Cap and cap-binding proteins in the control of gene expression

The 5′ mRNA cap structure is essential for efficient gene expression from yeast to human. It plays a critical role in all aspects of the life cycle of an mRNA molecule. Capping occurs co‐transcriptionally on the nascent pre‐mRNA as it emerges from the RNA exit channel of RNA polymerase II. The cap s...

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Veröffentlicht in:	Wiley interdisciplinary reviews. RNA 2011-03, Vol.2 (2), p.277-298
Hauptverfasser:	Topisirovic, Ivan, Svitkin, Yuri V., Sonenberg, Nahum, Shatkin, Aaron J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Active Transport, Cell Nucleus - genetics Active Transport, Cell Nucleus - physiology Alternative Splicing - genetics Alternative Splicing - physiology Animals Biodegradation Cell Nucleus - metabolism Cytoplasm DNA-directed RNA polymerase Gene expression Gene Expression Regulation Humans Initiation factor eIF-4E Life cycles Models, Biological Models, Molecular mRNA guanylyltransferase mRNA processing Nonsense Mediated mRNA Decay - genetics Nonsense Mediated mRNA Decay - physiology Nuclear transport Polyadenylation Proteins RNA Cap-Binding Proteins - chemistry RNA Cap-Binding Proteins - genetics RNA Cap-Binding Proteins - metabolism RNA Cap-Binding Proteins - physiology RNA Caps - chemistry RNA Caps - genetics RNA Caps - metabolism RNA Caps - physiology RNA processing RNA Processing, Post-Transcriptional Splicing Transcription
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