Analysis of intracellular doxorubicin and its metabolites by ultra-high-performance liquid chromatography

Doxorubicin, a highly effective anticancer drug, produces severe side effect such as cardiotoxicity, which is mainly caused by its metabolite, doxorubicinol. While in vitro studies by measuring cellular concentration of doxorubicin have been reported, there have been no reports on measuring cellular...

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Veröffentlicht in:	Journal of chromatography. B, Analytical technologies in the biomedical and life sciences Analytical technologies in the biomedical and life sciences, 2010-06, Vol.878 (19), p.1466-1470
Hauptverfasser:	Sakai-Kato, Kumiko, Saito, Eiko, Ishikura, Keiko, Kawanishi, Toru
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Analytical, structural and metabolic biochemistry Biological and medical sciences Chromatography, High Pressure Liquid - methods Doxorubicin Doxorubicin - analogs & derivatives Doxorubicin - analysis Doxorubicin - chemistry Doxorubicinol Fundamental and applied biological sciences. Psychology General pharmacology HeLa Cells HT29 Cells Humans Intracellular Space Linear Models Medical sciences Pharmacology. Drug treatments Sensitivity and Specificity Ultra-high-performance liquid chromatography
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