Neuromedin B receptor antagonist suppresses tumor angiogenesis and tumor growth in vitro and in vivo
Highlights ► Neuromedin B (NMB) receptor antagonist PD168368 inhibits NMB-induced endothelial angiogenesis in vitro and in vivo . ► PD168368 reduces viability and xenograft tumor growth of human MDA-MB-231 breast cancer cells. ► PD168368 induces cell cycle arrest and apoptosis in MDA-MB-231 cells. ►...
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| Veröffentlicht in: | Cancer letters 2011-12, Vol.312 (1), p.117-127 |
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| container_end_page | 127 |
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| container_issue | 1 |
| container_start_page | 117 |
| container_title | Cancer letters |
| container_volume | 312 |
| creator | Park, Hyun-Joo Kim, Su-Ryun Kim, Mi-Kyoung Choi, Kyu-Sil Jang, Hye-Ock Yun, Il Bae, Soo-Kyung Bae, Moon-Kyoung |
| description | Highlights ► Neuromedin B (NMB) receptor antagonist PD168368 inhibits NMB-induced endothelial angiogenesis in vitro and in vivo . ► PD168368 reduces viability and xenograft tumor growth of human MDA-MB-231 breast cancer cells. ► PD168368 induces cell cycle arrest and apoptosis in MDA-MB-231 cells. ► PD168368 exerts antitumor activity through the inhibition of tumor growth and angiogenesis. |
| doi_str_mv | 10.1016/j.canlet.2011.08.014 |
| format | Article |
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All rights reserved.</rights><rights>Copyright Elsevier Limited Dec 15, 2011</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c510t-75d30674b79c4b60dbcd3c81e721b676e7b96bb3d1f965719dc35c8e830e99703</citedby><cites>FETCH-LOGICAL-c510t-75d30674b79c4b60dbcd3c81e721b676e7b96bb3d1f965719dc35c8e830e99703</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0304383511005015$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21908103$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Park, Hyun-Joo</creatorcontrib><creatorcontrib>Kim, Su-Ryun</creatorcontrib><creatorcontrib>Kim, Mi-Kyoung</creatorcontrib><creatorcontrib>Choi, Kyu-Sil</creatorcontrib><creatorcontrib>Jang, Hye-Ock</creatorcontrib><creatorcontrib>Yun, Il</creatorcontrib><creatorcontrib>Bae, Soo-Kyung</creatorcontrib><creatorcontrib>Bae, Moon-Kyoung</creatorcontrib><title>Neuromedin B receptor antagonist suppresses tumor angiogenesis and tumor growth in vitro and in vivo</title><title>Cancer letters</title><addtitle>Cancer Lett</addtitle><description>Highlights ► Neuromedin B (NMB) receptor antagonist PD168368 inhibits NMB-induced endothelial angiogenesis in vitro and in vivo . ► PD168368 reduces viability and xenograft tumor growth of human MDA-MB-231 breast cancer cells. ► PD168368 induces cell cycle arrest and apoptosis in MDA-MB-231 cells. ► PD168368 exerts antitumor activity through the inhibition of tumor growth and angiogenesis.</description><subject>Angiogenesis</subject><subject>Animals</subject><subject>Breast cancer</subject><subject>Breast cancer cells</subject><subject>Breast Neoplasms - blood supply</subject><subject>Breast Neoplasms - drug therapy</subject><subject>Breast Neoplasms - pathology</subject><subject>Cell cycle</subject><subject>Cell growth</subject><subject>Cell Growth Processes - drug effects</subject><subject>Female</subject><subject>Hematology, Oncology and Palliative Medicine</subject><subject>Humans</subject><subject>Indoles - pharmacology</subject><subject>Kinases</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Mice, Nude</subject><subject>Neovascularization, Pathologic - drug therapy</subject><subject>Neovascularization, Pathologic - pathology</subject><subject>Neuromedin B receptor antagonist</subject><subject>Pyridines - pharmacology</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Receptors, Bombesin - antagonists & inhibitors</subject><subject>Receptors, Bombesin - metabolism</subject><subject>Tumor growth</subject><subject>Vascular endothelial cells</subject><subject>Xenograft Model Antitumor Assays</subject><issn>0304-3835</issn><issn>1872-7980</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUsuO1DAQtBCInV34A4QiceCU0B3Hj1yQYMUC0goOwNlKnJ7BQyYOtjNo_x7PA5D2wslqd3W1XVWMPUOoEFC-2la2m0ZKVQ2IFegKsHnAVqhVXapWw0O2Ag5NyTUXF-wyxi0AiEaJx-yixhY0Al-x4RMtwe9ocFPxtghkaU4-FN2Uuo2fXExFXOY5UIwUi7Tsjr2N8xuaKLqYi-F8vQn-V_peZJ69S8EfO8di75-wR-tujPT0fF6xbzfvvl5_KG8_v_94_ea2tAIhlUoMHKRqetXappcw9HbgViOpGnupJKm-lX3PB1y3UihsB8uF1aQ5UNsq4Ffs5Yl3Dv7nQjGZnYuWxrGbyC_R6FbWoIXkGfniHnLrlzDlxxkUIEHJppEZ1ZxQNvgYA63NHNyuC3cGwRxMMFtzMsEcTDCgTTYhjz0_ky99Vvbv0B_VM-D1CUBZjL2jYKJ1NNnsQnYgmcG7_224T2BHNznbjT_ojuK_v5hYGzBfDkE45AAxRwBQ8N8e_K8V</recordid><startdate>20111215</startdate><enddate>20111215</enddate><creator>Park, Hyun-Joo</creator><creator>Kim, Su-Ryun</creator><creator>Kim, Mi-Kyoung</creator><creator>Choi, Kyu-Sil</creator><creator>Jang, Hye-Ock</creator><creator>Yun, Il</creator><creator>Bae, Soo-Kyung</creator><creator>Bae, Moon-Kyoung</creator><general>Elsevier