ADAMTS-1: A new human ovulatory gene and a cumulus marker for fertilization capacity
ADAM-metallopeptidase with thrombospondin type 1 motifs-1 (ADAMTS-1) null female mice show impaired follicular development and ovulatory processes. However, ADAMTS-1 expression and function in human normal ovulation and folliculogenesis have not yet been determined. The objective of this study is to...
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| Veröffentlicht in: | Molecular and cellular endocrinology 2010-10, Vol.328 (1), p.104-108 |
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| creator | Yung, Yuval Maman, Ettie Konopnicki, Sarah Cohen, Berta Brengauz, Masha Lojkin, Irina Dal Canto, Mariabeatrice Fadini, Rubens Dor, Jehoshua Hourvitz, Ariel |
| description | ADAM-metallopeptidase with thrombospondin type 1 motifs-1 (ADAMTS-1) null female mice show impaired follicular development and ovulatory processes. However, ADAMTS-1 expression and function in human normal ovulation and folliculogenesis have not yet been determined. The objective of this study is to study the expression patterns of ADAMTS-1 in human granulosa cells (GCs) obtained from follicles aspirated during
in vitro maturation (IVM) and
in vitro fertilization (IVF) procedures. We found that ADAMTS-1 expression is a luteinizing hormone/human chorionic gonadotropin (LH/hCG)-induced gene whose expression in the mural GCs directly correlated with antral follicular growth. Interestingly, we were able to show a significant correlation between ADAMTS-1 expression in cumulus cells and the fertilization capacity of the related oocyte. In conclusion, human ADAMTS-1 is an ovulatory gene and its expression is LH/hCG- and follicle-size dependent. The correlation between its expression in cumulus GCs and oocyte fertilization capacity suggests a role for ADAMTS-1 in human cumulus function. |
| doi_str_mv | 10.1016/j.mce.2010.07.019 |
| format | Article |
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in vitro maturation (IVM) and
in vitro fertilization (IVF) procedures. We found that ADAMTS-1 expression is a luteinizing hormone/human chorionic gonadotropin (LH/hCG)-induced gene whose expression in the mural GCs directly correlated with antral follicular growth. Interestingly, we were able to show a significant correlation between ADAMTS-1 expression in cumulus cells and the fertilization capacity of the related oocyte. In conclusion, human ADAMTS-1 is an ovulatory gene and its expression is LH/hCG- and follicle-size dependent. The correlation between its expression in cumulus GCs and oocyte fertilization capacity suggests a role for ADAMTS-1 in human cumulus function.</description><identifier>ISSN: 0303-7207</identifier><identifier>EISSN: 1872-8057</identifier><identifier>DOI: 10.1016/j.mce.2010.07.019</identifier><identifier>PMID: 20655981</identifier><language>eng</language><publisher>Ireland: Elsevier Ireland Ltd</publisher><subject>ADAM Proteins - genetics ; ADAM Proteins - metabolism ; ADAM Proteins - physiology ; ADAMTS-1 ; ADAMTS1 Protein ; Adult ; Biomarkers - analysis ; Biomarkers - metabolism ; Cell Size - drug effects ; Chorionic Gonadotropin - pharmacology ; Chorionic Gonadotropin - therapeutic use ; Correlation ; Cumulus Cells - metabolism ; Female ; Fertility Agents, Female - pharmacology ; Fertility Agents, Female - therapeutic use ; Fertilization ; Fertilization - genetics ; Gene Expression - drug effects ; Genes ; Granulose cells ; Hormones ; Human ; Humans ; In vitro fertilization ; Infertility, Female - diagnosis ; Infertility, Female - genetics ; Infertility, Female - metabolism ; Infertility, Female - therapy ; IVF ; IVM ; LH/hCG ; Markers ; Murals ; Ovarian Follicle - drug effects ; Ovarian Follicle - growth & development ; Ovulation ; Ovulation - genetics ; Ovulation Induction - methods ; Prognosis</subject><ispartof>Molecular and cellular endocrinology, 2010-10, Vol.328 (1), p.104-108</ispartof><rights>2010 Elsevier Ireland Ltd</rights><rights>Copyright (c) 2010 Elsevier Ireland Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-feae92103914e3809242626244eecaef5d109561ef044d91d0481dfea57a11f03</citedby><cites>FETCH-LOGICAL-c417t-feae92103914e3809242626244eecaef5d109561ef044d91d0481dfea57a11f03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.mce.2010.07.019$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20655981$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yung, Yuval</creatorcontrib><creatorcontrib>Maman, Ettie</creatorcontrib><creatorcontrib>Konopnicki, Sarah</creatorcontrib><creatorcontrib>Cohen, Berta</creatorcontrib><creatorcontrib>Brengauz, Masha</creatorcontrib><creatorcontrib>Lojkin, Irina</creatorcontrib><creatorcontrib>Dal Canto, Mariabeatrice</creatorcontrib><creatorcontrib>Fadini, Rubens</creatorcontrib><creatorcontrib>Dor, Jehoshua</creatorcontrib><creatorcontrib>Hourvitz, Ariel</creatorcontrib><title>ADAMTS-1: A new human ovulatory gene and a cumulus marker for fertilization capacity</title><title>Molecular and cellular endocrinology</title><addtitle>Mol Cell Endocrinol</addtitle><description>ADAM-metallopeptidase with thrombospondin type 1 motifs-1 (ADAMTS-1) null female mice show impaired follicular development and ovulatory processes. However, ADAMTS-1 expression and function in human normal ovulation and folliculogenesis have not yet been determined. The objective of this study is to study the expression patterns of ADAMTS-1 in human granulosa cells (GCs) obtained from follicles aspirated during
in vitro maturation (IVM) and
in vitro fertilization (IVF) procedures. We found that ADAMTS-1 expression is a luteinizing hormone/human chorionic gonadotropin (LH/hCG)-induced gene whose expression in the mural GCs directly correlated with antral follicular growth. Interestingly, we were able to show a significant correlation between ADAMTS-1 expression in cumulus cells and the fertilization capacity of the related oocyte. In conclusion, human ADAMTS-1 is an ovulatory gene and its expression is LH/hCG- and follicle-size dependent. The correlation between its expression in cumulus GCs and oocyte fertilization capacity suggests a role for ADAMTS-1 in human cumulus function.</description><subject>ADAM Proteins - genetics</subject><subject>ADAM Proteins - metabolism</subject><subject>ADAM Proteins - physiology</subject><subject>ADAMTS-1</subject><subject>ADAMTS1 Protein</subject><subject>Adult</subject><subject>Biomarkers - analysis</subject><subject>Biomarkers - metabolism</subject><subject>Cell Size - drug effects</subject><subject>Chorionic Gonadotropin - pharmacology</subject><subject>Chorionic Gonadotropin - therapeutic use</subject><subject>Correlation</subject><subject>Cumulus Cells - metabolism</subject><subject>Female</subject><subject>Fertility Agents, Female - pharmacology</subject><subject>Fertility Agents, Female - therapeutic use</subject><subject>Fertilization</subject><subject>Fertilization - genetics</subject><subject>Gene Expression - drug effects</subject><subject>Genes</subject><subject>Granulose cells</subject><subject>Hormones</subject><subject>Human</subject><subject>Humans</subject><subject>In vitro fertilization</subject><subject>Infertility, Female - diagnosis</subject><subject>Infertility, Female - genetics</subject><subject>Infertility, Female - metabolism</subject><subject>Infertility, Female - therapy</subject><subject>IVF</subject><subject>IVM</subject><subject>LH/hCG</subject><subject>Markers</subject><subject>Murals</subject><subject>Ovarian Follicle - drug effects</subject><subject>Ovarian Follicle - growth & development</subject><subject>Ovulation</subject><subject>Ovulation - genetics</subject><subject>Ovulation Induction - methods</subject><subject>Prognosis</subject><issn>0303-7207</issn><issn>1872-8057</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1P3DAQhq0KVBbaH9BL5Rtcssw4dpzAaQW0RQL10O3Zcp0JeMnHYieg5dfXq6U9gizLsvS8r0bzMPYFYY6Axelq3jmaC0h_0HPA6gObYalFVoLSe2wGOeSZFqAP2GGMKwDQSpQf2YGAQqmqxBlbLi4Xt8tfGZ7xBe_pmd9Pne358DS1dhzCht9RT9z2NbfcTd3UTpF3NjxQ4M2QLoXRt_7Fjn7oubNr6_y4-cT2G9tG-vz6HrHf366WFz-ym5_fry8WN5mTqMesIUuVQMgrlJSXUAkpinSkJHKWGlUjVKpAakDKusIaZIl1SiltERvIj9jxrncdhseJ4mg6Hx21re1pmKIpq0IICUK-S2olAYTAMpEnb5JYaMzTVGqL4g51YYgxUGPWwaflbAyC2QoyK5MEma0gA9okQSnz9bV--tNR_T_xz0gCzncApcU9eQomOk-9o9oHcqOpB_9G_V_0sJ5A</recordid><startdate>20101026</startdate><enddate>20101026</enddate><creator>Yung, Yuval</creator><creator>Maman, Ettie</creator><creator>Konopnicki, Sarah</creator><creator>Cohen, Berta</creator><creator>Brengauz, Masha</creator><creator>Lojkin, Irina</creator><creator>Dal Canto, Mariabeatrice</creator><creator>Fadini, Rubens</creator><creator>Dor, Jehoshua</creator><creator>Hourvitz, Ariel</creator><general>Elsevier Ireland Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U5</scope><scope>8FD</scope><scope>L7M</scope><scope>7X8</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope></search><sort><creationdate>20101026</creationdate><title>ADAMTS-1: A new human ovulatory gene and a cumulus marker for fertilization capacity</title><author>Yung, Yuval ; Maman, Ettie ; Konopnicki, Sarah ; Cohen, Berta ; Brengauz, Masha ; Lojkin, Irina ; Dal Canto, Mariabeatrice ; Fadini, Rubens ; Dor, Jehoshua ; Hourvitz, Ariel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-feae92103914e3809242626244eecaef5d109561ef044d91d0481dfea57a11f03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>ADAM Proteins - genetics</topic><topic>ADAM Proteins - metabolism</topic><topic>ADAM Proteins - physiology</topic><topic>ADAMTS-1</topic><topic>ADAMTS1 Protein</topic><topic>Adult</topic><topic>Biomarkers - analysis</topic><topic>Biomarkers - metabolism</topic><topic>Cell Size - drug effects</topic><topic>Chorionic Gonadotropin - pharmacology</topic><topic>Chorionic Gonadotropin - therapeutic use</topic><topic>Correlation</topic><topic>Cumulus Cells - metabolism</topic><topic>Female</topic><topic>Fertility Agents, Female - pharmacology</topic><topic>Fertility Agents, Female - therapeutic use</topic><topic>Fertilization</topic><topic>Fertilization - genetics</topic><topic>Gene Expression - drug effects</topic><topic>Genes</topic><topic>Granulose cells</topic><topic>Hormones</topic><topic>Human</topic><topic>Humans</topic><topic>In vitro fertilization</topic><topic>Infertility, Female - diagnosis</topic><topic>Infertility, Female - genetics</topic><topic>Infertility, Female - metabolism</topic><topic>Infertility, Female - therapy</topic><topic>IVF</topic><topic>IVM</topic><topic>LH/hCG</topic><topic>Markers</topic><topic>Murals</topic><topic>Ovarian Follicle - drug effects</topic><topic>Ovarian Follicle - growth & development</topic><topic>Ovulation</topic><topic>Ovulation - genetics</topic><topic>Ovulation Induction - methods</topic><topic>Prognosis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yung, Yuval</creatorcontrib><creatorcontrib>Maman, Ettie</creatorcontrib><creatorcontrib>Konopnicki, Sarah</creatorcontrib><creatorcontrib>Cohen, Berta</creatorcontrib><creatorcontrib>Brengauz, Masha</creatorcontrib><creatorcontrib>Lojkin, Irina</creatorcontrib><creatorcontrib>Dal Canto, Mariabeatrice</creatorcontrib><creatorcontrib>Fadini, Rubens</creatorcontrib><creatorcontrib>Dor, Jehoshua</creatorcontrib><creatorcontrib>Hourvitz, Ariel</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Technology Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>MEDLINE - Academic</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><jtitle>Molecular and cellular endocrinology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yung, Yuval</au><au>Maman, Ettie</au><au>Konopnicki, Sarah</au><au>Cohen, Berta</au><au>Brengauz, Masha</au><au>Lojkin, Irina</au><au>Dal Canto, Mariabeatrice</au><au>Fadini, Rubens</au><au>Dor, Jehoshua</au><au>Hourvitz, Ariel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>ADAMTS-1: A new human ovulatory gene and a cumulus marker for fertilization capacity</atitle><jtitle>Molecular and cellular endocrinology</jtitle><addtitle>Mol Cell Endocrinol</addtitle><date>2010-10-26</date><risdate>2010</risdate><volume>328</volume><issue>1</issue><spage>104</spage><epage>108</epage><pages>104-108</pages><issn>0303-7207</issn><eissn>1872-8057</eissn><abstract>ADAM-metallopeptidase with thrombospondin type 1 motifs-1 (ADAMTS-1) null female mice show impaired follicular development and ovulatory processes. However, ADAMTS-1 expression and function in human normal ovulation and folliculogenesis have not yet been determined. The objective of this study is to study the expression patterns of ADAMTS-1 in human granulosa cells (GCs) obtained from follicles aspirated during
in vitro maturation (IVM) and
in vitro fertilization (IVF) procedures. We found that ADAMTS-1 expression is a luteinizing hormone/human chorionic gonadotropin (LH/hCG)-induced gene whose expression in the mural GCs directly correlated with antral follicular growth. Interestingly, we were able to show a significant correlation between ADAMTS-1 expression in cumulus cells and the fertilization capacity of the related oocyte. In conclusion, human ADAMTS-1 is an ovulatory gene and its expression is LH/hCG- and follicle-size dependent. The correlation between its expression in cumulus GCs and oocyte fertilization capacity suggests a role for ADAMTS-1 in human cumulus function.</abstract><cop>Ireland</cop><pub>Elsevier Ireland Ltd</pub><pmid>20655981</pmid><doi>10.1016/j.mce.2010.07.019</doi><tpages>5</tpages></addata></record> |
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| subjects | ADAM Proteins - genetics ADAM Proteins - metabolism ADAM Proteins - physiology ADAMTS-1 ADAMTS1 Protein Adult Biomarkers - analysis Biomarkers - metabolism Cell Size - drug effects Chorionic Gonadotropin - pharmacology Chorionic Gonadotropin - therapeutic use Correlation Cumulus Cells - metabolism Female Fertility Agents, Female - pharmacology Fertility Agents, Female - therapeutic use Fertilization Fertilization - genetics Gene Expression - drug effects Genes Granulose cells Hormones Human Humans In vitro fertilization Infertility, Female - diagnosis Infertility, Female - genetics Infertility, Female - metabolism Infertility, Female - therapy IVF IVM LH/hCG Markers Murals Ovarian Follicle - drug effects Ovarian Follicle - growth & development Ovulation Ovulation - genetics Ovulation Induction - methods Prognosis |
| title | ADAMTS-1: A new human ovulatory gene and a cumulus marker for fertilization capacity |
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