POLY(D,L-LACTIDE-CO-GLYCOLIDE)/HYDROXYAPATITE CORE-SHELL NANOSPHERE. PT.2. SIMULTANEOUS RELEASE OF A DRUG AND A PRODRUG (CLINDAMYCIN AND CLINDAMYCIN PHOSPHATE)

Poly(D,L-lactide-co-glycolide)/hydroxyapatite (PLGA/HAp) core-shell nanostructures were used as the carrier of clindamycin-base, as a drug, and clindamycin-2-phosphate, as a prodrug model. As a result, a two-step release was observed: the controlled release of the more soluble phosphate form and the...

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Veröffentlicht in:	Colloids and surfaces, B, Biointerfaces B, Biointerfaces, 2011-01, Vol.82 (2), p.414-421
Hauptverfasser:	Vukomanovic, M, Skapin, S D, Poljansek, I, Zagar, E, Kralj, B, Ignjatovic, N, Uskokovic, D
Format:	Artikel
Sprache:	eng
Schlagworte:	Carriers Degradation Drugs Hydroxyapatite Nanocomposites Nanomaterials Nanostructure Phosphates
Online-Zugang:	Volltext
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