Weight loss induced by 6-month lifestyle intervention improves early endothelial activation and fibrinolysis in obese adolescents
Background Adolescent obesity is associated with an increased risk of adult obesity and subsequent cardiovascular diseases. The present study aimed to assess the effect of weight loss after 6‐month lifestyle intervention in obese adolescents on biomarkers of endothelial activation and fibrinolytic...
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| Veröffentlicht in: | Child : care, health & development health & development, 2011-05, Vol.37 (3), p.377-384 |
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| creator | Huang, F. del-Río-Navarro, B. E. de Castro, G. T. M. Alcántara, S. T. Sienra Monge, J. J. L. Ontiveros, J. A. P. Olivos, E. N. Barron, M. F. Lopéz, A. R. Villafaña, S. Hong, E. |
| description | Background Adolescent obesity is associated with an increased risk of adult obesity and subsequent cardiovascular diseases. The present study aimed to assess the effect of weight loss after 6‐month lifestyle intervention in obese adolescents on biomarkers of endothelial activation and fibrinolytic system.
Methods Eighty‐five obese adolescents aged 10 to 16 years were assigned to a 6‐month lifestyle intervention and 61 completed the programme. We examined the effect of the intervention on adhesion molecules (selectin E, soluble intercellular adhesion molecule 1 and soluble vascular adhesion molecule 1) and fibrinolytic parameters [plasminogen activator inhibitor‐1 (PAI‐1) and fibrinogen]. Thirty‐six lean adolescents were studied only at baseline as a comparison group.
Results Compared with lean participants, obese adolescents at baseline demonstrated significantly higher levels of triglycerides, glucose, insulin, homeostasis model assessment, soluble intercellular adhesion molecule 1, PAI‐1 and fibrinogen. After 6‐month lifestyle intervention, those obese adolescents with decreased standard deviation score‐body mass index (SDS‐BMI) displayed significant decreases in insulin (19.2 ± 11.2 vs. 26.8 ± 13.2 mU/L, P≤ 0.01), homeostasis model assessment (4.24 ± 3.19 vs. 6.58 ± 4.08, P≤ 0.01), selectin E (100.2 ± 60.9 vs. 116.0 ± 69.0 ng/mL, P≤ 0.01) and PAI‐1 (39.6 ± 38.0 vs. 51.8 ± 25.6 ng/mL, P≤ 0.05) with respect to the baseline levels. No changes in these parameters were observed in the obese adolescents with stable or increased SDS‐BMI. The changes of triglycerides after intervention in subgroup with decreased SDS‐BMI were significantly greater than those in subgroup with stable SDS‐BMI.
Conclusions The present study demonstrated increased endothelial activation and impairment of the fibrinolytic system in early life, which is in part reversible by a 6‐month lifestyle intervention. |
| doi_str_mv | 10.1111/j.1365-2214.2010.01173.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_896191238</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2365154251</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5313-f3718ae84d16c050a610912781c20befe2e71dc950f0a1a59c4ff0debac047863</originalsourceid><addsrcrecordid>eNqNkUFv1DAQhS0EokvhLyCLC6dsPXHiOAcOaAVdSgGpAvVoOc6E9eKNi50smyP_HKdb9sCJudjyfO957EcIBbaEVBfbJXBRZnkOxTJn6ZQBVHx5eEQWp8ZjsmCclRlIkZ-RZzFuWSpRsKfkLAeoZVWVC_L7Fu33zUCdj5Havh0NtrSZqMh2vh821NkO4zA5TM0Bwx77wfqe2t1d8HuMFHVwE8W-9cMGndWOajPYvb6ndN_SzjbB9t5N0c4XUN9gRKpb7zCa5BafkyeddhFfPKzn5Nv7d19X6-z6y-WH1dvrzJQceNbxCqRGWbQgDCuZFsBqyCsJJmcNdphjBa2pS9YxDbqsTdF1rMVGG1ZUUvBz8vromyb_OaZHqZ1NEzine_RjVLIWkAy5TOSrf8itH0OfhlNS1DWIsuAJkkfIhPR1ATt1F-xOh0kBU3NIaqvmLNSchZpDUvchqUOSvnzwH5sdtifh31QS8OYI_LIOp_82VqvVet4lfXbU2zjg4aTX4YcSFa9Kdfv5UtVsffMRPt2oK_4HchmxVg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>869916543</pqid></control><display><type>article</type><title>Weight loss induced by 6-month lifestyle intervention improves early endothelial activation and fibrinolysis in obese adolescents</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><source>Applied Social Sciences Index & Abstracts (ASSIA)</source><source>Education Source</source><creator>Huang, F. ; del-Río-Navarro, B. E. ; de Castro, G. T. M. ; Alcántara, S. T. ; Sienra Monge, J. J. L. ; Ontiveros, J. A. P. ; Olivos, E. N. ; Barron, M. F. ; Lopéz, A. R. ; Villafaña, S. ; Hong, E.</creator><creatorcontrib>Huang, F. ; del-Río-Navarro, B. E. ; de Castro, G. T. M. ; Alcántara, S. T. ; Sienra Monge, J. J. L. ; Ontiveros, J. A. P. ; Olivos, E. N. ; Barron, M. F. ; Lopéz, A. R. ; Villafaña, S. ; Hong, E.</creatorcontrib><description>Background Adolescent obesity is associated with an increased risk of adult obesity and subsequent cardiovascular diseases. The present study aimed to assess the effect of weight loss after 6‐month lifestyle intervention in obese adolescents on biomarkers of endothelial activation and fibrinolytic system.