Ireland Ltd</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TO</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20111215</creationdate><title>Neuromedin B receptor antagonist suppresses tumor angiogenesis and tumor growth in vitro and in vivo</title><author>Park, Hyun-Joo ; Kim, Su-Ryun ; Kim, Mi-Kyoung ; Choi, Kyu-Sil ; Jang, Hye-Ock ; Yun, Il ; Bae, Soo-Kyung ; Bae, Moon-Kyoung</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c510t-75d30674b79c4b60dbcd3c81e721b676e7b96bb3d1f965719dc35c8e830e99703</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Angiogenesis</topic><topic>Animals</topic><topic>Breast cancer</topic><topic>Breast cancer cells</topic><topic>Breast Neoplasms - blood supply</topic><topic>Breast Neoplasms - drug therapy</topic><topic>Breast Neoplasms - pathology</topic><topic>Cell cycle</topic><topic>Cell growth</topic><topic>Cell Growth Processes - drug effects</topic><topic>Female</topic><topic>Hematology, Oncology and Palliative Medicine</topic><topic>Humans</topic><topic>Indoles - pharmacology</topic><topic>Kinases</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Mice, Nude</topic><topic>Neovascularization, Pathologic - drug therapy</topic><topic>Neovascularization, Pathologic - pathology</topic><topic>Neuromedin B receptor antagonist</topic><topic>Pyridines - pharmacology</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Receptors, Bombesin - antagonists & inhibitors</topic><topic>Receptors, Bombesin - metabolism</topic><topic>Tumor growth</topic><topic>Vascular endothelial cells</topic><topic>Xenograft Model Antitumor Assays</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Park, Hyun-Joo</creatorcontrib><creatorcontrib>Kim, Su-Ryun</creatorcontrib><creatorcontrib>Kim, Mi-Kyoung</creatorcontrib><creatorcontrib>Choi, Kyu-Sil</creatorcontrib><creatorcontrib>Jang, Hye-Ock</creatorcontrib><creatorcontrib>Yun, Il</creatorcontrib><creatorcontrib>Bae, Soo-Kyung</creatorcontrib><creatorcontrib>Bae, Moon-Kyoung</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Park, Hyun-Joo</au><au>Kim, Su-Ryun</au><au>Kim, Mi-Kyoung</au><au>Choi, Kyu-Sil</au><au>Jang, Hye-Ock</au><au>Yun, Il</au><au>Bae, Soo-Kyung</au><au>Bae, Moon-Kyoung</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Neuromedin B receptor antagonist suppresses tumor angiogenesis and tumor growth in vitro and in vivo</atitle><jtitle>Cancer letters</jtitle><addtitle>Cancer Lett</addtitle><date>2011-12-15</date><risdate>2011</risdate><volume>312</volume><issue>1</issue><spage>117</spage><epage>127</epage><pages>117-127</pages><issn>0304-3835</issn><eissn>1872-7980</eissn><abstract>Highlights ► Neuromedin B (NMB) receptor antagonist PD168368 inhibits NMB-induced endothelial angiogenesis in vitro and in vivo . ► PD168368 reduces viability and xenograft tumor growth of human MDA-MB-231 breast cancer cells. ► PD168368 induces cell cycle arrest and apoptosis in MDA-MB-231 cells. ► PD168368 exerts antitumor activity through the inhibition of tumor growth and angiogenesis.</abstract><cop>Ireland</cop><pub>Elsevier Ireland Ltd</pub><pmid>21908103</pmid><doi>10.1016/j.canlet.2011.08.014</doi><tpages>11</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Cancer letters, 2011-12, Vol.312 (1), p.117-127 |
| issn | 0304-3835 1872-7980 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Angiogenesis Animals Breast cancer Breast cancer cells Breast Neoplasms - blood supply Breast Neoplasms - drug therapy Breast Neoplasms - pathology Cell cycle Cell growth Cell Growth Processes - drug effects Female Hematology, Oncology and Palliative Medicine Humans Indoles - pharmacology Kinases Male Mice Mice, Inbred C57BL Mice, Nude Neovascularization, Pathologic - drug therapy Neovascularization, Pathologic - pathology Neuromedin B receptor antagonist Pyridines - pharmacology Rats Rats, Sprague-Dawley Receptors, Bombesin - antagonists & inhibitors Receptors, Bombesin - metabolism Tumor growth Vascular endothelial cells Xenograft Model Antitumor Assays |
| title | Neuromedin B receptor antagonist suppresses tumor angiogenesis and tumor growth in vitro and in vivo |
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