A high-throughput microchip-based glycan screening assay for antibody cell culture samples

A high‐throughput screening assay was developed to quantify major glycan species in the crude mammalian cell culture samples for monoclonal antibodies (mAbs). This method utilizes high‐speed microchip electrophoresis separation following a fast sample preparation procedure. Using a 96‐well ultra‐fil...

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Veröffentlicht in:	Electrophoresis 2011-05, Vol.32 (10), p.1129-1132
Hauptverfasser:	Primack, Jeremy, Flynn, Gregory C., Pan, Hai
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies Antibodies, Monoclonal - chemistry Antibodies, Monoclonal - isolation & purification Assaying Cell culture Cell Culture Techniques CHO Cells Cricetinae Cricetulus Culture Electrophoresis Electrophoresis, Microchip - methods Glycan Glycan analysis High speed High-throughput analysis High-Throughput Screening Assays - methods Humans Immunoglobulin G - chemistry Immunoglobulin G - isolation & purification Microchip Monoclonal antibody Polysaccharides - analysis Polysaccharides - chemistry Screening Separation
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