mTORC2 targets AGC kinases through Sin1-dependent recruitment

The protein kinase TOR (target of rapamycin) is a key regulator of cell growth and metabolism with significant clinical relevance. In mammals, TOR signals through two distinct multi-protein complexes, mTORC1 and mTORC2 (mammalian TOR complex 1 and 2 respectively), the subunits of which appear to def...

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Veröffentlicht in:	Biochemical journal 2011-10, Vol.439 (2), p.287-297
Hauptverfasser:	Cameron, Angus J M, Linch, Mark D, Saurin, Adrian T, Escribano, Cristina, Parker, Peter J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - metabolism Cell Line Humans Phosphorylation Protein Kinases - metabolism Transcription Factors - metabolism
Online-Zugang:	Volltext
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