Histologic classification of microscopic portal venous invasion to predict prognosis in hepatocellular carcinoma
Summary Portal venous invasion is one of the most important prognostic factors after surgical resection of hepatocellular carcinoma. Microscopic portal venous invasion can be evaluated histologically. We examined 280 hepatocellular carcinomas with microscopic portal venous invasion (n = 125) or with...
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| Veröffentlicht in: | Human pathology 2011-10, Vol.42 (10), p.1531-1538 |
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| creator | Fujita, Nobuhiro, MD Aishima, Shinichi, MD, PhD Iguchi, Tomohiro, MD, PhD Mano, Yohei, MD Taketomi, Akinobu, MD, PhD Shirabe, Ken, MD, PhD Honda, Hiroshi, MD, PhD Tsuneyoshi, Masazumi, MD, PhD Oda, Yoshinao, MD, PhD |
| description | Summary Portal venous invasion is one of the most important prognostic factors after surgical resection of hepatocellular carcinoma. Microscopic portal venous invasion can be evaluated histologically. We examined 280 hepatocellular carcinomas with microscopic portal venous invasion (n = 125) or without it (n = 155) for 3 characteristics: the number of invaded portal vessels, the maximum number of invading carcinoma cells, and the farthest distance from the tumor. Univariate analysis of overall and disease-free survival revealed that the number of invaded portal vessels and the number of invading carcinoma cells were poor prognostic factors. Therefore, we classified patients with microscopic portal venous invasion into 2 groups: a high–microscopic portal venous invasion group, in which there were multiple invaded portal venous vessels (≥2) and more than 50 invading carcinoma cells (n = 57), and a low–microscopic portal venous invasion group, in which microscopic portal venous invasion was observed but with invasion of only a single portal venous vessel or fewer than 50 invading carcinoma cells (n = 68). The high–microscopic portal venous invasion group showed significantly higher α -fetoprotein levels, larger tumor size, and higher frequencies of poorly differentiated histology, capsule infiltration, and intrahepatic metastasis compared with the low–microscopic portal venous invasion group ( P = .0496, P < .0001, P = .0431, P = .0180, and P = .0012, respectively). The high–microscopic portal venous invasion group showed poorer overall survival and disease-free survival rates than the low–microscopic portal venous invasion group ( P = .0004 and P = .0003), and the high–microscopic portal venous invasion group was an independent prognostic factor for disease-free survival ( P = .0259). We proposed a new definition for classifying microscopic portal venous invasion and documented the necessity of definite histologic evaluation of it. |
| doi_str_mv | 10.1016/j.humpath.2010.12.016 |
| format | Article |
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Microscopic portal venous invasion can be evaluated histologically. We examined 280 hepatocellular carcinomas with microscopic portal venous invasion (n = 125) or without it (n = 155) for 3 characteristics: the number of invaded portal vessels, the maximum number of invading carcinoma cells, and the farthest distance from the tumor. Univariate analysis of overall and disease-free survival revealed that the number of invaded portal vessels and the number of invading carcinoma cells were poor prognostic factors. Therefore, we classified patients with microscopic portal venous invasion into 2 groups: a high–microscopic portal venous invasion group, in which there were multiple invaded portal venous vessels (≥2) and more than 50 invading carcinoma cells (n = 57), and a low–microscopic portal venous invasion group, in which microscopic portal venous invasion was observed but with invasion of only a single portal venous vessel or fewer than 50 invading carcinoma cells (n = 68). The high–microscopic portal venous invasion group showed significantly higher α -fetoprotein levels, larger tumor size, and higher frequencies of poorly differentiated histology, capsule infiltration, and intrahepatic metastasis compared with the low–microscopic portal venous invasion group ( P = .0496, P < .0001, P = .0431, P = .0180, and P = .0012, respectively). The high–microscopic portal venous invasion group showed poorer overall survival and disease-free survival rates than the low–microscopic portal venous invasion group ( P = .0004 and P = .0003), and the high–microscopic portal venous invasion group was an independent prognostic factor for disease-free survival ( P = .0259). We proposed a new definition for classifying microscopic portal venous invasion and documented the necessity of definite histologic evaluation of it.