Methods Eighty‐five obese adolescents aged 10 to 16 years were assigned to a 6‐month lifestyle intervention and 61 completed the programme. We examined the effect of the intervention on adhesion molecules (selectin E, soluble intercellular adhesion molecule 1 and soluble vascular adhesion molecule 1) and fibrinolytic parameters [plasminogen activator inhibitor‐1 (PAI‐1) and fibrinogen]. Thirty‐six lean adolescents were studied only at baseline as a comparison group.
Results Compared with lean participants, obese adolescents at baseline demonstrated significantly higher levels of triglycerides, glucose, insulin, homeostasis model assessment, soluble intercellular adhesion molecule 1, PAI‐1 and fibrinogen. After 6‐month lifestyle intervention, those obese adolescents with decreased standard deviation score‐body mass index (SDS‐BMI) displayed significant decreases in insulin (19.2 ± 11.2 vs. 26.8 ± 13.2 mU/L, P≤ 0.01), homeostasis model assessment (4.24 ± 3.19 vs. 6.58 ± 4.08, P≤ 0.01), selectin E (100.2 ± 60.9 vs. 116.0 ± 69.0 ng/mL, P≤ 0.01) and PAI‐1 (39.6 ± 38.0 vs. 51.8 ± 25.6 ng/mL, P≤ 0.05) with respect to the baseline levels. No changes in these parameters were observed in the obese adolescents with stable or increased SDS‐BMI. The changes of triglycerides after intervention in subgroup with decreased SDS‐BMI were significantly greater than those in subgroup with stable SDS‐BMI.
Conclusions The present study demonstrated increased endothelial activation and impairment of the fibrinolytic system in early life, which is in part reversible by a 6‐month lifestyle intervention.</description><identifier>ISSN: 0305-1862</identifier><identifier>EISSN: 1365-2214</identifier><identifier>DOI: 10.1111/j.1365-2214.2010.01173.x</identifier><identifier>PMID: 21198775</identifier><identifier>CODEN: CCHDDH</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adolescent ; Adolescents ; Amine Oxidase (Copper-Containing) - blood ; Atherosclerosis - blood ; Atherosclerosis - prevention & control ; Biomarkers ; Biomarkers - blood ; Body Composition ; Cardiovascular disease ; Case-Control Studies ; Cell Adhesion Molecules - blood ; Child ; Diet, Reducing ; E-Selectin - blood ; Exercise - physiology ; Female ; Fibrinogen ; Fibrinolysis - physiology ; Homeostasis ; Humans ; intercellular adhesion molecule 1 ; Intervention ; Life Style ; Lifestyle ; Lifestyles ; Male ; Molecules ; Obesity ; Obesity - blood ; Obesity - therapy ; Parameters ; Plasminogen Activator Inhibitor 1 - blood ; plasminogen activator inhibitor-1 ; Risk assessment ; Scientific Concepts ; selectin E ; Teenagers ; vascular adhesion molecule 1 ; Weight Loss - physiology</subject><ispartof>Child : care, health & development, 2011-05, Vol.37 (3), p.377-384</ispartof><rights>2010 Blackwell Publishing Ltd</rights><rights>2010 Blackwell Publishing Ltd.</rights><rights>Copyright Blackwell Publishing Ltd. May 2011</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5313-f3718ae84d16c050a610912781c20befe2e71dc950f0a1a59c4ff0debac047863</citedby><cites>FETCH-LOGICAL-c5313-f3718ae84d16c050a610912781c20befe2e71dc950f0a1a59c4ff0debac047863</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1365-2214.2010.01173.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1365-2214.2010.01173.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,778,782,1414,27911,27912,30986,30987,45561,45562</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21198775$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Huang, F.</creatorcontrib><creatorcontrib>del-Río-Navarro, B. E.</creatorcontrib><creatorcontrib>de Castro, G. T. M.</creatorcontrib><creatorcontrib>Alcántara, S. T.</creatorcontrib><creatorcontrib>Sienra Monge, J. J. L.</creatorcontrib><creatorcontrib>Ontiveros, J. A. P.