infrared and ultraviolet-visible spectroscopy, spectrofluorimetry, differential scanning calorimetry and X-ray diffractometry. The results indicated that the drug molecules are forming temporary chelates in chitosan hydrogels and sponges. Electron paramagnetic resonance demonstrates the presence of free radicals in a wide range and the antioxidant activity for chitosan-drug supramolecular cross-linked assemblies.</abstract><pub>Elsevier B.V</pub><doi>10.1016/j.molstruc.2011.05.001</doi><tpages>9</tpages></addata></record> |
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| subjects | Acetates anti-inflammatory agents Anti-inflammatory drugs antioxidant activity chelates Chitosan cortisol crosslinking differential scanning calorimetry Drugs electrolytes electron paramagnetic resonance spectroscopy emulsifying Formulations Free radicals hydrocolloids Hydrogels Microspheres Molecular spectroscopy Polyelectrolytes Sponges ultraviolet-visible spectroscopy X-radiation |
| title | Structural investigation of chitosan-based microspheres with some anti-inflammatory drugs |
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