</description><identifier>ISSN: 0046-8177</identifier><identifier>EISSN: 1532-8392</identifier><identifier>DOI: 10.1016/j.humpath.2010.12.016</identifier><identifier>PMID: 21496875</identifier><identifier>CODEN: HPCQA4</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Aged ; Analysis of Variance ; Biological and medical sciences ; Cancer ; Carcinoma, Hepatocellular - diagnosis ; Carcinoma, Hepatocellular - pathology ; Disease-Free Survival ; Female ; Gastroenterology. Liver. Pancreas. Abdomen ; Hepatocellular carcinoma ; Humans ; Investigative techniques, diagnostic techniques (general aspects) ; Liver cancer ; Liver Neoplasms - diagnosis ; Liver Neoplasms - pathology ; Liver. Biliary tract. Portal circulation. Exocrine pancreas ; Male ; Medical sciences ; Neoplasm Invasiveness ; Pathology ; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques ; Portal Vein - pathology ; Portal venous invasion ; Prognosis ; Studies ; Survival Rate ; Tumors ; Vascular invasion ; Veins & arteries</subject><ispartof>Human pathology, 2011-10, Vol.42 (10), p.1531-1538</ispartof><rights>Elsevier Inc.</rights><rights>2011 Elsevier Inc.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c543t-c8e94385cbd15f1d9df38f72c18af8ba5ff79206dc31330fb71bff08006bbc2b3</citedby><cites>FETCH-LOGICAL-c543t-c8e94385cbd15f1d9df38f72c18af8ba5ff79206dc31330fb71bff08006bbc2b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.humpath.2010.12.016$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27923,27924,45994</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24613037$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21496875$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fujita, Nobuhiro, MD</creatorcontrib><creatorcontrib>Aishima, Shinichi, MD, PhD</creatorcontrib><creatorcontrib>Iguchi, Tomohiro, MD, PhD</creatorcontrib><creatorcontrib>Mano, Yohei, MD</creatorcontrib><creatorcontrib>Taketomi, Akinobu, MD, PhD</creatorcontrib><creatorcontrib>Shirabe, Ken, MD, PhD</creatorcontrib><creatorcontrib>Honda, Hiroshi, MD, PhD</creatorcontrib><creatorcontrib>Tsuneyoshi, Masazumi, MD, PhD</creatorcontrib><creatorcontrib>Oda, Yoshinao, MD, PhD</creatorcontrib><title>Histologic classification of microscopic portal venous invasion to predict prognosis in hepatocellular carcinoma</title><title>Human pathology</title><addtitle>Hum Pathol</addtitle><description>Summary Portal venous invasion is one of the most important prognostic factors after surgical resection of hepatocellular carcinoma. Microscopic portal venous invasion can be evaluated histologically. We examined 280 hepatocellular carcinomas with microscopic portal venous invasion (n = 125) or without it (n = 155) for 3 characteristics: the number of invaded portal vessels, the maximum number of invading carcinoma cells, and the farthest distance from the tumor. Univariate analysis of overall and disease-free survival revealed that the number of invaded portal vessels and the number of invading carcinoma cells were poor prognostic factors. Therefore, we classified patients with microscopic portal venous invasion into 2 groups: a high–microscopic portal venous invasion group, in which there were multiple invaded portal venous vessels (≥2) and more than 50 invading carcinoma cells (n = 57), and a low–microscopic portal venous invasion group, in which microscopic portal venous invasion was observed but with invasion of only a single portal venous vessel or fewer than 50 invading carcinoma cells (n = 68). The high–microscopic portal venous invasion group showed significantly higher α -fetoprotein levels, larger tumor size, and higher frequencies of poorly differentiated histology, capsule infiltration, and intrahepatic metastasis compared with the low–microscopic portal venous invasion group ( P = .0496, P < .0001, P = .0431, P = .0180, and P = .0012, respectively). The high–microscopic portal venous invasion group showed poorer overall survival and disease-free survival rates than the low–microscopic portal venous invasion group ( P = .0004 and P = .0003), and the high–microscopic portal venous invasion group was an independent prognostic factor for disease-free survival ( P = .0259). We proposed a new definition for classifying microscopic portal venous invasion and documented the necessity of definite histologic evaluation of it.