</creatorcontrib><creatorcontrib>Olivos, E. N.</creatorcontrib><creatorcontrib>Barron, M. F.</creatorcontrib><creatorcontrib>Lopéz, A. R.</creatorcontrib><creatorcontrib>Villafaña, S.</creatorcontrib><creatorcontrib>Hong, E.</creatorcontrib><title>Weight loss induced by 6-month lifestyle intervention improves early endothelial activation and fibrinolysis in obese adolescents</title><title>Child : care, health & development</title><addtitle>Child Care Health Dev</addtitle><description>Background Adolescent obesity is associated with an increased risk of adult obesity and subsequent cardiovascular diseases. The present study aimed to assess the effect of weight loss after 6‐month lifestyle intervention in obese adolescents on biomarkers of endothelial activation and fibrinolytic system.
Methods Eighty‐five obese adolescents aged 10 to 16 years were assigned to a 6‐month lifestyle intervention and 61 completed the programme. We examined the effect of the intervention on adhesion molecules (selectin E, soluble intercellular adhesion molecule 1 and soluble vascular adhesion molecule 1) and fibrinolytic parameters [plasminogen activator inhibitor‐1 (PAI‐1) and fibrinogen]. Thirty‐six lean adolescents were studied only at baseline as a comparison group.
Results Compared with lean participants, obese adolescents at baseline demonstrated significantly higher levels of triglycerides, glucose, insulin, homeostasis model assessment, soluble intercellular adhesion molecule 1, PAI‐1 and fibrinogen. After 6‐month lifestyle intervention, those obese adolescents with decreased standard deviation score‐body mass index (SDS‐BMI) displayed significant decreases in insulin (19.2 ± 11.2 vs. 26.8 ± 13.2 mU/L, P≤ 0.01), homeostasis model assessment (4.24 ± 3.19 vs. 6.58 ± 4.08, P≤ 0.01), selectin E (100.2 ± 60.9 vs. 116.0 ± 69.0 ng/mL, P≤ 0.01) and PAI‐1 (39.6 ± 38.0 vs. 51.8 ± 25.6 ng/mL, P≤ 0.05) with respect to the baseline levels. No changes in these parameters were observed in the obese adolescents with stable or increased SDS‐BMI. The changes of triglycerides after intervention in subgroup with decreased SDS‐BMI were significantly greater than those in subgroup with stable SDS‐BMI.
Conclusions The present study demonstrated increased endothelial activation and impairment of the fibrinolytic system in early life, which is in part reversible by a 6‐month lifestyle intervention.</description><subject>Adolescent</subject><subject>Adolescents</subject><subject>Amine Oxidase (Copper-Containing) - blood</subject><subject>Atherosclerosis - blood</subject><subject>Atherosclerosis - prevention & control</subject><subject>Biomarkers</subject><subject>Biomarkers - blood</subject><subject>Body Composition</subject><subject>Cardiovascular disease</subject><subject>Case-Control Studies</subject><subject>Cell Adhesion Molecules - blood</subject><subject>Child</subject><subject>Diet, Reducing</subject><subject>E-Selectin - blood</subject><subject>Exercise - physiology</subject><subject>Female</subject><subject>Fibrinogen</subject><subject>Fibrinolysis - physiology</subject><subject>Homeostasis</subject><subject>Humans</subject><subject>intercellular adhesion molecule 1</subject><subject>Intervention</subject><subject>Life Style</subject><subject>Lifestyle</subject><subject>Lifestyles</subject><subject>Male</subject><subject>Molecules</subject><subject>Obesity</subject><subject>Obesity - blood</subject><subject>Obesity - therapy</subject><subject>Parameters</subject><subject>Plasminogen Activator Inhibitor 1 - blood</subject><subject>plasminogen activator inhibitor-1</subject><subject>Risk assessment</subject><subject>Scientific Concepts</subject><subject>selectin E</subject><subject>Teenagers</subject><subject>vascular adhesion molecule 