Characterization of Matrix Metalloproteinase Inhibitors: Angiogenesis and Tumor Models

Since the matrix metalloproteinases (MMPs) have an essential role in the process of tumor growth, invasion and metastasis, small molecule MMP inhibitors have the ability to modulate tumor progression in animals and the potential to be of therapeutic benefit to cancer patients. The antiangiogenic pro...

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Veröffentlicht in:	Current Protocols in Pharmacology 2001-08, Vol.13 (1), p.5.23.1-5.23.12
Hauptverfasser:	Albert, Daniel H., Davidsen, Steven K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Inhibitors - pharmacology Angiogenesis Inhibitors - therapeutic use Animals Enzyme Inhibitors - pharmacology Enzyme Inhibitors - therapeutic use Female Humans Matrix Metalloproteinase Inhibitors Matrix Metalloproteinases - metabolism Melanoma, Experimental - drug therapy Melanoma, Experimental - enzymology Mice Mice, Inbred C57BL Neovascularization, Pathologic - drug therapy Neovascularization, Pathologic - enzymology Xenograft Model Antitumor Assays - methods
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