Bax is necessary for PGC1α pro-apoptotic effect in colorectal cancer cells

We have recently shown that the transcriptional coactivator PGC1α, a master regulator of mitochondrial biogenesis and function, is involved in the control of the intestinal epithelium cell fate. Furthermore, PGC1α protects against colon cancer formation by promoting ROS accumulation and, consequentl...

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Veröffentlicht in:	Cell cycle (Georgetown, Tex.) Tex.), 2011-09, Vol.10 (17), p.2937-2945
Hauptverfasser:	D'Errico, Ilenia, Lo Sasso, Giuseppe, Salvatore, Lorena, Murzilli, Stefania, Martelli, Nicola, Cristofaro, Maricarmen, Latorre, Dominga, Villani, Gaetano, Moschetta, Antonio
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae - genetics Adenoviridae - metabolism Animals Apoptosis bcl-2-Associated X Protein - metabolism Binding Biology Bioscience Calcium Cancer Cell Colonic Neoplasms - metabolism Colonic Neoplasms - pathology Cycle DNA, Mitochondrial - analysis HCT116 Cells Heat-Shock Proteins - metabolism Humans Landes Mice Mice, Nude Mitochondria - genetics Mitochondria - metabolism Organogenesis Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha PPAR gamma - metabolism Proteins Reactive Oxygen Species - metabolism Respiratory Burst Transcription Factors - metabolism Xenograft Model Antitumor Assays
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