</description><subject>Aged</subject><subject>Analysis of Variance</subject><subject>Biological and medical sciences</subject><subject>Cancer</subject><subject>Carcinoma, Hepatocellular - diagnosis</subject><subject>Carcinoma, Hepatocellular - pathology</subject><subject>Disease-Free Survival</subject><subject>Female</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Hepatocellular carcinoma</subject><subject>Humans</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Liver cancer</subject><subject>Liver Neoplasms - diagnosis</subject><subject>Liver Neoplasms - pathology</subject><subject>Liver. Biliary tract. Portal circulation. Exocrine pancreas</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Neoplasm Invasiveness</subject><subject>Pathology</subject><subject>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</subject><subject>Portal Vein - pathology</subject><subject>Portal venous invasion</subject><subject>Prognosis</subject><subject>Studies</subject><subject>Survival Rate</subject><subject>Tumors</subject><subject>Vascular invasion</subject><subject>Veins & arteries</subject><issn>0046-8177</issn><issn>1532-8392</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFksFu1DAQhi0EokvhEUCREOKUrSeOE-cCQhXQSpU4FM6WM7G7Xhw72MlKfXsc7UKlXnoaaeab0T_zDyFvgW6BQnOx3-6WcVLzblvRNVdtc_YZ2QBnVSlYVz0nG0rrphTQtmfkVUp7SgF4zV-SswrqrhEt35DpyqY5uHBnsUCnUrLGoppt8EUwxWgxhoRhytUpxFm54qB9WFJh_UGllZpDMUU9WJxzDHc-JLtWi53O4gJq5xanYoEqovVhVK_JC6Nc0m9O8Zz8-vb15-VVefPj-_Xll5sSec3mEoXuaiY49gNwA0M3GCZMWyEIZUSvuDFtV9FmQAaMUdO30BtDBaVN32PVs3Py8Tg3q_qz6DTL0aZVjvI6LyBFxwXn0DWZfP-I3Icl-ixOAmW1EKKmIlP8SK0XSVEbOUU7qnifIbk6Ivfy5IhcHZFQyZzNfe9O05d-1MP_rn8WZODDCVAJlTNRebTpgasbYJS1mft85HS-2sHqKBNa7THfPmqc5RDsk1I-PZqAzvpst_ut73V62Fqm3CBv1_dZvweAUsoYZ38BEk3D1Q</recordid><startdate>20111001</startdate><enddate>20111001</enddate><creator>Fujita, Nobuhiro, MD</creator><creator>Aishima, Shinichi, MD, PhD</creator><creator>Iguchi, Tomohiro, MD, PhD</creator><creator>Mano, Yohei, MD</creator><creator>Taketomi, Akinobu, MD, PhD</creator><creator>Shirabe, Ken, MD, PhD</creator><creator>Honda, Hiroshi, MD, PhD</creator><creator>Tsuneyoshi, Masazumi, MD, PhD</creator><creator>Oda, Yoshinao, MD, PhD</creator><general>Elsevier Inc</general><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>20111001</creationdate><title>Histologic classification of microscopic portal venous invasion to predict prognosis in hepatocellular carcinoma</title><author>Fujita, Nobuhiro, MD ; Aishima, Shinichi, MD, PhD ; Iguchi, Tomohiro, MD, PhD ; Mano, Yohei, MD ; Taketomi, Akinobu, MD, PhD ; Shirabe, Ken, MD, PhD ; Honda, Hiroshi, MD, PhD ; Tsuneyoshi, Masazumi, MD, PhD ; Oda, Yoshinao, MD, PhD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c543t-c8e94385cbd15f1d9df38f72c18af8ba5ff79206dc31330fb71bff08006bbc2b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Aged</topic><topic>Analysis of Variance</topic><topic>Biological and medical sciences</topic><topic>Cancer</topic><topic>Carcinoma, Hepatocellular - diagnosis</topic><topic>Carcinoma, Hepatocellular - pathology</topic><topic>Disease-Free Survival</topic><topic>Female</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Hepatocellular carcinoma</topic><topic>Humans</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Liver cancer</topic><topic>Liver Neoplasms - diagnosis</topic><topic>Liver Neoplasms - pathology</topic><topic>Liver. Biliary tract. Portal circulation. Exocrine pancreas</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Neoplasm Invasiveness</topic><topic>Pathology</topic><topic>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</topic><topic>Portal Vein - pathology</topic><topic>Portal venous invasion</topic><topic>Prognosis</topic><topic>Studies</topic><topic>Survival Rate</topic><topic>Tumors</topic><topic>Vascular invasion</topic><topic>Veins & arteries</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fujita, Nobuhiro, MD</creatorcontrib><creatorcontrib>Aishima, Shinichi, MD, PhD</creatorcontrib><creatorcontrib>Iguchi, Tomohiro, MD, PhD</creatorcontrib><creatorcontrib>Mano, Yohei, MD</creatorcontrib><creatorcontrib>Taketomi, Akinobu, MD, PhD</creatorcontrib><creatorcontrib>Shirabe, Ken, MD, PhD</creatorcontrib><creatorcontrib>Honda, Hiroshi, MD, PhD</creatorcontrib><creatorcontrib>Tsuneyoshi, Masazumi, MD, PhD</creatorcontrib><creatorcontrib>Oda, Yoshinao, MD, PhD</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Human pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fujita, Nobuhiro, MD</au><au>Aishima, Shinichi, MD, PhD</au><au>Iguchi, Tomohiro, MD, PhD</au><au>Mano, Yohei, MD</au><au>Taketomi, Akinobu, MD, PhD</au><au>Shirabe, Ken, MD, PhD</au><au>Honda, Hiroshi, MD, PhD</au><au>Tsuneyoshi, Masazumi, MD, PhD</au><au>Oda, Yoshinao, MD, PhD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Histologic classification of microscopic portal venous invasion to predict prognosis in hepatocellular carcinoma</atitle><jtitle>Human pathology</jtitle><addtitle>Hum Pathol</addtitle><date>2011-10-01</date><risdate>2011</risdate><volume>42</volume><issue>10</issue><spage>1531</spage><epage>1538</epage><pages>1531-1538</pages><issn>0046-8177</issn><eissn>1532-8392</eissn><coden>HPCQA4</coden><abstract>Summary Portal venous invasion is one of the most important prognostic factors after surgical resection of hepatocellular carcinoma. Microscopic portal venous invasion can be evaluated histologically. We examined 280 hepatocellular carcinomas with microscopic portal venous invasion (n = 125) or without it (n = 155) for 3 characteristics: the number of invaded portal vessels, the maximum number of invading carcinoma cells, and the farthest distance from the tumor. Univariate analysis of overall and disease-free survival revealed that the number of invaded portal vessels and the number of invading carcinoma cells were poor prognostic factors. Therefore, we classified patients with microscopic portal venous invasion into 2 groups: a high–microscopic portal venous invasion group, in which there were multiple invaded portal venous vessels (≥2) and more than 50 invading carcinoma cells (n = 57), and a low–microscopic portal venous invasion group, in which microscopic portal venous invasion was observed but with invasion of only a single portal venous vessel or fewer than 50 invading carcinoma cells (n = 68). The high–microscopic portal venous invasion group showed significantly higher α -fetoprotein levels, larger tumor size, and higher frequencies of poorly differentiated histology, capsule infiltration, and intrahepatic metastasis compared with the low–microscopic portal venous invasion group ( P = .0496, P < .0001, P = .0431, P = .0180, and P = .0012, respectively). The high–microscopic portal venous invasion group showed poorer overall survival and disease-free survival rates than the low–microscopic portal venous invasion group ( P = .0004 and P = .0003), and the high–microscopic portal venous invasion group was an independent prognostic factor for disease-free survival ( P = .0259). We proposed a new definition for classifying microscopic portal venous invasion and documented the necessity of definite histologic evaluation of it.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>21496875</pmid><doi>10.1016/j.humpath.2010.12.016</doi><tpages>8</tpages></addata></record> |
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| subjects | Aged Analysis of Variance Biological and medical sciences Cancer Carcinoma, Hepatocellular - diagnosis Carcinoma, Hepatocellular - pathology Disease-Free Survival Female Gastroenterology. Liver. Pancreas. Abdomen Hepatocellular carcinoma Humans Investigative techniques, diagnostic techniques (general aspects) Liver cancer Liver Neoplasms - diagnosis Liver Neoplasms - pathology Liver. Biliary tract. Portal circulation. Exocrine pancreas Male Medical sciences Neoplasm Invasiveness Pathology Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Portal Vein - pathology Portal venous invasion Prognosis Studies Survival Rate Tumors Vascular invasion Veins & arteries |
| title | Histologic classification of microscopic portal venous invasion to predict prognosis in hepatocellular carcinoma |
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