1</subject><subject>Weight Loss - physiology</subject><issn>0305-1862</issn><issn>1365-2214</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>7QJ</sourceid><recordid>eNqNkUFv1DAQhS0EokvhLyCLC6dsPXHiOAcOaAVdSgGpAvVoOc6E9eKNi50smyP_HKdb9sCJudjyfO957EcIBbaEVBfbJXBRZnkOxTJn6ZQBVHx5eEQWp8ZjsmCclRlIkZ-RZzFuWSpRsKfkLAeoZVWVC_L7Fu33zUCdj5Havh0NtrSZqMh2vh821NkO4zA5TM0Bwx77wfqe2t1d8HuMFHVwE8W-9cMGndWOajPYvb6ndN_SzjbB9t5N0c4XUN9gRKpb7zCa5BafkyeddhFfPKzn5Nv7d19X6-z6y-WH1dvrzJQceNbxCqRGWbQgDCuZFsBqyCsJJmcNdphjBa2pS9YxDbqsTdF1rMVGG1ZUUvBz8vromyb_OaZHqZ1NEzine_RjVLIWkAy5TOSrf8itH0OfhlNS1DWIsuAJkkfIhPR1ATt1F-xOh0kBU3NIaqvmLNSchZpDUvchqUOSvnzwH5sdtifh31QS8OYI_LIOp_82VqvVet4lfXbU2zjg4aTX4YcSFa9Kdfv5UtVsffMRPt2oK_4HchmxVg</recordid><startdate>201105</startdate><enddate>201105</enddate><creator>Huang, F.</creator><creator>del-Río-Navarro, B. E.</creator><creator>de Castro, G. T. M.</creator><creator>Alcántara, S. T.</creator><creator>Sienra Monge, J. J. L.</creator><creator>Ontiveros, J. A. P.</creator><creator>Olivos, E. N.</creator><creator>Barron, M. F.</creator><creator>Lopéz, A. R.</creator><creator>Villafaña, S.</creator><creator>Hong, E.</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QJ</scope></search><sort><creationdate>201105</creationdate><title>Weight loss induced by 6-month lifestyle intervention improves early endothelial activation and fibrinolysis in obese adolescents</title><author>Huang, F. ; del-Río-Navarro, B. E. ; de Castro, G. T. M. ; Alcántara, S. T. ; Sienra Monge, J. J. L. ; Ontiveros, J. A. P. ; Olivos, E. N. ; Barron, M. F. ; Lopéz, A. R. ; Villafaña, S. ; Hong, E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5313-f3718ae84d16c050a610912781c20befe2e71dc950f0a1a59c4ff0debac047863</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adolescent</topic><topic>Adolescents</topic><topic>Amine Oxidase (Copper-Containing) - blood</topic><topic>Atherosclerosis - blood</topic><topic>Atherosclerosis - prevention & control</topic><topic>Biomarkers</topic><topic>Biomarkers - blood</topic><topic>Body Composition</topic><topic>Cardiovascular disease</topic><topic>Case-Control Studies</topic><topic>Cell Adhesion Molecules - blood</topic><topic>Child</topic><topic>Diet, Reducing</topic><topic>E-Selectin - blood</topic><topic>Exercise - physiology</topic><topic>Female</topic><topic>Fibrinogen</topic><topic>Fibrinolysis - physiology</topic><topic>Homeostasis</topic><topic>Humans</topic><topic>intercellular adhesion molecule 1</topic><topic>Intervention</topic><topic>Life Style</topic><topic>Lifestyle</topic><topic>Lifestyles</topic><topic>Male</topic><topic>Molecules</topic><topic>Obesity</topic><topic>Obesity - blood</topic><topic>Obesity - therapy</topic><topic>Parameters</topic><topic>Plasminogen Activator Inhibitor 1 - blood</topic><topic>plasminogen activator inhibitor-1</topic><topic>Risk assessment</topic><topic>Scientific Concepts</topic><topic>selectin E</topic><topic>Teenagers</topic><topic>vascular adhesion molecule 1</topic><topic>Weight Loss - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Huang, F.</creatorcontrib><creatorcontrib>del-Río-Navarro, B. E.</creatorcontrib><creatorcontrib>de Castro, G. T. M.</creatorcontrib><creatorcontrib>Alcántara, S. T.</creatorcontrib><creatorcontrib>Sienra Monge, J. J. L.</creatorcontrib><creatorcontrib>Ontiveros, J. A. P.</creatorcontrib><creatorcontrib>Olivos, E. N.</creatorcontrib><creatorcontrib>Barron, M. F.</creatorcontrib><creatorcontrib>Lopéz, A. R.</creatorcontrib><creatorcontrib>Villafaña, S.</creatorcontrib><creatorcontrib>Hong, E.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Applied Social Sciences Index & Abstracts (ASSIA)</collection><jtitle>Child : care, health & development</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Huang, F.</au><au>del-Río-Navarro, B. E.</au><au>de Castro, G. T. M.</au><au>Alcántara, S. T.</au><au>Sienra Monge, J. J. L.</au><au>Ontiveros, J. A. P.</au><au>Olivos, E. N.</au><au>Barron, M. F.</au><au>Lopéz, A. R.</au><au>Villafaña, S.</au><au>Hong, E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Weight loss induced by 6-month lifestyle intervention improves early endothelial activation and fibrinolysis in obese adolescents</atitle><jtitle>Child : care, health & development</jtitle><addtitle>Child Care Health Dev</addtitle><date>2011-05</date><risdate>2011</risdate><volume>37</volume><issue>3</issue><spage>377</spage><epage>384</epage><pages>377-384</pages><issn>0305-1862</issn><eissn>1365-2214</eissn><coden>CCHDDH</coden><abstract>Background Adolescent obesity is associated with an increased risk of adult obesity and subsequent cardiovascular diseases. The present study aimed to assess the effect of weight loss after 6‐month lifestyle intervention in obese adolescents on biomarkers of endothelial activation and fibrinolytic system.
Methods Eighty‐five obese adolescents aged 10 to 16 years were assigned to a 6‐month lifestyle intervention and 61 completed the programme. We examined the effect of the intervention on adhesion molecules (selectin E, soluble intercellular adhesion molecule 1 and soluble vascular adhesion molecule 1) and fibrinolytic parameters [plasminogen activator inhibitor‐1 (PAI‐1) and fibrinogen]. Thirty‐six lean adolescents were studied only at baseline as a comparison group.
Results Compared with lean participants, obese adolescents at baseline demonstrated significantly higher levels of triglycerides, glucose, insulin, homeostasis model assessment, soluble intercellular adhesion molecule 1, PAI‐1 and fibrinogen. After 6‐month lifestyle intervention, those obese adolescents with decreased standard deviation score‐body mass index (SDS‐BMI) displayed significant decreases in insulin (19.2 ± 11.2 vs. 26.8 ± 13.2 mU/L, P≤ 0.01), homeostasis model assessment (4.24 ± 3.19 vs. 6.58 ± 4.08, P≤ 0.01), selectin E (100.2 ± 60.9 vs. 116.0 ± 69.0 ng/mL, P≤ 0.01) and PAI‐1 (39.6 ± 38.0 vs. 51.8 ± 25.6 ng/mL, P≤ 0.05) with respect to the baseline levels. No changes in these parameters were observed in the obese adolescents with stable or increased SDS‐BMI. The changes of triglycerides after intervention in subgroup with decreased SDS‐BMI were significantly greater than those in subgroup with stable SDS‐BMI.
Conclusions The present study demonstrated increased endothelial activation and impairment of the fibrinolytic system in early life, which is in part reversible by a 6‐month lifestyle intervention.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>21198775</pmid><doi>10.1111/j.1365-2214.2010.01173.x</doi><tpages>8</tpages></addata></record> |
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| subjects | Adolescent Adolescents Amine Oxidase (Copper-Containing) - blood Atherosclerosis - blood Atherosclerosis - prevention & control Biomarkers Biomarkers - blood Body Composition Cardiovascular disease Case-Control Studies Cell Adhesion Molecules - blood Child Diet, Reducing E-Selectin - blood Exercise - physiology Female Fibrinogen Fibrinolysis - physiology Homeostasis Humans intercellular adhesion molecule 1 Intervention Life Style Lifestyle Lifestyles Male Molecules Obesity Obesity - blood Obesity - therapy Parameters Plasminogen Activator Inhibitor 1 - blood plasminogen activator inhibitor-1 Risk assessment Scientific Concepts selectin E Teenagers vascular adhesion molecule 1 Weight Loss - physiology |
| title | Weight loss induced by 6-month lifestyle intervention improves early endothelial activation and fibrinolysis in obese adolescents |
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